EGAGenomicsTranscriptome Analysishttps://ega-archive.org/studies/EGAS00001003465EGAEGA study EGAS00001003465Identification of immune mechanisms associated with the high rate of relapse in patient with visceral leishmaniasis and HIV co-infectionEGArestrictedLeishmania Infection, other disease, CPD photolyase activity, Human T-Cell Lymphotropic Virus Type III, post-kala-azar dermal leishmaniasis, PhrB photolyase activity, determination, Blood, AIDS Virus, HTLV-III, Secondary Infections, photoreactivating enzyme activity, pigmented epithelium, Leishmania Infections, Human Immunodeficiency, deoxyribodipyrimidine photolyase activity, Human, Publication., Lymphadenopathy Associated Virus, relapse, diseases, Publication, PBMC, Leishmaniases, Virus, disease or disorder, Whole Transcriptome Shotgun Sequencing, diseases and disorders, 3, stratum pigmentosa retinae, Relapses, NUP96, Human T-Cell Leukemia Virus Type III, epithelium, Human immunodeficiency virus, portion of blood, post-kala-azar dermal infectious disease by leishmaniasis, Human T-Lymphotropic Virus Type III, human disease, MOS3, deoxyribocyclobutadipyrimidine pyrimidine-lyase activity, Viruses, Infections, PRECOCIOUS, Recrudescences, Recurrences, Polymicrobial Infection, Mixed Infection, pigmented retina, F23A5.3, Immunodeficiency Viruses, Secondary Infection, Co infection, Human T Cell Leukemia Virus Type III, DNA cyclobutane dipyrimidine photolyase activity, SUPPRESSOR OF AUXIN RESISTANCE 3, non-neoplastic, post kala-Azar dermal leishmaniasis, Clients, Mixed Infections, Lymphadenopathy-Associated Viruses, disorder, Homo sapiens disease, HIV, Human Immunodeficiency Viruses, F23A5_3, Lymphadenopathy-Associated Virus, cutaneous leishmaniasis (subtype), Relapse, PRE, Human Immunodeficiency Virus, data, Human T Lymphotropic Virus Type III, whole blood, vertebrate blood, Polymicrobial, deoxyribonucleic cyclobutane dipyrimidine photolyase activity, disorders, RNA-seq, medical condition, Client, MODIFIER OF SNC1, AIDS, retinal pigment, Recrudescence, Immunodeficiency Virus, Polymicrobial Infections, chemical analysis, Diseases, deoxyribonucleic photolyase activity, Infection, dipyrimidine photolyase (photosensitive), condition, Coinfections, Mixed, retinal pigment layer, AIDS virus, Acquired Immune Deficiency Syndrome Virus, RPE, Peripheral Blood, Lymphadenopathy-Associated, AIDS Viruses, photolyase activity, LAV-HTLV-III, p. pigmentosa retinae, Reticuloendothelial System, Secondary, disease, phr A photolyase activity, DNA-photoreactivating enzyme, Patient, PBMCs, Acquired Immunodeficiency Syndrome Virus, Co-infection, deoxyribonucleate pyrimidine dimer lyase (photosensitive), assay, Leishmania, visceral leishmaniasis (subtype), Human T Cell Lymphotropic Virus Type III, Co-infections, human immunodeficiency virus infectious diseasecutaneous leishmaniasis (subtype), Relapse, Leishmania Infection, Human T-Cell Lymphotropic Virus Type III, Human Immunodeficiency Virus, post-kala-azar dermal leishmaniasis, Human T Lymphotropic Virus Type III, AIDS Virus, HTLV-III, Infestations and Infections, Leishmania Infections, Client, Human Immunodeficiency, Human, Lymphadenopathy Associated Virus, relapse, AIDS, Recrudescence, Immunodeficiency Virus, Leishmaniases, Infection, Virus, Relapses, Human T-Cell Leukemia Virus Type III, clinical infection., Human immunodeficiency virus, AIDS virus, post-kala-azar dermal infectious disease by leishmaniasis, Acquired Immune Deficiency Syndrome Virus, Human T-Lymphotropic Virus Type III, Lymphadenopathy-Associated, Viruses, AIDS Viruses, Infections, Recrudescences, Recurrences, Immunodeficiency Viruses, Infection and Infestation, patient, Human T Cell Leukemia Virus Type III, LAV-HTLV-III, Infestation and Infection, post kala-Azar dermal leishmaniasis, Patient, Clients, Acquired Immunodeficiency Syndrome Virus, Lymphadenopathy-Associated Viruses, HIV, Infections and Infestations, Leishmania, Human Immunodeficiency Viruses, visceral leishmaniasis (subtype), Human T Cell Lymphotropic Virus Type III, human immunodeficiency virus infectious disease, Lymphadenopathy-Associated VirusfalseIdentification of immune mechanisms associated with the high rate of relapse in patient with visceral leishmaniasis and HIV co infectionRNA-seq transcriptomics of whole blood samples from longitudinal follow-up of a cohort of visceral leishmaniasis (VL) patients with and without HIV coinfection, from active disease through apparent cure and potential relapse. Analysis will identify potential correlates of relapse to identify immune mechanisms underlying the high rate of relapse in HIV/VL coinfection. This data is part of a pre-publication release. For information on the proper use of pre-publication data shared by the Wellcome Trust Sanger Institute (including details of any publication moratoria), please see http://www.sanger.ac.uk/datasharing/2024-07-18 14:00:59EGAS000010034659606EGAD00001008361EGAC00001000205