{"database":"EGA","file_versions":[],"scores":null,"additional":{"omics_type":["Genomics"],"study_type":["Other"],"full_dataset_link":["https://ega-archive.org/studies/EGAS00001003598"],"host":["EGA"],"description":["EGA study EGAS00001003598"],"dataset_title":["Genomic and transcriptomic profiling of carcinogenesis in patients with familial adenomatous polyposis"],"repository":["EGA"],"category":["restricted"],"description_synonyms":["Adenomas, Hereditary Polyposis, Malignant Epithelial Tumors, Tumor, Colus, Familial Adenomatous Polyposis, ADNOS, Epithelial Tumors, Monomorphic Adenomas, Polyposis Syndrome, Adenomatous Polyposis, \"epithelial carcinoma\" EXACT [NCI2004_11_17:C2916], Adenomatous Polyposis Colus, Taenia Coli, Appendix, Granular Cell Adenocarcinoma, Tubular Carcinoma, no subtype (morphologic abnormality)\" EXACT [SNOMEDCT_2005_07_31:68453008], Carcinomatosis, seprase, gene 13, Follicular, Familial Adenomatous Polyposis of the Colon, Cribriform Carcinoma, serine integral membrane protease, Multiple Polyposis, average, fap-A, strong, acinar cell adenoma (morphologic abnormality), Omental Appendix, Spindle-Cell Carcinoma, Follicular Adenoma, Undifferentiated, Adenoma, Familial Intestinal Polyposis, Granular Cell Carcinoma, Tissue, Oncogeneses, Familial, Tubular Carcinomas, benign, Microcystic Adenoma, SIMP, Trabecular., reaction, Polyposes, familial multiple polyposis, Familial Polyposis, Basal Cell Adenoma, fibroblast activation protein alpha, Malignancies, Adenomatous Intestinal Polyposes, Hereditary Polyposis Colus, Myh-Associated Polyposes, Basal Cell Adenomas, Polyposus, Tumors, Papillary Adenomas, Carcinoma, terminal portion of large intestine, hereditary polyposis coli, anatomical protrusion, Undifferentiated Carcinoma, epithelioma, Familial Polyposis Coli, DPPIV, \"carcinoma\" EXACT [CSP2005:2000-1867], Adenomatous, Familial Multiple Polyposus, Hereditary Polyposis Coli, \"carcinoma, Familial Adenomatous Polyposis Coli, Appendix Epiploica, Adenocarcinomas, Anaplastic, Familial Adenomatous Polyposes, Tubular, Benign, Epitheliomas, Malignant Adenoma, Intestinal Polyposis, FPC, Basal Cell Adenocarcinoma, Omental Appendices, Carcinomatoses, Carcinomas, integral membrane serine protease, Spindle Cell, Familial Intestinal Polyposes, acinar cell adenoma, Familial Polyposis of the Colon, Cribriform, initiation, Appendices, Benign Neoplasms, Multiple Polyposi, intestinum rectum, dipeptidyl peptidase FAP, Tubular Adenocarcinomas, Malignant Neoplasms, Papillary, Familial Multiple Polyposes, rectal sac, Patient, Oncogenesis, COLON, spine, Hereditary, Spindle-Cell, Malignant Epithelial Neoplasm, Adenomatous Intestinal Polyposis, FKBPAP, Follicular Adenomas, Trabecular Adenoma, Myh-Associated Polyposis, FAP, Anaplastic Carcinomas, Adenocarcinoma, Familial Multiple Polyposis Syndrome, Tumorigeneses, Trabecular Adenomas, Neoplasms, Oxyphilic Adenocarcinoma, Benign Neoplasm, adenoma, Adenomatous Intestinal, Malignant, Microcystic, Granular Cell Adenocarcinomas, protrusion, 170 kDa melanoma membrane-bound gelatinase, Undifferentiated Carcinomas, Adenomatous Polyposis Coli, Monomorphic, Coli, resilient, rectal part of digestive tract, tough, Myh-Associated, Basal Cell Adenocarcinomas, Intestinal Polyposes, Malignant Epithelial, Epithelioma, rectum, GVM, terminal portion of intestine, study, Microcystic Adenomas, Malignancy, terminal section of digestive tract, Tubular Adenocarcinoma, Epithelial Neoplasms, posterior intestine, Cribriform Carcinomas, Familial Multiple Polyposis, Neoplasias, GLML, Granular Cell Carcinomas, Clients, heterogeneity, malignant Epithelioma, FKBP-associated protein, Familial Polyposis Syndrome, Cancer, FK506-binding protein-associated protein, Oxyphilic, Familial Polyposis Syndromes, Malignant Neoplasm, Myh