{"database":"EGA","file_versions":[],"scores":null,"additional":{"omics_type":["Genomics"],"study_type":["Other"],"full_dataset_link":["https://ega-archive.org/studies/EGAS00001004015"],"host":["EGA"],"description":["EGA study EGAS00001004015"],"dataset_title":["Reconstruction of complex rearrangement patterns causing the initiation of clear cell renal cell carcinoma."],"repository":["EGA"],"category":["restricted"],"name_synonyms":["Adenocarcinoma, Carcinoma, Adenocarcinoma Of, Collecting Duct, Clear Cell Renal Carcinoma., Chromophil Renal Cell Carcinoma, Collecting Duct Carcinomas, Renal Cell Cancers, Renal Cell Carcinomas, Renal Cell Adenocarcinoma, Renal Adenocarcinoma, Renal Adenocarcinomas, Adenocarcinoma Of Kidney, Tumor, Papillary Renal Cell Carcinoma, Renal Cell Carcinoma, Adenocarcinomas, Chromophobe Renal Cell Carcinoma, Collecting Duct Carcinoma of the Kidney, Hypernephroid, Clear Cell Renal Cell Carcinoma, Adenocarcinoma Of Kidneys, Renal Cell Adenocarcinomas, Sarcomatoid Renal Cell Carcinoma, Hypernephroid Carcinomas, Nephroid Carcinomas, Renal Carcinomas, Hypernephroid Carcinoma, Hypernephroma, Grawitz Tumor, Carcinomas, Hypernephromas, Renal Cell, Renal Carcinoma, Kidney, Collecting Duct Carcinoma, initiation, Renal, Nephroid, Clear-cell metastatic renal cell carcinoma, Renal Cell Cancer, Papillary, Collecting Duct Carcinoma (Kidney), Collecting Duct (Kidney), Renal Collecting Duct Carcinoma, Collecting Duct Carcinomas (Kidney), Nephroid Carcinoma, Grawitz, Cancer"],"description_synonyms":["l(1)G0410, beta-cat-arm, Collecting Duct, KIDNEY NEOPL, Phases, kidney tumour, Tumor, Papillary Renal Cell Carcinoma, Divisions, beta-cat, Long Term, renal tumours, kidney (including renal cell) cancer, Adenocarcinoma Of Kidneys, Renal Cell Adenocarcinomas, neoplasm of kidney, 1, Kidney Cancers, renal tumour, Effect, ARM, Kidney Cancer, Arm, beta-Cat, multicellular organismal biosynthetic process, malignant tumour of kidney, single-organism biosynthetic process, thymus nucleic acid, Hypernephromas, M Phases, tumour of the kidney, M, long, Iprit, chromatid, Renal Cancer, Dm Arm, arm, Upper, Division Phase, CG14648, malignant neoplasm, tumor of the kidney, mustard gas, Shattering, malignant tumor of the kidney, Renal Collecting Duct Carcinoma, Double-Stranded DNA, Malignancies, deoxyribonucleic acids, DNAn, TL, malignant kidney neoplasm, Long-Term Effects, malignant kidney tumour, Tumors, Carcinoma, Upper Arms, Adenocarcinoma Of, Growl, Longterm Effect, Renal Cell Adenocarcinoma, beta-catenin/Arm, Adenocarcinoma Of Kidney, Double-Stranded, Nanopore, Cell Divisions, Renal Cell Carcinoma, Adenocarcinomas, (Deoxyribonucleotide)n+m, shortened, Collecting Duct Carcinoma of the Kidney, KU-MEL-1, Clear Cell Renal Cell Carcinoma, bis(2-chloroethyl)sulfane, Benign, tumour of kidney, Chromosome Shattering, renal tumor, desoxyribose nucleic acid, Hypernephroma, Carcinomas, l(1)G0234, renal cancer, tumor of kidney, Kidney, initiation, Benign Neoplasms, whole genome, Nephroid, Clear-cell metastatic renal cell carcinoma, EG:86E4.6, NEOPL KIDNEY, Renal Cell Cancer, Malignant Neoplasms, loss of, NS21, Papillary, Brachiums, Chromosome, kidney (renal) cancer, Patient, betacat, t12687 ALR Dm, Collecting Duct Carcinoma (Kidney), ds DNA, ALDR1, malignant neoplasm of kidney, DmelCG11579, DNA, short, other neoplasm, Nephroid Carcinoma, Clear Cell Renal Carcinoma, Adenocarcinoma, kidney neoplasm (disease), localised, DNS, (Deoxyribonucleotide)n, Effects, malignant tumour of the kidney, Neoplasms, malignant kidney tumor, Renal Cell Cancers, Benign Neoplasm, neoplasm of the kidney, Renal Adenocarcinomas, Yperite, renal neoplasm, Malignant, Deoxyribonucleic acids, Kidney Neoplasms, Cancer of the Kidney, Renal cancer, Hypernephroid, brachium, Deoxyribonucleic Acid, Sarcomatoid Renal Cell Carcinoma, kidney cancer, malignant renal tumour, Hypernephroid Carcinomas, Mustard gas, Renal Carcinomas, Hypernephroid Carcinoma, 1'-thiobis(2-chloroethane), Upper Arm, Grawitz Tumor, Genomes., malignant renal neoplasm, study, Cell Division Phase, Malignancy, Longterm, Collecting Duct Carcinoma, anon-WO0118547.126, Chromothripses, stubby, Double Stranded, Renal, Brachium, Deoxyribonucleic acid, Cell Division, Long-Term, growl, Division, bis(2-chloroethyl) sulphide, Lost, Neoplasias, Clients, Chromosome Shatterings, malignant tumor of kidney, DmelCG14648, Long-Term Effect, (Deoxyribonucleotide)m, Collecting Duct Carcinomas (Kidney), malignant neoplasm of the kidney, l(1)2Bv, sulfur mustard, Grawitz, Cancer, ALR, Malignant Neoplasm, 1-chloro-2-[(2-chloroethyl)thio]ethane, DNAn+1, Chromophil Renal Cell Carcinoma, Collecting Duct Carcinomas, renal tumors, Kidney Neoplasm, Renal Cell Carcinomas, Renal Adenocarcinoma, Client, HEL-S-6, Cell, nev, l(1)arm, Chromophobe Renal Cell Carcinoma, read, prophase chromosome, Cancer of Kidney, MT, Arms, Chromosome 5, Chromosome 3, Long Term Effects, Neoplasm, DD3, focal, Nephroid Carcinomas, Renal Cancers, ds-DNA, M Phase, cancer of kidney, Renal Neoplasms, Phase, primary cancer, RENAL NEOPL, interphase chromosome, Renal Cell, Renal Carcinoma, Senfgas, patient, Cancers, l(1)G0192, malignant tumor, upper extremity, Longterm Effects, CG11579, kidney neoplasm, kidney tumor, Collecting Duct (Kidney), Desoxyribonukleinsaeure, malignant renal tumor, Renal Neoplasm, malignant neoplasm of kidney except pelvis, Neoplasia"],"additional_accession":[]},"is_claimable":false,"name":"Reconstruction of complex rearrangement patterns causing the initiation of clear cell renal cell carcinoma.","description":"The genomic hallmark of clear cell renal cell carcinoma is the loss of the short arm of chromosome three. This appears to be the earliest genomic event in the formation of these cancers. Often chromosome 3 is lost at the same time as part of chromosome 5 is duplicated via an unbalanced translocation, often with features consistent with focal chromothripsis. In this study, we sought to reconstruct the chromothriptic event that underlies the initiation of kidney cancer. We used long read sequencing (promethION, Oxford Nanopore Technologies) of patient tumour-derived DNA to elucidate how a single cell division error can generate cancer genome complexity.","dates":{"updated":"2020-04-20 18:52:18"},"accession":"EGAS00001004015","cross_references":{"TAXONOMY":["9606"],"EGA":["EGAD00001005495","EGAC00001000000"]}}