{"database":"EGA","file_versions":[],"scores":null,"additional":{"omics_type":["Genomics"],"study_type":["RNASeq"],"submitter_keywords":["COVID-19","2019 novel coronavirus infection","SARS-CoV-2","2019-nCoV infection","severe acute respiratory syndrome coronavirus 2","coronavirus disease 2019","SARS-coronavirus 2"],"full_dataset_link":["https://ega-archive.org/studies/EGAS00001004503"],"host":["EGA"],"description":["EGA study EGAS00001004503"],"dataset_title":["Peripheral immunoprofiling of stratifies COVID-19 patients based on disease-specific neutrophil signatures"],"repository":["EGA"],"category":["restricted"],"name_synonyms":["COVID19, other disease, polynuclear neutrophilic leukocyte, Disease, Leukocyte, Coronavirus Disease 19, Band Cell, β-CoV, Polymorphonuclear Neutrophils, beta-CoV, Leukocytes, COVID-19, disorders, SARS-CoV-2, Virus Infection, COVID-19 Virus Diseases, 2019 novel coronavirus, medical condition, 2019 Novel Coronavirus Disease, SARS-CoV-2 Infections, 2019 nCoV Infection, COVID 19 Virus Infection, Virus Disease, Client, Polymorphonuclear Leukocyte, Cell, 2019 nCoV Disease, Polymorphonuclear, COVID-19 Virus Disease, 2019-nCoV Infection, Neutrophil Band Cell, neutrophil granulocyte, neutrocyte, neutrophilic leucocyte, LE Cells, diseases, 2019-nCoV Disease, neutrophil leukocyte, SARS CoV 2 Infection, Diseases, Infection, Severe Acute Respiratory Syndrome Coronavirus 2 Infection, disease or disorder, condition, Coronavirus, diseases and disorders, LE Cell, COVID-19 Virus Infections, β-coronavirus, 2019-nCoV, COVID 19 Pandemic, Neutrophil Band Cells, Polymorphonuclear Neutrophil, human disease, β-CoVs, betacoronavirus, Disease 2019, Pandemic, neutrophilic granulocyte, neutrophil leucocyte, COVID-19 Virus Infection, Coronavirus Disease 2019, severe acute respiratory syndrome coronavirus 2, Coronavirus Disease-19, neutrophilic leukocyte, COVID-19 Pandemics, SARS-CoV-2 Infection, COVID-19 Pandemic, beta-CoVs, SARS-coronavirus 2, non-neoplastic, COVID-19 Virus, disease, Patient, Clients, polymorphonuclear leukocyte, polynuclear neutrophilic leucocyte, Polymorphonuclear Leukocytes, PMN, disorder, polymorphonuclear leucocyte, 2019 Novel Coronavirus Infection, Homo sapiens disease, 2019-nCoV Diseases, polymorphonuclear neutrophil., poly, LE, COVID 19 Virus Disease, SARS Coronavirus 2 Infection, Neutrophil, COVID 19, 2019-nCoV Infections"],"description_synonyms":["COVID19, influenza infection, host organism, Influenza with other manifestations, Granulocyte, Immune Systems, Hypercapnic Respiratory, Influenza with other manifestations NOS (disorder), Blood, COVID-19, Virus Infection, Acute Hypercapnic Respiratory Failure, 2019 novel coronavirus, COVID-19 Virus Diseases, Hypoxemic Acute Respiratory Failure, SARS CoV 2 Virus, s., Virus Disease, COVID19 Virus, 2019 nCoV Disease, Failure, Respiratory Failures, prevention, Cytokine Storms, Human, Readability, Depressions, SARS, granular leucocyte, 2019-nCoV Disease, PBMC, Ventilatory Depression, Novel Coronavirus, SARS CoV 2 Infection, Virus, symptoms, Severe Acute Respiratory Syndrome Coronavirus 2 Infection, Hypercytokinemia, β-coronavirus, prevention and control, agranular plasmatocyte, 2019-nCoV, COVID 19 Pandemic, 2019 Novel Coronaviruses, SARS Coronavirus 2, β-CoVs, Viruses, reference sample, BLU, Respiratory Failure, Flu, FLU, Wuhan Seafood Market Pneumonia Virus, COVID-19 Virus Infection, chronic