EGAGenomicsCancer Genomicshttps://ega-archive.org/studies/EGAS00001004670EGAEGA study EGAS00001004670Copy number profiling of tissue and plasma samples from high grade serous epithelial ovarian cancer patientsEGArestrictedgrade 3/4, thymus nucleic acid, DNS, (Deoxyribonucleotide)n, DNAn+1, number, Double Stranded, Deoxyribonucleic acid, Double-Stranded, presence, free, high grade, Deoxyribonucleic acids, (Deoxyribonucleotide)n+m, count in organism, Client., Deoxyribonucleic Acid, Patient, Clients, cardinality, ds DNA, Desoxyribonukleinsaeure, malignant ovarian serous tumour, Double-Stranded DNA, (Deoxyribonucleotide)m, DNA, deoxyribonucleic acids, DNAn, ds-DNA, serous ovarian cancer, desoxyribose nucleic acidFresh, other disease, ZFYVE8, Antemortem Diagnosis, Fresh Frozen Plasma, determination, Effects, Blood, Neoplasms, Longterm., Benign Neoplasm, number, Ovarian Epithelial Cancer, Tumor, Diagnosis, Malignant, Ovarian Epithelial Carcinomas, presence, Long Term, Ovarian Epithelial Cancers, relapse, ovarian cancer, low depth, diseases, Ovarian, Mass, symptoms, disease or disorder, Screening, Hgr, diseases and disorders, Relapses, Antemortem, Effect, Epithelial, treatment, Fresh Frozen Plasmas, Fresh Frozen, Blood Plasma, human disease, Malignancy, Longterm, Recrudescences, Recurrences, Ovarian Cancer, Epithelial Cancer, Epithelial Carcinoma, Diagnoses and Examinations, Long-Term, Epithelial Ovarian Cancer, high grade, non-neoplastic, Neoplasias, Epithelial Ovarian, Ovarian Epithelial, Clients, Blood Plasmas, disease management, Therapies, disorder, Epithelial Ovarian Carcinoma, Homo sapiens disease, Malignancies, Long-Term Effect, shallow, Long-Term Effects, plasma, Diagnose, Cancer, Tumors, Therapy, Relapse, Antemortem Diagnoses, screening, Carcinoma, Frozen Plasma, findings, Hrs, HRS, Malignant Neoplasm, Ovarian Epithelial Carcinoma, disorders, Longterm Effect, medical condition, Plasmas, Client, Examination and Diagnoses, Diagnoses, Frozen Plasmas, count in organism, Postmortem, Screenings, Benign, Recrudescence, Mass Screenings, Examinations and Diagnoses, chemical analysis, Long Term Effects, Diseases, Neoplasm, condition, Epithelial Ovarian Carcinomas, Postmortem Diagnosis, Epithelial Ovarian Cancers, grade 3/4, Plasma, Diagnoses and Examination, Postmortem Diagnoses, follow up, ovarian epithelial cancer, signs, portion of plasma, Benign Neoplasms, Ovarian Carcinoma, patient, whole genome, Cancers, Treatments, Longterm Effects, Malignant Neoplasms, disease, Patient, Therapeutic, cardinality, Treatment, assay, other neoplasm, NeoplasiafalseCopy number profiling of circulating cell-free DNA from high grade serous ovarian cancer patientsIn order to find better markers of disease relapse and progression in high grade serous epithelial ovarian cancer (HGS-EOC) , we studied a cohort of 46 HGS-EOC patients with multiple plasma samples taken from diagnosis, throughout treatment and during follow up. We used shallow whole genome sequeincing (sWGS) with depths ranging from 0.5X to 1X to characterize the tumor fraction present in the samples, the copy number instability (CNI), and we sought to investigate whether the use of tumor fraction and the analysis of recurrent copy number alteration events would be a good measurement of the patient status over time.2020-12-21 13:06:18EGAS000010046709606EGAD00001006422EGAC00001001741