EGAGenomicsOtherhttps://ega-archive.org/studies/EGAS00001003365EGAEGA study EGAS00001003365Single-cell transcriptome of T-ALL P1Finding structural variation from the patient-derived xenografts of pediatric T-cell leukemia at the single-cell levelSingle-cell transcriptome of T-ALL PDX under drug treatmentrestrictedEGASIGNS SYMPTOMS, T-cell leukemia, dTAF[[II]]230, TAF[[II]]250, d230, Lymphocytic Leukemia, Heterograft, DESC, TAF200, l(3)84Ab, dTAFII250, BG:DS00004.13, TRANSPL HETEROL, TAFII-250, Transplantations, TAF250/230, EfW1, Client, Leukemias, Cell, Symptoms and Signs, T-Cell Leukemia, T cell leukaemia (disease), heterologous transplantation, T-Cell Leukemias, leukaemia (disease) of T cell, dTAF230, dmTAF[[II]]230, Signs and Symptoms, T cell leukemia (disease), TAFII250, XENOTRANSPL, T-Cell, dmTAF1, Taf230, p230, Lymphocytic Leukemias, T-Lymphocytic Leukemia, T-Lymphocytic, TAF[[II]]250/230, TFIID, Finding, T-Cell Lymphocytic, T-Cell Lymphocytic Leukemia, Heterologous Transplantations, T-Cell Lymphocytic Leukemias, T-Lymphocytic Leukemias, TAF250, Lymphocytic, Taf[[II]]250, Xenograft, Taf200, Xenotransplantation, Leukemia, T Lymphocytic, T Cell Leukemia, dTAF[[II]]250, TAF[[II]]230, TFIID TAF250, Transplantation, cel, cell, Heterografts, T, HETEROL TRANSPL, Taf1p, patient, TAF[II]250, Xenografts, CG17603, TAF[[II]], T Lymphocytic Leukemia, T Lymphocytic Leukemias, dTAF250, DmelCG17603, Xenotransplantations, TAF1., Patient, Taf250, leukemia (disease) of T cell, SR3-5, Clients, T Cell, TAF, Clinical Finding, Heterologous, TAF230, Diagnostic Findingsacute T cell lymphoblastic leukemia, T-cell leukemia, Heterograft, precursor T-cell acute lymphoblastic leukemia/lymphoma, Ia antigen-associated invariant chain, lymphoblastic, acute T-cell lymphocytic leukemia, T-Lymphocyte, TRANSPL HETEROL, Precursor T Cell Lymphoblastic Lymphoma, Tnfsf3, dmTAF[[II]]230, relapse, CENP-K, Acute T-Cell Leukemia, T Lymphocyte, diseases, T-Lymphocytic Leukemia, diseases and disorders, Whole Transcriptome, Transcriptome Sequencing, Relapses, Precursor T Cell Lymphoblastic Leukemia, immature T cell, T-ALL, T-Lymphocytic Leukemias, p24ING1c, T-cell acute lymphocytic leukemia, human disease, precursor T-lymphoblastic leukemia (T-cell ALL), TFIID TAF250, cel, T-cell ALL, T-Cells, gC1q-R protein, Complete Exome Sequencing, Recurrences, Whole Transcriptome Sequencing, T, Leucocythemias, T Cells, Xenotransplantations, acute T-cell leukemia, Homo sapiens disease, TNFSF3, precursor T-cell acute lymphoblastic leukemia, Thymus Dependent Lymphocytes, Relapse, dTAF[[II]]230, Acute T-Cell Leukemias, TNFC, Exome, TAF200, TAFII-250, TAF250/230, Acute onset, TAFII250, AI662801, af5alpha, T-Cell, Recrudescence, Diseases, P33, acute T cell leukaemia, acute T cell leukemia, precursor T-lymphoblastic leukemia, C1qBP, Heterologous Transplantations, child, Lymphoblastic Leukemia, T-cell acute lymphocytic leukaemia, Xenograft, Mitochondrial matrix protein p32, T-cell, Leucocythemia, Complete