EGAGenomicsOtherhttps://ega-archive.org/studies/EGAS00001003628EGAEGA study EGAS00001003628WES of oral-mucosa-derived organoidsEGArestrictedTherapy, Carcinoma, Radiation Treatments, X-ray therapy, Squamous Cell Carcinoma of the Mouth, Radiation, Malignant Neoplasm, DNS, Squamous Cell Carcinoma of the Nasal Cavity, Targeted Radiation Therapy, Targeted Radiation, (Deoxyribonucleotide)n, Targeted Radiation Therapies, Neoplasms, DNAn+1, exits through, Benign Neoplasm, familial, Squamous Cell Carcinoma of the Head and Neck, Targeted, Radiation Therapies, Head And Neck, Double-Stranded, Tumor, Squamous Cell Carcinoma, Squamous Cell Carcinoma of the Larynx, Malignant, Client, Deoxyribonucleic acids, Hypopharyngeal Squamous Cell Carcinoma, Mutations, (Deoxyribonucleotide)n+m, disease management., Benign, Deoxyribonucleic Acid, Radiotherapy, Neoplasm, Oral Squamous Cell Carcinoma, simple tissue, HNSCC, ds-DNA, radiation therapy, desoxyribose nucleic acid, treatment, Oropharyngeal Squamous Cell Carcinoma, thymus nucleic acid, Malignancy, Laryngeal Squamous Cell Carcinoma, Tissue, Radiotherapies, Benign Neoplasms, carcinoma of the head and neck, Double Stranded, Oral Tongue Squamous Cell Carcinoma, radioisotope therapy, Head And Neck Squamous Cell Carcinomas, Deoxyribonucleic acid, Cancers, Radiation Treatment, Targeted Radiotherapies, Oral Squamous Cell Carcinomas, exposed, Treatments, Malignant Neoplasms, genetic, Neoplasias, extruding from, Oral Cavity Squamous Cell Carcinoma, Organoid, Patient, Therapeutic, Clients, Squamous Cell Carcinoma of Larynx, ds DNA, Desoxyribonukleinsaeure, Radiation Therapy, Therapies, Treatment, Malignancies, Head and Neck Squamous Cell Carcinoma, Double-Stranded DNA, inherited genetic, (Deoxyribonucleotide)m, DNA, deoxyribonucleic acids, Targeted Radiotherapy, DNAn, Squamous Cell of Head and Neck, other neoplasm, constitutitional genetic, hereditary, Neoplasia, Cancer, Tumorsbuccal mucosa, oral mucosa, Mucosa, mouth mucous membrane, Oral, mucous membrane of mouth, Buccal Mucosa, mucosal lining of mouth, Oral Mucosa, oral part of viscerocranial mucosa, Mouth, mouth mucosa, mucosa of mouth, oral mucous membrane, Organoid., mouth organ mucosa, tunica mucosa orisfalseOral mucosa organoids as a potential model for personalized therapiesOrganoids were established from both tumor and matched wildtype tissue from patients diagnosed with head and neck squamous cell carcinoma (HNSCC). In order to confirm tumor status and identify oncogenic driver mutations, DNA derived of these organoids was sequenced. After validation of tumor identity, organoids were exposed to a range of (targeted) chemotherapeutics and radiotherapy. Differential responses to therapeutics were subsequently correlated to underlying genetic alterations to see if DNA mutation status could be predictive for responses to therapy.2021-10-12 20:10:05EGAS000010036289606EGAD00001005063EGAC00001001864