EGAGenomicsRNASeqhttps://ega-archive.org/studies/EGAS00001004562EGAEGA study EGAS00001004562RNAseq of NSCLC and melanoma tumor xenografts treated with ADCEGArestrictedADC, AIDS-related Dementia, AIDS - Acquired immune deficiency syndrome dementia complex, AIDS Encephalopathies, BG:DS00941.5, acquired immune deficiency syndrome-related dementia, Encephalopathies, AIDS-related, neoplasia, Neoplasms, ADC - Acquired immune deficiency syndrome dementia complex, Cdx, neoplastic disease, GAD[[2]], cDNA 1, Tumor, DEMENTIA COMPLEX AIDS RELAT, HIV Associated Cognitive Motor Complex, tumours, AIDS related cognitive impairment, NEOPL, HIV-1 Cognitive and Motor Complex, HuADC, Cdx-1, AIDS Encephalopathy, neoplastic growth, acquired immune deficiency syndrome dementia complex, Acquired-Immune Deficiency Syndrome Dementia Complex, AIDS, AIDS related Dementia Complex, HIV Encephalopathies, AIDS Dementia Complex, AIDS-related Dementia Complex, Acquired immune deficiency syndrome dementia complex, HIV-associated dementia, Dementia associated with AIDS, HIV 1 Cognitive and Motor Complex, neoplasm, Glutamate decarboxylase-like protein 1, HIV Dementias, HuCSADC, Dementia Complex, Dementia, HIV encephalitis, odc1-b, AIDS with dementia (disorder), DmelCG7811, odc1l, CSADC, HIV-1-Associated Cognitive Motor Complex., 4.1.1.11, cell process disease, tumor disease, neoplasm (disease), Complex, azi2, Acquired Immune Deficiency Syndrome, AIDS Dementia, Cysteine sulfinic acid decarboxylase, HIV-Associated Cognitive Motor Complex, DGad2, Dementias, tumour, Encephalopathy, odc-p, DmGad2, disease of cellular proliferation, HIV 1 Associated Cognitive Motor Complex, Aspartate 1-decarboxylase, DEMENTIA COMPLEX ACQUIRED IMMUNE DEFIC SYNDROME, MALIGNANT AND UNSPECIFIED (INCL CYSTS AND POLYPS), 4.1.1.29, AIDS RELAT DEMENTIA COMPLEX, Gad2, anon-34Db, AIDS related, 1110027M19Rik, HIV ASSOC COGNITIVE MOTOR COMPLEX, HIV Dementia, CG7811, HIV associated cognitive and motor complex, HIV, HIV Encephalopathy, tumor, odc2, other neoplasm, NEOPLASMS BENIGN, Neoplastic Growth, Neoplasia, Acquired immune deficiency syndrome-related dementia, Dementia associated with acquired immunodeficiency syndrome, TumorsMalignant tumor of lung, BG:DS00941.5, insensitive, Product, Tyro7, malignant tumor of lung, B-cell receptor complex, cDNA 1, malignant neoplasm of the lung, Tumor, JTK11, HIV Associated Cognitive Motor Complex, HuADC, acquired immune deficiency syndrome dementia complex, Acquired-Immune Deficiency Syndrome Dementia Complex, RPL23, melanoma, Pharmaceutical Product, HIV 1 Cognitive and Motor Complex, ARK, Ark, Pulmonary cancer, AIDS with dementia (disorder), treatment, odc1l, Lung Cancer, increased, inflammatory response, membrane bound, alveolar cell carcinoma, Acquired Immune Deficiency Syndrome, AIDS Dementia, HIV-Associated Cognitive Motor Complex, Lung Cancers, HIV 1 Associated Cognitive Motor Complex, resistance to, Immunogenic, Malignant neoplasm of lung, AIDS RELAT DEMENTIA COMPLEX, medicine, Pharmaceutical, HIV ASSOC COGNITIVE MOTOR COMPLEX, disease management, Therapies, Malignancies, B-lymphocyte receptor complex, somatic mutation, HIV-1-Associated Cognitive Motor Complex, Tumors, ADC, Therapy, AIDS - Acquired immune deficiency syndrome dementia complex, AIDS Encephalopathies, Lung cancer, acquired immune deficiency syndrome-related dementia, SLEB2, Cancer of Lung, GAD[[2]], Malignant