{"database":"EGA","file_versions":[],"scores":null,"additional":{"omics_type":["Genomics"],"study_type":["Cancer Genomics"],"full_dataset_link":["https://ega-archive.org/studies/EGAS00001004366"],"host":["EGA"],"description":["EGA study EGAS00001004366"],"dataset_title":["Whole exome sequencing of endometriod ovarian cancer tumours"],"repository":["EGA"],"category":["restricted"],"name_synonyms":["ovarian epithelial cancer, Ovarian carcinoma, ovarian cancer."],"description_synonyms":["Dm DWnt3/5, DmErk, extracellular signal-regulated kinase activity, RAS, Ras, DWnt-5, pp44mapk, l(1)G0098, Materials, DWnt-4, dP60, Vps34, DPTEN, A4, l(2)wg, BcDNA:LD15217, Progress Reports, Ras-1, Diagnosis, VPS34, 11621, P270, Prp4 protein kinase activity, Mutations, PI-3 kinase, p110-alpha, wnt-4, ovarian cancer, ras, LeMPK3, c-ras2, int-1, ATP-protein transphosphorylase activity, Summary Report, p44mpk, bbl, Dm-1, Dm-2, Dm-3, ATP:protein phosphotransferase (non-specific) activity, symptoms, DmelCG1916, Dp38, Whole Transcriptome, Transcriptome Sequencing, TEP1, Catnb, SAPK2, SEM, Sem, MAP-k, gamma sarcoglycan, Dp60, I, Progress Report, BCC7, pp42, PI3K_59F, Dsor2, PI3-kinase activity, sem, D17Mit170, WNT, Wnt, PI3Kgamma, MCAP, set, Field Reports, PI3K 68D, Br, dWnt2, stage, ELD, wnt, Diagnose, ATP - 1-phosphatidyl-1D-myo-inositol 3-phosphotransferase activity, Bfc, CG1799, ERK-A, p82 kinase activity, hOSA1, screening, dVps34, dpERK, dpErk, Ras2, RAS2, Ras1, RAS1, rea, Exome, betaIIPKC, p50alpha, DmMAPK, armadillo, PMK-2, dp-ERK, PMK-1, Tl3, Tl2, CG2699, DmelCG5373, Diagnoses, PMK-3, Wee-kinase activity, Postmortem, C530050K14, PTEN3, PTEN1, D-wnt-2, Algorithm, type-1 PI3K, dRas85D, pMAPK, pMapK, sarcoglycan, bfy, ras1, ras2, CG4889, BcDNA:RE36103, fg, long patch mismatch repair system, CG11621, Complete Transcriptome, DmERKA, rl/MAPK, death rate, Field, Osa1, OSA1, Mismatch Repair, Hras-1, signs, non-specific serine/threonine protein kinase activity, Dm Ras1, l(2)41Ac, PTENa, surveillance, DmelCG4141, F8A5_4, APDS, RasI, Report, CT34260, dpERk, Material, 35kD dystrophin-associated glycoprotein, serine-specific protein kinase activity, PI3KBETA, Whole Exome Sequencing, SAPK, HIPK2, cytidine 3', bhy, DNA, other neoplasm, Wee 1-like kinase activity, Harvey-ras, Hras1, 2310035O07Rik, glycogen synthase A kinase activity, GLM2, dRas, developmental stage, glycogen synthase kinase 3 activity, CG1167, 12559, H-ras, DRAS1, DRas2, IMPDH, protein-containing complex, PRO2286, LFS1, phosphorylase b kinase kinase activity, LD06825, EK2-1, Dras2, Dras1, PIK3, D-Ras, dVps34/PI3K59F, Pi3Kp60, PI3K-dp110, AI463227, Gene Products, Screening, Kras-2, dPI3K, anon-92Ed, Antemortem, MAM, gamma-SG, ctnnb, IMPdH, ribosomal protein S6 kinase II activity, Ha-ras, Erk, ERK, PRKM1, Dras, class I, ras 1, PRKM2, protein-serine kinase activity, Complete, Exome Sequencings, DmelCG6407, occurrence, raspberry/impd, prevalence, STK32, BAF250, DNA Mismatch, dWnt, Diagnoses and Examinations, Ras[V12], Pi3Kp110, EK3-4, DmelCG5671, Sequencing, erk, DRas, P110BETA, DRas85D/Ras, Dmras64B, Whole Exome, Wnt3/5, DmelCG4698, PI3K21B, protein-cysteine kinase activity, Whole, Hpr kinase activity, B430203M17Rik, rll, MCM, STK26, CRCS12, Investigative Reports, p38-2, myelin basic protein kinase activity, Cpk, Antemortem Diagnoses, SMARCF1, findings, Complete Exome