Transcriptome, Xenotransplantation, T Cell Leukemia, Acute T-Lymphocytic Leukemias, Transplantation, Thymus-Dependent, p33, solt, precursor T-cell acute lymphocytic leukemia/lymphoma, Xenografts, Acute T-Lymphocytic Leukemia, T-lymphocyte, CG17603, TAF[[II]], Thymus-Dependent Lymphocyte, Interphase centromere complex protein 37, precursor T-cell acute lymphocytic leukemia, CD74, disease, T cell, Patient, Taf250, SR3-5, Glycoprotein gC1qBP, Cells, Whole Exome Sequencing, Tnfc, p47, T Cell, Transcriptome Sequencings, Hyaluronan-binding protein 1, TAF230, other disease, d230, Thymus-Dependent Lymphocytes, LTbeta, young adult, Lymphocytic Leukemia, Complete Exome, dTAFII250, Transplantations, EfW1, heterologous transplantation, T-Cell Leukemias, precursor T-lymphoblastic lymphoma/leukemia, Solt, T-Cell Acute Lymphocytic Leukemia, dmTAF1, Taf230, leukaemia NOS, T Acute Lymphoblastic Leukemia, disease or disorder, p47ING1a, Leucocythaemia, Precursor T-Cell Lymphoblastic Leukemia, acute T-cell lymphoblastic leukemia, juvenile, TAF250, Ii, Lymphocytic, study, Taf200, WES, Leukemia, Complete, dTAF[[II]]250, Exome Sequencings, cell, Recrudescences, Precursor T-Cell Lymphoblastic Lymphoma, p33ING1b, Heterografts, Taf1p, Recurrences., Sequencing, non-neoplastic, dTAF250, juvenile stage, Whole Exome, Acute T-Lymphocytic, Protein AF-5alpha, Clients, mature T cell, Whole, T-cell lymphoblastic leukemia/lymphoma, disorder, TAF, Acute T-Cell, T Lymphocytes, Lymphocyte, Heterologous, disease remission, HLA-DR antigens-associated invariant chain, TAF[[II]]250, Complete Exome Sequencings, T-cell acute lymphoblastic leukemia, disorders, l(3)84Ab, T acute lymphoblastic leukemia, BG:DS00004.13, medical condition, T-cell type acute leukemia, ASF|SF2-associated protein p32, fksg14, Client, Cell, Leukemias, T-Cell Leukemia, dTAF230, Exome Sequencing, XENOTRANSPL, p230, TAF[[II]]250/230, TFIID, condition, AF5alpha, T lymphocyte, acute T cell lymphocytic leukemia, Acute T Cell, Leucocythaemias, Taf[[II]]250, TAF[[II]]230, Complete Transcriptome Sequencing, p33ING1, Lymphoblastic, Lymphocytes, HETEROL TRANSPL, patient, TAF[II]250, T Lymphocytic Leukemia, DmelCG17603, Acute, Precursor T Cell Lymphoblastic Leukemia Lymphoma, Precursor T Lymphoblastic Leukemia, TAF1falseFinding structural variation from the patient-derived xenografts of pediatric T-cell leukemia at the single-cell levelIn this study, we aimed to identify somatic structural variation of T-cell acute lymphoblastic leukemias (T-ALLs_ from patient-derived xenografts (PDX) at the single-cell level. For this purpose, we performed strand-specific single-cell sequencing of PDX-derived T-ALL relapse samples from two juvenile patients (P1, P33). To validate structural variation detected via scTRIP, we profiled whole exome sequencing (WES) data from P33 (samples taken during initial disease, remission, relapse), and mate-pair sequencing data from P1 (relapse).2022-09-12 16:37:01EGAS000010033659606EGAD00001004499EGAD00001009172EGAD00001008325EGAC00001001091