Melanomas, antibodies, somatic, AIDS related cognitive impairment, AI323647, Benign, Melanoma, AIDS, rpl17a, cancer of lung, pd-1, Acquired immune deficiency syndrome dementia complex, Malignant lung tumor, malignant tumour of lung, Pharmaceutic, HIV-associated dementia, HIV Dementias, PD1, PD-1, AXR1-like, Dementia, odc1-b, Lung malignant tumors, malignant lung neoplasm, Immunotherapies, resistant, 4.1.1.11, adenocarcinoma of lung, azi2, susceptibility to, DGad2, Benign Neoplasms, Dementias, rpl23, Encephalopathy, Cell Death, DmGad2, Treatments, hPD-1, Malignant Neoplasms, DEMENTIA COMPLEX ACQUIRED IMMUNE DEFIC SYNDROME, response to tyrosine kinase inhibitor in, Phenotypes, 4.1.1.29, immunoglobulin, hPD-l, B cell receptor accessory molecule complex, Gad2, 1110027M19Rik, hSLE1, B lymphocyte receptor complex, rpl17, HIV Encephalopathy, Cancer of the Lung, lung neoplasm, odc2, other neoplasm, accessory, Dementia associated with acquired immunodeficiency syndrome, Cancer of the lung, AIDS-related Dementia, Lung, Encephalopathies, Neoplasms, malignant lung tumor, lung cancer, Benign Neoplasm, Malignant, autosomal dominant, supernumerary, antibody, melanoma (disease), BCR complex, AIDS related Dementia Complex, HIV Encephalopathies, Dementia associated with AIDS, Pulmonary Cancer, immunoglobulin complex, HuCSADC, Dementia Complex, Pulmonary, HIV encephalitis, Drugs, Ly101, malignant tumour of the lung, Malignancy, Complex, Naevocarcinoma, LNCR, Cysteine sulfinic acid decarboxylase, inflammation, CD279, Neoplasias, drugs, Pdc1, Lung Neoplasm, malignant neoplasm of lung, CG7811, L17, HIV, Preparation, Pharmaceuticals, Cancer, Products, Pulmonary Neoplasms, Malignant Neoplasm, AIDS-related, malignant, drug, ADC - Acquired immune deficiency syndrome dementia complex, l17, DEMENTIA COMPLEX AIDS RELAT, Cell, HIV-1 Cognitive and Motor Complex, AIDS Encephalopathy, Melanomas, disease management., Malignant Melanoma, AIDS Dementia Complex, AIDS-related Dementia Complex, Neoplasm, malignant lung tumour, Nonsmall cell lung cancer, Glutamate decarboxylase-like protein 1, opsonin activity, DmelCG7811, malignant tumor of the lung, CSADC, Pharmaceutic Preparations, Pulmonary Neoplasm, increased number, 60S ribosomal protein L23, Cancers, odc-p, UFO, Ufo, T32F6.7, Drug, Aspartate 1-decarboxylase, present in greater numbers in organism, Preparations, nonsmall cell lung cancer, T32F6_7, Therapeutic, anon-34Db, AIDS related, HIV Dementia, B cell receptor activity, protection against, HIV associated cognitive and motor complex, malignant melanoma, Treatment, Pulmonary Cancers, Pharmaceutical Products, Neoplasia, Acquired immune deficiency syndrome-related dementia, Pharmaceutical PreparationfalseRNASeq of PDX and CDX tumours treated with ADCEnapotamab vedotin (EnaV), an antibody-drug conjugate (ADC) targeting AXL, effectively targets tumors that display insensitivity to immunotherapy and/or tumor-specific T cells in several melanoma and lung cancer models. Mechanistically, EnaV treatment induced an inflammatory response and immunogenic cell death in tumor cells, and promoted induction of a memory-like phenotype in cytotoxic T cells. Combining EnaV with tumor-specific T cells proved superior to any treatment alone in models of melanoma and lung cancer, and increased ICB benefit in models otherwise insensitive to anti-PD-1 treatment.2021-01-22 11:33:24EGAS000010045629606EGAD00001006620EGAC00001001826