Sequencings, PTEN, cou, grupo, BM029, AA414921, 35 kDa dystrophin-associated glycoprotein, l(2)rO727, class II, type III phosphoinositide 3-kinase activity, Proteins, stress-activated kinase activity, MAP-2 kinase activity, dPten, pten, protein serine kinase activity, D-ras-1, PI(3)K, SGCG, protein phosphokinase activity, cpk, E(faf), PI3K-92E/Dp110, Exome Sequencing, dpten, DmelCG1167, PIK3C1, Lr, spd, PKA, native protein, CWS5, PKC, FILS, 1110030E03Rik, CWS1, stress-activated protein kinase activity, Research Reports, mapk2, mapk1, S35097, dPTEN, outbreaks, protein kinase p58 activity, serine/threonine protein kinase activity, MRD14, MRD19, RAS85D, Mmac, CG12559, Dmras85D, DMDA1, CG5671, ensemble, l(1)9Eb, CG4698, dpERK1, DmelCG11621, dsk1, 5'-cyclic monophosphate-responsive protein kinase activity, atypical PKC activity, Gene Proteins, caPI3K, CLOVE, Reports, dpMAPK, DmVps34, IMD14, PI3K_68D, PI3K-92D, Bra, epidemics, Dmp110, DWnt-3, DWnt-2, DWnt-1, protein serine-threonine kinase activity, SAP kinase activity, CG6407, glycogen synthase kinase activity, MGC130048, Ras1/RAs85D, Antemortem Diagnosis, protein kinase A activity, CG5373, ATVPS34, Dint-1, DmelCG4889, Mpk2, Smarcf1, PI3K, p42mapk, c-rasHa, E(sev)3C, Dp110, protein, Repair, Tp53, CG11485, SR2-1, BAF250a, PHOSPHATIDYLINOSITOL 3-KINASE, DmelCG2699, F8A5.4, Mesc, kinase-related transforming protein, p110alpha, mitogen-activated protein kinase activity, phosphatidylinositol 3-kinase activity, Dm Wg, protein aggregate, Wnt-4, mpk1, Summary Reports, l(2)02657, Wnt-1, D-Ras1, Wnt-3, Wnt-2, me75, ctnnb1, Erk/Map kinase, RTK, Pi3K92D, CG4141, Complete Exome Sequencing, Whole Transcriptome Sequencing, l(1)G0436, catalyst activity, DERK-A, Pi3k, ras85B, ras85D, E(sina)7, PI[[3]]K, Rl, DWnt5, DWnt4, T1, DWnt3, DWnt2, Raf kinase activity, Progress, MP kinase activity, serine kinase activity, DERK, D-ras-2, p55alpha, atypical protein kinase C activity, Dwnt5, Dwnt4, MBP kinase II activity, Therapies, gamma-sarcoglycan, mitogen-activated S6 kinase activity, protein-aspartyl kinase activity, dERK, Pi3K, PI3k, MCMTC, Mismatch, Sp, Therapy, l(3)s1747, PI3K68D, MAP kinase 2 activity, Mapk, Ki-ras, P110DELTA, PtdIns-3-kinase activity, frequency, SG-gamma, Erk1, ERK1, ERK2, mapk1a, vacuolar protein sorting 34, beta-catenin, dPIK, 1-phosphatidylinositol 3-kinase activity, M phase-specific cdc2 kinase activity, Screenings, clone 2.4, Investigative Report, mapk1b, MapK, MAPK, Examinations and Diagnoses, Genetic Materials, B120, p21[Ras1], dRas1, dRAS1, Postmortem Diagnosis, DWint-1, serine protein kinase activity, erk2, Dras85D, Genetic Material, mapk, ras-2, DWnt3/5, Diagnoses and Examination, ERKa, phosphorylase B kinase kinase activity, Ovarian carcinoma, Postmortem Diagnoses, l(1)G0351, LD02673, BcDNA:RE08694, mismatch repair, protein glutamyl kinase activity, anon-WO03040301.228, p85alpha, DmelCG1799, l(2R)EMS45-39, c-Ha-ras, MMAC1, anon-EST:Liang-2.4, D-ras1, l(1)G0238, D-ras2, WG, DmelCG12559, C-ras1, p38, Dras64B, PI3K 68_D, gamma (35kDa dystrophin-associated glycoprotein), morbidity, C-ras2, l(3)06677, DpErk, DpERK, l(1)G0002, ErkA, ERKA, hydroxyalkyl-protein kinase activity, l(1)G0482, CG1916, WEE1Hu, p110D, DMDA, c-H-ras, epsilon PKC, l(1)G0127, P53, Wg, p44, Cistron, p120-PI3K, Transcriptome Sequencings, BZS, droPIK57, pERK, Gruppe, ribosomal S6 protein kinase activity, calcium/phospholipid-dependent