EGAGenomicsOtherhttps://ega-archive.org/studies/EGAS00001003346EGAEGA study EGAS00001003346Peripheral blood RNA-sequencing in 4,732 participants of the INTERVAL cohortEGArestrictedwhole transcriptome, Gene Expression, Transcriptome, Expression Signature, Transcriptome Profile, Gene Expression Profiles, Transcriptome Profiles., Expression Signatures, Profile, Gene Expression Signatures, Expression Profiles, Transcriptomes, Gene Expression Profile, Gene, Gene Expression Signature, Profiles, Signature, Expression Profile, Signatureslipids, Individual Health, RNA, Ribonucleic, nuclear mRNA cis splicing, whole blood, ribose nucleic acid, FESTA-L, protein complex, FESTA-S, Blood, Traits, Proteins, ribonucleic acids, familial, secondary metabolites, Gene, Modern., RNS, Trait Loci, protein, Normalcy, protein-containing complex, Quantitative, Normalcies, Human, Quantitative Trait, protein polypeptide chains, primary metabolites, native protein, natural protein, polypeptide chain, Homo sapiens, yeast nucleic acid, Ribonukleinsaeure, PBMC, Quantitative Trait Locus, Protein, Lipid, Gene Products, pathogenesis, pentosenucleic acids, AW048865, Ribonucleic acids, Donors, Donor, Individual, protein aggregate, Non Polyadenylated, Man, Blood Donor, U19, RNA Gene Products, Normalities, average, ribonucleic acid, Acid, study, BM040, Peripheral Blood, Gene Expressions, Man (Taxonomy), Normality, Non Polyadenylated RNA, Non-Polyadenylated, metabolite, Trait Locus, proteins, Ribonucleic Acid, causes, Dietary Fiber, Expressions, Locus, TRAITS, Non-Polyadenylated RNA, Reticuloendothelial System, Protein Gene Products, genetic, Gene Proteins, Phenotypes, via U2-type spliceosome, Health, Festa, PBMCs, Loci, metabolites, Modern Man, causality, inherited genetic, Expression, Quantitative Trait Loci Genes, constitutitional genetic, hereditary, humansfalseHG Transcriptome sequencing in the INTERVAL cohortWe performed bulk RNA-sequencing on peripheral blood collected from 4,732 blood donors recruited as part of the INTERVAL study. Using these data, we mapped gene expression and splicing quantitative trait loci (QTLs). Then, we integrated these data with protein, metabolite and lipid QTLs in the same individuals. The study aimed to identify the shared genetic etiology across transcriptional phenotypes, molecular traits and health outcomes in humans.2023-12-15 14:43:53EGAS000010033469606EGAD00001008015EGAC00001000205