{"database":"EGA","file_versions":[],"scores":null,"additional":{"omics_type":["Genomics"],"study_type":["Other"],"full_dataset_link":["https://ega-archive.org/studies/EGAS00001003651"],"host":["EGA"],"description":["EGA study EGAS00001003651"],"dataset_title":["MultiOMICS study of a pair of infant monozygotic twins with concordant B-cell ALL (WGBS)","MultiOMICS study of a pair of infant monozygotic twins with concordant B-cell ALL (WGS)"],"category":["restricted"],"repository":["EGA"],"name_synonyms":["B cell, study, B-cell, Bursa-Equivalent Lymphocyte, B Cells, B lymphocyte, B-lymphocyte, Infants, B-Lymphocyte, B Lymphocytes, Bursa-Dependent Lymphocytes., Twin"],"description_synonyms":["v-abl, HTRX1, H2S(D2S), B Cells, PhrB photolyase activity, Ableson, Bursa-Dependent Lymphocytes, History, B cell, B acute lymphoblastic leukaemia, Tumor, pigmented epithelium, B-cell lymphoblastic leukaemia, Cxxc7, CG11121, Mutations, precursor B lymphoblastic lymphoma/leukemia, Cbfa2, old, C-abl, Clonal, p150, BCR, 3, CG40494, JTK7, NUP96, epithelium, BCR1, average, Pebp2a2, thymus nucleic acid, B-cell acute lymphoblastic leukaemia, AI325092, Abl, acute B-cell lymphocytic leukemia, ABL, Natural, pigmented retina, Leucocythemias, Evolution, amlcr1, aml1, SO, DNA cyclobutane dipyrimidine photolyase activity, Epigenomic, B-cell acute lymphoblastic leukemia, SUPPRESSOR OF AUXIN RESISTANCE 3, XAML, genetic, AI853148, B lymphocyte, c-Abl, c-ABL, malignant neoplasm, CG4032, abl, B cell acute lymphocytic leukaemia, Malignancies, Double-Stranded DNA, deoxyribonucleic acids, DNAn, AW557856, B-cell acute lymphocytic leukaemia, So, Tumors, PRE, CBF-alpha-2, MLE, B acute lymphoblastic leukemia, B Lymphocytes, Mll, MLL, Am ABL, acute B cell lymphocytic leukaemia, Aml1, deoxyribonucleic cyclobutane dipyrimidine photolyase activity, HRX, AML1, D-Abl, familial, Double-Stranded, Bursa-Dependent Lymphocytes., (Deoxyribonucleotide)n+m, D22S662, Benign, EVI-1, PEBP2aB, retinal pigment, DmelCG11680, mll, dipyrimidine photolyase (photosensitive), mls, D-abl, D-ash, desoxyribose nucleic acid, evi-1, retinal pigment layer, DmelCG4032, AI561783, B-ALL, TET1-MLL, bcr/abl, Leucocythemia, 4674, Epigenetic, All1, WDSTS, common, Benign Neoplasms, AW123102, whole genome, mKIAA4050, CG17960, Malignant Neoplasms, Dsrc7, phr A photolyase activity, DNA-photoreactivating enzyme, nap[ts], B-Lymphocyte, aml-1, ds DNA, inherited genetic, DNA, acute B cell lymphocytic leukemia, Epigenetics, Dmel_CG00000, DNS, (Deoxyribonucleotide)n, abl1, Neoplasms, 5133400C09Rik, Benign Neoplasm, MLL|GAS7, photoreactivating enzyme activity, Malignant, B-cell lymphoblastic leukemia, nap, MLL1A, Deoxyribonucleic acids, l(3)04674, CML, cAbl, CG17617, Deoxyribonucleic Acid, B-cell type acute leukaemia, DmelCG11121, Twin, leukaemia NOS, rhoGAP1A, stratum pigmentosa retinae, Leucocythaemia, leukaemia, DmelCG40494, Runx-1, Somatic, B-cell, MOS3, somda, deoxyribocyclobutadipyrimidine pyrimidine-lyase activity, AMLCR1, dAbl, Malignancy, PRECOCIOUS, D22S11, ALL-1, F23A5.3, Double Stranded, bisulfite, PHL, mak, Deoxyribonucleic acid, EG:23E12.5, Abl1, pebp2ab, B-cell acute lymphocytic leukemia, EG:23E12.2, Mll1, MLL1, Neoplasias, 6430520K01, Karyotypes, Pebpa2b, developmental timing, (Deoxyribonucleotide)m, TEL|ABL, constitutitional genetic, F23A5_3, Cancer, E430008G22Rik, AblK, Drl, ALL, leukemia, B cell acute lymphocytic leukemia, Dabl, Malignant Neoplasm, c-abl, hydrosulfite, DNAn+1, Dash, B-cell type acute leukemia, l(3)73Ba, DAbl, CG11680, MLL/GAS7, Somatic Evolution, Leukemias, Mdu, MODIFIER OF SNC1, MT, mda, CG40453, deoxyribonucleic photolyase activity, Neoplasm, AI462102, aml1-evi-1, ds-DNA, TEL/ABL, cbfa2, ami, Leucocythaemias, aml, acute B-cell lymphocytic leukaemia, AML1-EVI-1, l(3)c-abl, primary cancer, RPE, Cytogenetic, photolyase activity, Xaml1, med, CXXC7, bcr|abl, Bursa-Equivalent Lymphocyte, Cancers, CBFA2, malignant tumor, p. pigmentosa retinae, Ddash/abl, TRX1, DROTKABL3, Desoxyribonukleinsaeure, deoxyribonucleate pyrimidine dimer lyase (photosensitive), mKIAA3017, B-lymphocyte, c-ABL1, TEL, Tel, hereditary, Neoplasia"],"additional_accession":[]},"is_claimable":false,"name":"multi-OMICs study of a pair of infant monozygotic twins with concordant B-cell ALL","description":"B-cell acute lymphoblastic leukemia (B-cell ALL) is the most common cancer in childhood. Studying identical twins with B-cell ALL provides a unique and tractable model for deciphering the developmental timing of pre- and post-natal mutations contributing to clonal evolution. To date, this has mainly focused on major cytogenetic subgroups of childhood B-cell ALL, including MLL fusions, ETV6-RUNX1, hyperdiploidy, and BCR-ABL1. However, formal demonstration of the prenatal origin and “backtracking” the natural history of the leukemia remains understudied in “B-other”/Normal Karyotype (NK) B-cell ALL. To characterize the genetic and the epigenetic landscape of this particular leukemia subtype, we performed whole genome DNA-, B-cell receptor (BCR)-, and DNA bisulfite-sequencing on a pair of 8-month-old monozygotic twins diagnosed with concordant “B-other”/NK B-cell ALL.","dates":{"updated":"2020-07-16 15:33:08"},"accession":"EGAS00001003651","cross_references":{"TAXONOMY":["9606"],"EGA":["EGAD00001005017","EGAD00001005018","EGAC00001001202"]}}