{"database":"EGA","file_versions":[],"scores":null,"additional":{"omics_type":["Genomics"],"study_type":["Cancer Genomics"],"full_dataset_link":["https://ega-archive.org/studies/EGAS00001004813"],"host":["EGA"],"description":["EGA study EGAS00001004813"],"dataset_title":["Dataset for gynecologic_cancer-EXON","Dataset for urologic_cancer-RNA","Dataset for liposarcoma-WHOLE_GENOME","Dataset for urologic_cancer-WHOLE_GENOME","Dataset of Master Samples submitted to other HIPO projects","Dataset for NSCLC-EXON","Dataset for gynecologic_cancer-RNA","Dataset for GIST-RNA","Dataset for hematopoietic_malignancy-WHOLE_GENOME","Dataset for upper_gastrointestinal_tumor-RNA","Dataset for NSCLC-WHOLE_GENOME","Dataset for Ewing_sarcoma_PNET-RNA","Dataset for other_cancer-WHOLE_GENOME","Dataset for hepatopancreaticobiliary_malignancy-WHOLE_GENOME","Dataset for NSCLC-RNA","Dataset for melanoma-RNA","Dataset for head_and_neck_cancer-EXON","Dataset for melanoma-WHOLE_GENOME","Dataset for synovial_sarcoma-WHOLE_GENOME","Dataset for neuroendocrine_adrenal_tumor-WHOLE_GENOME","Dataset for colorectal_cancer-RNA","Dataset for soft_tissue_tumor-RNA","Dataset for soft_tissue_tumor-EXON","Dataset for synovial_sarcoma-RNA","Dataset for soft_tissue_tumor-WHOLE_GENOME","Dataset for cancer_of_unknown_primary-EXON","Dataset for Ewing_sarcoma_PNET-EXON","Dataset for bone_cancer-RNA","Dataset for bone_cancer-WHOLE_GENOME","Dataset for GIST-EXON","Dataset for head_and_neck_cancer-RNA","Dataset for Ewing_sarcoma_PNET-WHOLE_GENOME","Dataset for GIST-WHOLE_GENOME","Dataset for neuroendocrine_adrenal_tumor-EXON","Dataset for liposarcoma-EXON","Dataset for neuroendocrine_adrenal_tumor-RNA","Dataset for hepatopancreaticobiliary_malignancy-RNA","Dataset for hematopoietic_malignancy-RNA","Dataset for colorectal_cancer-WHOLE_GENOME","Dataset for leiomyosarcoma-EXON","Dataset for other_cancer-RNA","Dataset for hematopoietic_malignancy-EXON","Dataset for breast_cancer-RNA","Dataset for cancer_of_unknown_primary-RNA","Dataset for upper_gastrointestinal_tumor-WHOLE_GENOME","Dataset for head_and_neck_cancer-WHOLE_GENOME","Dataset for hepatopancreaticobiliary_malignancy-EXON","Dataset for cancer_of_unknown_primary-WHOLE_GENOME","Dataset for upper_gastrointestinal_tumor-EXON","Dataset for urologic_cancer-EXON","Subset of EGAS00001004662 WGS data (2 tumor/control pairs) which are used in EGAS00001004813 (Titel: Comprehensive Genomic and Transcriptomic Analysis of Rare Cancers for Guiding of Therapy (H021))","Dataset for breast_cancer-WHOLE_GENOME","Dataset for other_cancer-EXON","Dataset for colorectal_cancer-EXON","Dataset for bone_cancer-EXON","Dataset for gynecologic_cancer-WHOLE_GENOME","Dataset for melanoma-EXON","Dataset for liposarcoma-RNA","Dataset for synovial_sarcoma-EXON","Dataset for breast_cancer-EXON","Dataset for leiomyosarcoma-RNA","Dataset for leiomyosarcoma-WHOLE_GENOME"],"repository":["EGA"],"category":["restricted"],"additional_accession":[]},"is_claimable":false,"name":"Comprehensive Genomic and Transcriptomic Analysis of Rare Cancers for Guiding of Therapy (H021)","description":"Here we analyzed the molecular profiles and clinical outcomes of 1,310 patients (proportion of rare cancers, 75%) enrolled in a prospective observational study by the German Cancer Consortium that applies whole-genome/exome and RNA sequencing to inform the care of adults with incurable cancers. Based on 472 single and six composite biomarkers, a cross-institutional molecular tumor board provided evidence-based management recommendations, including diagnostic reevaluation, genetic counseling, and experimental treatment, in 88% of cases. Recommended therapies were administered in 362 of 1,138 patients (31.8%) and resulted in significantly improved response and disease control rates (23.9% and 55.3%, respectively) compared to previous therapies, translating into a progression-free survival ratio >1.3 in 35.7% of patients.","dates":{"updated":"2022-09-08 11:17:51"},"accession":"EGAS00001004813","cross_references":{"TAXONOMY":["9606"],"EGA":["EGAD00001008888","EGAD00001008903","EGAD00001008862","EGAD00001008861","EGAD00001008877","EGAD00001008857","EGAD00001008866","EGAD00001008873","EGAD00001008880","EGAD00001008886","EGAD00001008850","EGAD00001008896","EGAD00001008883","EGAD00001008865","EGAD00001008879","EGAD00001008870","EGAD00001008890","EGAD00001008905","EGAD00001008847","EGAD00001008897","EGAD00001008901","EGAD00001008863","EGAD00001008867","EGAD00001008904","EGAD00001008856","EGAD00001008906","EGAD00001008860","EGAD00001008900","EGAD00001008899","EGAD00001008874","EGAD00001008882","EGAD00001008881","EGAD00001008871","EGAD00001008902","EGAD00001008878","EGAD00001008887","EGAD00001008848","EGAD00001008854","EGAD00001008858","EGAD00001008872","EGAD00001008869","EGAD00001008846","EGAD00001008855","EGAD00001008898","EGAD00001008876","EGAD00001008889","EGAD00001008884","EGAD00001008844","EGAD00001008845","EGAD00001008851","EGAD00001008885","EGAD00001008868","EGAD00001008852","EGAD00001008891","EGAD00001008892","EGAD00001008859","EGAD00001008853","EGAD00001008849","EGAD00001008895","EGAD00001008875","EGAD00001008893","EGAD00001008894","EGAC00001000452"]}}