EGAGenomicsTranscriptome Analysishttps://ega-archive.org/studies/EGAS00001004534EGAEGA study EGAS00001004534COMPARZEGArestrictedassay, determination, chemical analysis, Intervention Study.Adenocarcinoma, Materials, clear cell renal cell adenocarcinoma, Collecting Duct, SU 011248, determination, Metastasis, Mortality Declines, SU 11248, TKI inhibitor, Renal Cell Cancers, Excess, Gene, adenocarcinoma of kidney, Neoplasm Metastases, Progress Reports, neoplasm metastasis, Renal Adenocarcinomas, Crude Mortality Rate, Tumor, Papillary Renal Cell Carcinoma, mortality measurement, CCRCC, cancer metastasis, Age-Specific Death, Case Fatality Rates, Mortality Determinants, Crude, Death Rates, Hypernephroid, Adenocarcinoma Of Kidneys, Rate, Determinant, Investigative, Renal Cell Adenocarcinomas, Kinase Inhibitors, Tyrosine Kinase Inhibitor, Summary Report, Sarcomatoid Renal Cell Carcinoma, responsivity, Sutent, Case Fatality, RCC, Hypernephroid Carcinomas, Inhibitors, Excess Mortalities, Renal Carcinomas, Hypernephroid Carcinoma, hypernephroma, Summary Reports, Grawitz Tumor, GW786034B, treatment, Differential Mortality, reactivity, tumor cell migration, Excess Mortality, Hypernephromas, TKI inhibitors, pazopanibum, Genetic, Progress Report, Crude Mortality Rates, GW 786034B, Collecting Duct Carcinoma, tyrosine kinase inhibitors, metastasis, Renal, GW 780604, GW786034, Clear Cells, Age-Specific, Progress, clear cell renal cell carcinoma, GW 78603, Field Reports, protein tyrosine kinase inhibitors, CFR Case Fatality Rate, Clients, GW780604, Mortality Rates, mortality rate, disease management, Crude Death Rates, Therapies, Renal Collecting Duct Carcinoma, associated, Age-Specific Death Rate, Sunitinib Malate, Investigative Reports, Collecting Duct Carcinomas (Kidney), tyrphostin, Age Specific Death Rate, tumor metastasis, Grawitz, Cancer, Tyrosine Protein Kinase Inhibitors, Therapy, sunitinibum, Carcinoma, Adenocarcinoma Of, Mortality Decline, 5-(5-Fluoro-2-oxo-1, SU11248, Metastases, Chromophil Renal Cell Carcinoma, Collecting Duct Carcinomas, Crude Death, Renal Cell Carcinomas, Renal Cell Adenocarcinoma, GW-780604, Renal Adenocarcinoma, Adenocarcinoma Of Kidney, Votrient, Cistrons, Renal Cell Carcinoma, Adenocarcinomas, Client, TKI Tyrosine Kinase Inhibitors, results, Crude Mortality, Tyrosine, sunitinib, Metastase, Chromophobe Renal Cell Carcinoma, Collecting Duct Carcinoma of the Kidney, Case Fatality Rate, GW-786034B, renal cell adenocarcinoma, Clear Cell Renal Cell Carcinoma, Mortality, survival, Investigative Report, Research Reports, chemical analysis, SU-011248, Neoplasm, protein tyrosine kinase inhibitor, tyrphostins, Genetic Materials, Nephroid Carcinomas, Determinants, Death, 4-dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)amide, Hypernephroma, Genetic Material, Carcinomas, Rates, Death Rate, kidney adenocarcinoma, death rate, distinct, Renal Cell, Renal Carcinoma, Kidney, Field, Mortalities, Nephroid, Age-Specific Death Rates, Treatments, Renal Cell Cancer, Tyrosine Kinase, Papillary, Differential, metastatic, Report, Mortality Rate, Crude Death Rate, Patient, Reports, Therapeutic, Material, Collecting Duct Carcinoma (Kidney), pazopanib, time of survival., Collecting Duct (Kidney), SU-11248, SU011248, Decline, renal cell carcinoma, microarray, Treatment, Cistron, assay, response, Mortality Determinant, Summary, 2-dihydroindolylidenemethyl)-2, Nephroid Carcinoma, Differential Mortalities, Field Report, Clear Cell Renal CarcinomafalseTranscriptomic analysis of the Phase 3 COMPARZ clinical trialMetastasis remains the main reason for renal cell carcinoma (RCC)-associated mortality. Tyrosine kinase inhibitors (TKI) impart clinical benefit for most RCC patients but the determinants of response are poorly understood. We report an integrated genomic and transcriptomic analysis of metastatic clear cell RCC (ccRCC) patients treated with TKI therapy and identify predictors of response. Patients in the COMPARZ phase III trial received first-line sunitinib or pazopanib with comparable efficacy. Microarray-based transcriptomic analyses with results from Next-gen genomic analyses of targeted genes revealed distinct molecular subgroups associated with response and survival.2020-07-16 10:51:52EGAS000010045349606EGAD00010001930EGAC00001001657