Associated Polyposis, Multiple Polyposus, Basal Cell, FAP68, Polyposis Colus, Rectums, familial adenomatous polyposis of the colon, Tumorigenesis, Client, FAPalpha, hindgut, Adenomatous Polyposes, VMGLOM, epithelial cancer, \"carcinoma NOS (morphologic abnormality)\" EXACT [SNOMEDCT_2005_07_31:189549006], Trabecular, Neoplasm, Spindle-Cell Carcinomas, Malignant Epithelial Neoplasms, Granular Cell, Oxyphilic Adenocarcinomas, Multiple Polyposes, Adenomatous Polyposis of the Colon, FAP48, Anaplastic Carcinoma, surface-expressed protease, Familial Multiple Polyposi, FAPA, Monomorphic Adenoma, Carcinogeneses, Familial Multiple, patient, Omental, Cancers, Epithelial Neoplasm, Polyposi, Malignant Adenomas, Familial Adenomatous, Papillary Adenoma, Polyposis, Familial Polyposis Colus, Malignant Epithelial Tumor, Epithelial Tumor, Polyposis Coli, Neoplasia, gelatine degradation protease FAP"],"name_synonyms":["Familial Multiple Polyposis Syndrome, d230, Tumorigeneses, Hereditary Polyposis, dTAFII250, Adenomatous Intestinal, Colus, Familial Adenomatous Polyposis, EfW1, dmTAF[[II]]230, Polyposis Syndrome, Adenomatous Polyposis, Adenomatous Polyposis Coli, Coli, dmTAF1, Taf230, Adenomatous Polyposis Colus, Familial., Myh-Associated, Intestinal Polyposes, Familial Adenomatous Polyposis of the Colon, TAF250, Multiple Polyposis, Taf200, dTAF[[II]]250, TFIID TAF250, cel, cell, Familial Intestinal Polyposis, Taf1p, Oncogeneses, Familial, Familial Multiple Polyposis, dTAF250, Polyposes, Clients, familial multiple polyposis, Familial Polyposis, Adenomatous Intestinal Polyposes, Hereditary Polyposis Colus, Myh-Associated Polyposes, TAF, Polyposus, Familial Polyposis Syndrome, Familial Polyposis Syndromes, dTAF[[II]]230, TAF[[II]]250, hereditary polyposis coli, Myh Associated Polyposis, Multiple Polyposus, Familial Polyposis Coli, TAF200, Adenomatous, l(3)84Ab, Polyposis Colus, Familial Multiple Polyposus, Hereditary Polyposis Coli, BG:DS00004.13, TAFII-250, Familial Adenomatous Polyposis Coli, TAF250/230, Tumorigenesis, familial adenomatous polyposis of the colon, Client, Cell, Familial Adenomatous Polyposes, dTAF230, Adenomatous Polyposes, TAFII250, p230, TAF[[II]]250/230, TFIID, Intestinal Polyposis, FPC, Multiple Polyposes, Adenomatous Polyposis of the Colon, Taf[[II]]250, TAF[[II]]230, Familial Multiple Polyposi, Familial Intestinal Polyposes, Carcinogeneses, Familial Multiple, Familial Polyposis of the Colon, TAF[II]250, Multiple Polyposi, CG17603, TAF[[II]], Polyposi, Familial Multiple Polyposes, DmelCG17603, Familial Adenomatous, Taf250, Oncogenesis, Patient, SR3-5, Hereditary, Polyposis, Adenomatous Intestinal Polyposis, Familial Polyposis Colus, Myh-Associated Polyposis, FAP, Polyposis Coli, TAF230, TAF1"],"additional_accession":[]},"is_claimable":false,"name":"Single cell transcriptomic and genomic profiling of carcinogenesis in patients with familial adenomatous polyposis","description":"Familial Adenomatous Polyposis (FAP) is characterized by hundreds to thousands of adenocarcinomas at different evolutional stages in the colon and rectum. Much effort has been made to illuminate the key genomic alterations that facilitate the transition from adenoma to carcinoma. However, the strong heterogeneity of the tumors may hamper these efforts. Here, by sequencing matched adjacent normal tissues, adenomas at different stages and carcinomas from the same patient, we precisely traced the process of colorectal carcinogenesis. Our study offers an accurate genomic landscape during the initiation and progression of carcinogenesis, especially for the transition between adenomas and carcinomas.","dates":{"updated":"2019-11-05 15:52:25"},"accession":"EGAS00001003598","cross_references":{"TAXONOMY":["9606"],"EGA":["EGAD00001005457","EGAC00001000902"]}}