protein kinase activity, SGCG_HUMAN, GroupII, RasV12, Complete Exome, PI3K92E, p53, Kras2, Gene, Pi3K_59F, DmelCG9375, type I phosphatidylinositol kinase activity, TYPE, DWnt-3/5, phosphatidylinositol 3-kinase, DAGA4, l(1)G0388, MHAM, hELD, Investigative, p60, 35DAG, Mass, serine(threonine) protein kinase activity, PHOSPATIDYLINOSITOL 3-KINASE, Low, SCG3, l(1)G0380, Dp110/PI3K, T-antigen kinase activity, PI3K-68D/E, p21B, galactosyltransferase-associated kinase activity, study, WES, dras1, Dm-ras-64B, MutS/MutL/MutH pathway, Genetic, xp42, Treatments., PI3'K, l(1)G0391, Wnt/Wg, p42 mitogen-activated protein kinase activity, Wnt1, CG18732, ATP:protein phosphotransferase (MAPKK-activated) activity, Wnt3, wnt4, wnt3, wnt2, Ras 85D, wnt1, protein kinase (phosphorylating) activity, PI3K-68D, Trp53, OK/SW-cl.35, grupos, Raf-1, time of survival, wnt5, DmERK-A, TRP53, ras-l, casein kinase (phosphorylating) activity, incidence, l(1)G0056, dP110, ert1, 6330412C24Rik, CG9375, protein complex, p120, prkm2, prkm1, CT39192, p110, K-ras, Vps34p, Cistrons, Examination and Diagnoses, wgl, LGMD2C, Xp53, group, p38delta, twitchin kinase activity, fs(3)05703, CTNNB, ATP:1-phosphatidyl-1D-myo-inositol 3-phosphotransferase activity, survival, vps34, Mass Screenings, EP(X)1093, Protein, AP50 kinase activity, MBP kinase I activity, dp110, AI929937, PI3CG, Xp42, PI-3-K, threonine-specific protein kinase activity, C1orf4, PI3K-59F, Complete Transcriptome Sequencing, 10q23del, distinct, PI3K-Dp110, mitogen activated kinase activity, Su(Raf)2B, Rest, class III, ovarian epithelial cancer, Dwnt-2, Dwnt-3, MutL-like pathway, EY2-2, A130070J02Rik, p110gamma, Dm DWnt2, Su(tor)3-2, endemics, Dm DWnt4, Protein Gene Products, DEC, D-ERK, Therapeutic, Dwnt-5, SCARMD2, Treatment, POLE1, Summary, groupe, Field Report, Gla, MAP kinase 1 activity, A-kinase activity"],"additional_accession":[]},"is_claimable":false,"name":"Molecular stratification of endometrioid ovarian carcinoma predicts clinical outcome","description":"Endometrioid ovarian carcinoma (EnOC) is an under-investigated type of ovarian carcinoma. Here, we report the largest genomic study of EnOCs to date, performing whole exome sequencing of 112 cases following rigorous pathological assessment. High frequencies of mutation were detected in CTNNB1(43%), PIK3CA(43%), ARID1A(36%), PTEN(29%), TP53(26%) and SOX8(19%), a novel target of recurrent mutation in EnOC. POLE and mismatch repair protein-encoding genes were mutated at lower frequency (6%, 18%) with significant co-occurrence. A molecular taxonomy was constructed using a novel algorithm (PRISTINE), identifying clinically distinct EnOC subtypes: TP53m cases demonstrated greater genomic complexity, were frequently FIGO stage III/IV at diagnosis (48%) and incompletely debulked (44%), and demonstrated inferior survival; conversely, CTNNB1m cases demonstrated low complexity and excellent clinical outcome, were predominantly stage I/II at diagnosis (89%) and completely resected (87%). Tumour complexity provides further resolution within the TP53wt/CTNNB1wt group. Moreover, we identify the WNT, MAPK/RAS and PI3K pathways as good candidate targets for molecular therapeutics in EnOC.","dates":{"updated":"2020-09-08 11:23:52"},"accession":"EGAS00001004366","cross_references":{"TAXONOMY":["9606"],"EGA":["EGAD00001006389","EGAC00001001588"]}}