EGAGenomicsExome Sequencinghttps://ega-archive.org/studies/EGAS00001004735EGAEGA study EGAS00001004735Multi-region sequencing of 10 neuroblastoma casesMulti-region RNA-Seq data of 10 neuroblastoma casesMulti-region targeted Sequencing data of 10 neuroblastoma casesSNP Array CB1003restrictedEGApositional, WES, Complete Transcriptome, Complete, Complete Transcriptome Sequencing, Exome Sequencings, positional polypeptide feature, Complete Exome Sequencings, Neuroblastomas, region or site annotation, Complete Exome, Complete Exome Sequencing, Whole Transcriptome Sequencing, Neuroblastoma., Exome, primary structure of sequence macromolecule, Sequencing, geographical area, Exome Sequencing, Whole Exome, Whole, Whole Exome Sequencing, sequence, Whole Transcriptome, Transcriptome Sequencing, NB, Transcriptome SequencingsAntemortem Diagnosis, neuroblastoma, region or site annotation, Complete Exome, chemotherapy, Neoplasms, Central neuroblastoma, Benign Neoplasm, pharmacotherapy, Pharmacotherapies, Tumor, Malignant, Ximpact, Diagnosis, Chemotherapies, Relative, Mass, symptoms, Screening, Whole Transcriptome, Transcriptome Sequencing, Low, Antemortem, Separated, Drug Therapies, imprinted and ancient gene protein, positional, WES, Divorced, me75, Complete, Exome Sequencings, Malignancy, Complete Exome Sequencing, Whole Transcriptome Sequencing, Divorces, Diagnoses and Examinations, neuroblastoma (morphologic abnormality), D17Mit170, Sequencing, T1, [M]Neuroblastoma NOS (morphologic abnormality), Neoplasias, geographical area, Whole Exome, Whole, [M]Neuroblastoma NOS, heterogeneity, Therapies, Malignancies, NB - Neuroblastoma, Diagnose, Cancer, Tumors, Therapy, Antemortem Diagnoses, screening, Neuroblastoma (Schwannian Stroma-Poor), findings, Complete Exome Sequencings, Malignant Neoplasm, cou, Exome, Tl3, Tl2, Sympathicoblastoma, impact-a, Examination and Diagnoses, Diagnoses, Exome Sequencing, Lr, Benign, Postmortem, Screenings, Mass Screenings, Examinations and Diagnoses, Relative Risks, Neoplasm, sequence, Chemotherapies., imprinted and ancient gene protein homolog, IMPACT, Chemotherapy, NOS, NB, Postmortem Diagnosis, Relative Risk, Diagnoses and Examination, Separation, Complete Transcriptome, Postmortem Diagnoses, Complete Transcriptome Sequencing, positional polypeptide feature, Pharmacotherapy, Risk, Neuroblastomas, Neuroblastoma, Separations, Risks, signs, Benign Neoplasms, Cancers, primary structure of sequence macromolecule, Malignant Neoplasms, neuroblastoma NOS (morphologic abnormality), Drug, (Neuroblastoma NOS) or (sympathicoblastoma), Whole Exome Sequencing, Bra, pharmacologic therapy, other neoplasm, E430016J11Rik, Transcriptome Sequencings, Neoplasia, RWDD5falseMulti-region whole-exome sequencing of 10 neuroblastoma casesTo investigate intratumour heterogeneity and to better understand tumour evolution in neuroblastoma, we have performed a multi-region whole-exome sequencing on a total of 51 spatially separated tumor samples from 9 primary neuroblastomas (2 low-risk, 1 intermediate-risk and 6 high-risk) and 1 relapsed neuroblastoma. We also assessed the impact of chemotherapy on the clonal expansion by sequencing tumour regions from one medium risk and one high-risk tumour for which we had matched samples obtained at diagnosis and after chemotherapy.2021-10-14 12:39:48EGAS000010047359606EGAD00001008020EGAD00001008156EGAD00001008133EGAD00010002225EGAC00001001766