respiratory failure, Coronavirus Disease 2019, Tissue, Hypoxemic Respiratory, Hypoxemic Respiratory Failure, severe acute respiratory syndrome coronavirus 2, Coronavirus Disease-19, Cytokine Release Syndromes, beta-CoVs, SARS-CoV-2 Infection, Acute Hypoxemic Respiratory Failure, acute and chronic respiratory failure, Transplant Donors, preventive measures, CILD22, COVID-19 Virus, Cytokine Storm Syndrome, Immune, lamellocyte, Respiratory, Clients, polymorphonuclear leukocyte, flu, Tissue Donor, Influenza, Influenza with non-respiratory manifestation (disorder), Hypercapnic Acute Respiratory Failure, Ovum Donor, Grippe, Influenza with other manifestations (disorder), COVID 19 Virus Disease, SARS Coronavirus 2 Infection, Wuhan Coronavirus, orthomyxoviridae disease or disorder, Controlled, 2019-nCoV Infections, Organ, screening, Disease, Controlling, SARS-CoV-2 Viruses, Coronavirus Disease 19, Hypoxemic Respiratory Failures, preventive therapy, Transplant Donor, 2019 Novel Coronavirus, β-CoV, findings, whole blood, beta-CoV, granular leukocyte, COVID-19 Viruses, typical plasmatocyte, Transplant, Cytokine Storm, SARS-CoV-2, Hypercapnic, Semen Donors, Coronavirus 2, 2019 Novel Coronavirus Disease, SARS-CoV-2 Infections, influenza with non-respiratory manifestation, 2019 nCoV Infection, COVID 19 Virus Infection, Client, COVID-19 Virus Disease, 2019-nCoV Infection, COVID19 Viruses, Severe Acute Respiratory Syndrome Coronavirus 2, SARS-CoV-2 Virus, orthomyxoviridae caused disease or disorder, acute-on-chronic respiratory failure, Systems, Ventilatory, Infection, Coronavirus, Donor, Donors, COVID-19 Virus Infections, influenza, 2019 Novel, betacoronavirus, Disease 2019, Peripheral Blood, Pandemic, Organ Donor, Coronavirus Disease 2019 Virus, prophylaxis, System, Hypercapnic Respiratory Failures, Hypoxemic, signs, acute respiratory failure, influenza virus infection, Wuhan, Understanding, COVID-19 Pandemics, COVID-19 Pandemic, SARS-coronavirus 2, Semen Donor, orthomyxoviridae infectious disease, Reticuloendothelial System, Respiratory Depression, Semen, Patient, control, PBMCs, granulocyte, 2019, Hypercytokinemias, 2019 Novel Coronavirus Infection, Hypercapnic Respiratory Failure, COVID 19 Virus, 2019-nCoV Diseases, Ovum, Ovum Donors, Organ Donors, COVID 19, Severe"],"additional_accession":[]},"is_claimable":false,"name":"Peripheral immunoprofiling of stratifies COVID-19 patients based on disease-specific neutrophil signatures","description":"The SARS-CoV-2 pandemic has led to increasing numbers of COVID-19 patients all over the world. Aetiopathologies range from no symptoms, mild flu-like to severe cases succumbing to respiratory failure. Reports on a dysregulated immune system in the severe cases, showing similarities to cytokine release syndrome, calls for better characterization and understanding of the changes in the immune system as well as their variance across COVID-19 patients in order to be able to design according to host-directed therapies. Here, we profiled blood transcriptomes of 39 COVID-19 patients and 10 control donors. Enriched granulocyte signatures in whole blood samples were verified in granulocyte samples from 49 COVID-19 patients in a second cohort.","dates":{"updated":"2020-12-09 10:32:29"},"accession":"EGAS00001004503","cross_references":{"TAXONOMY":["9606"],"OLS":["MONDO_0100096"],"EGA":["EGAD00001006671","EGAD00001006326","EGAC00001001640"]}}