{"database":"EGA","file_versions":[],"scores":null,"additional":{"omics_type":["Genomics"],"study_type":["Transcriptome Analysis"],"full_dataset_link":["https://ega-archive.org/studies/EGAS00001003847"],"host":["EGA"],"description":["EGA study EGAS00001003847"],"dataset_title":["Longitudinal profiling of the immune response to Plasmodium vivax in naive hosts by RNA-sequencing"],"repository":["EGA"],"category":["restricted"],"name_synonyms":["RNA, RNA Sequence Determination, RNA Sequence Analyses, vivax, Haemamoeba vivax, Analyses, Determination, RNA Sequence Determinations, RNA Sequence Analysis, Sequence Determination, RNA Sequence, RNA., Plasmodium, RNA Sequencing, Analysis, malaria parasite P. vivax, Sequence Determinations, Sequencing, Plasmodium vivaxs, Determinations, Sequence Analyses"],"description_synonyms":["host organism, Subset, Ribonucleic, Inflammations, PhrB photolyase activity, PNT-P1, Blood, DmelCG17077, Infestations and Infections, Untrained, EY3-1, T-Lymphocyte, Pnt, pigmented epithelium, prevention, Long Term, Publication., dmTAF[[II]]230, png, diseases, Blood Bank, responsivity, diseases and disorders, 3, NUP96, D-ets-2, 3520, T Cell Subset, prevention and control, Effect, epithelium, Non Polyadenylated, RNA Gene Products, Pnt-P1, Bank, Immune Processes, Immune Responses, human disease, Man (Taxonomy), Gene Expressions, inflammatory response, reference sample, TFIID TAF250, cel, Personnel, developmental field, Tissue, pigmented retina, Untrained Personnel, T-Cell Subset, Banks, Allergy Specialty, DNA cyclobutane dipyrimidine photolyase activity, SUPPRESSOR OF AUXIN RESISTANCE 3, preventive measures, Immune, Voluntary Worker, falciparums, Convalescences, Homo sapiens disease, Lymphoid, Infections and Infestations, Volunteer Personnel, Long-Term Effects, PRE, dTAF[[II]]230, preventive therapy, Process, ribose nucleic acid, Modern, deoxyribonucleic cyclobutane dipyrimidine photolyase activity, Plasmodium, ribonucleic acids, Longterm Effect, Volunteerism, TAF200, D-Ets-2, ets94F, future organ, 0123/09, TAFII-250, TAF250/230, T Lymphocyte Subset, TAFII250, retinal pigment, T-Cell, Voluntary, Ribonukleinsaeure, Diseases, Specialty, dipyrimidine photolyase (photosensitive), pentosenucleic acids, Ribonucleic acids, Lymphoid Cell, T Lymphocyte Subsets, retinal pigment layer, activation, Immunology and Allergy, Plasmodium vivaxs, Acid, pntP2, Pointed-P1, Plasmodium (Laverania) falciparum, Ets94F, lien, Infection and Infestation, T Cell Subsets, CG17603, TAF[[II]], human, ptd, disease, PntP2, phr A photolyase activity, DNA-photoreactivating enzyme, Parasite, Taf250, SR3-5, PntP1, PBMCs, E(E2F)3D, Cells, PNTP2, Innate, PNTP1, TAF230, other disease, Inflammatory Response, 0998/12, d230, human being, Effects, ETS2, Ets2, Gene, dTAFII250, photoreactivating enzyme activity, EfW1, Human, Volunteer Workers, organ field, DMPOINT1A, pntegfr, 0608/07, Homo sapiens, Publication, vivax, dmTAF1, Taf230, PBMC, Gene Products, disease or disorder, field, stratum pigmentosa retinae, Man, TAF250, reactivity, study, Taf200, MOS3, dTAF[[II]]250, deoxyribocyclobutadipyrimidine pyrimidine-lyase activity, pointed-RC, PRECOCIOUS, Longterm, cell, Volunteer Worker, F23A5.3, inflammation, Taf1p, Long-Term, Worker, clinical infection, Expressions, EK3-2, non-neoplastic, Non-Polyadenylated RNA, l(3)07825, dTAF250, Infestation and Infection, Immune Response, Innate Inflammatory Response, Voluntary Workers, disorder, CG17077, Long-Term Effect, Expression, TAF, Plasmodium falciparums, Immune Process, l(3)j1B7, F23A5_3, Lymphocyte, Controlled, Allergy, Controlling, RNA, Ets, TAF[[II]]250, whole blood, disorders, l(3)84Ab, RNS, Subsets, medical condition, BG:DS00004.13, Cell, dTAF230, MODIFIER OF SNC1, yeast nucleic acid, p230, Long Term Effects, deoxyribonucleic photolyase activity, Infection, TAF[[II]]250/230, condition, TFIID, pnt-P1, pnt-P2, l(3)s118306, Lymphoid Cells, T-Lymphocyte Subset, Taf[[II]]250, ribonucleic acid, T-Cell Subsets, Volunteer, RPE, TAF[[II]]230, Peripheral Blood, distinct, Haemamoeba vivax, photolyase activity, prophylaxis, Non Polyadenylated RNA, Non-Polyadenylated, Immunology, TAF[II]250, Ribonucleic Acid, Longterm Effects, p. pigmentosa retinae, Reticuloendothelial System, Ets58AB, DmelCG17603, control, Innate Inflammatory Responses, Modern Man, Response, deoxyribonucleate pyrimidine dimer lyase (photosensitive), response, malaria parasite P. falciparum, malaria parasite P. vivax, Emergency, POINT, CG8705, TAF1"],"additional_accession":[]},"is_claimable":false,"name":"Longitudinal profiling of the immune response to Plasmodium vivax in naive hosts by RNA sequencing","description":"Plasmodium vivax offers unique challenges for control and elimination, and may prove a tougher hurdle to overcome than Plasmodium falciparum. And yet compared to P. falciparum we know very little about the innate and adaptive immune responses that need to be harnessed to reduce disease and transmission. We recently generated a blood bank of a new clonal field isolate of P. vivax (PvW1) for human challenge studies and used systems immunology tools to track the host response throughout infection and convalescence. As part of this study, RNA-sequencing was used to resolve changes in whole blood gene expression through time in 6 volunteers (7-9 time-points per volunteer). In summary, these data show that P. vivax induces two distinct transcriptional programmes in whole blood during and after infection. During infection, transcriptional profiling reveals the rapid mobilisation of an emergency myeloid response, which leads to systemic inflammation and the recruitment of all major T cell subsets into lymphoid tissues. Six days after infection, this innate response subsides and a transcriptional signature of proliferation is revealed. This most likely represents widespread activation of lymphocytes, which return to the circulation after parasite clearance - transcriptional profiling of T cells at this time-point could therefore reveal the outcomes of critical cell-cell interactions that take place within the spleen during infection. This data is part of a pre-publication release. For information on the proper use of pre-publication data shared by the Wellcome Trust Sanger Institute (including details of any publication moratoria), please see http://www.sanger.ac.uk/datasharing/","dates":{"updated":"2021-02-02 17:22:45"},"accession":"EGAS00001003847","cross_references":{"TAXONOMY":["9606"],"EGA":["EGAD00001006924","EGAC00001000205"]}}