EGAGenomicsCancer Genomicshttps://ega-archive.org/studies/EGAS00001004813EGAEGA study EGAS00001004813Dataset for gynecologic_cancer-EXONDataset for urologic_cancer-RNADataset for liposarcoma-WHOLE_GENOMEDataset for urologic_cancer-WHOLE_GENOMEDataset of Master Samples submitted to other HIPO projectsDataset for NSCLC-EXONDataset for gynecologic_cancer-RNADataset for GIST-RNADataset for hematopoietic_malignancy-WHOLE_GENOMEDataset for upper_gastrointestinal_tumor-RNADataset for NSCLC-WHOLE_GENOMEDataset for Ewing_sarcoma_PNET-RNADataset for other_cancer-WHOLE_GENOMEDataset for hepatopancreaticobiliary_malignancy-WHOLE_GENOMEDataset for NSCLC-RNADataset for melanoma-RNADataset for head_and_neck_cancer-EXONDataset for melanoma-WHOLE_GENOMEDataset for synovial_sarcoma-WHOLE_GENOMEDataset for neuroendocrine_adrenal_tumor-WHOLE_GENOMEDataset for colorectal_cancer-RNADataset for soft_tissue_tumor-RNADataset for soft_tissue_tumor-EXONDataset for synovial_sarcoma-RNADataset for soft_tissue_tumor-WHOLE_GENOMEDataset for cancer_of_unknown_primary-EXONDataset for Ewing_sarcoma_PNET-EXONDataset for bone_cancer-RNADataset for bone_cancer-WHOLE_GENOMEDataset for GIST-EXONDataset for head_and_neck_cancer-RNADataset for Ewing_sarcoma_PNET-WHOLE_GENOMEDataset for GIST-WHOLE_GENOMEDataset for neuroendocrine_adrenal_tumor-EXONDataset for liposarcoma-EXONDataset for neuroendocrine_adrenal_tumor-RNADataset for hepatopancreaticobiliary_malignancy-RNADataset for hematopoietic_malignancy-RNADataset for colorectal_cancer-WHOLE_GENOMEDataset for leiomyosarcoma-EXONDataset for other_cancer-RNADataset for hematopoietic_malignancy-EXONDataset for breast_cancer-RNADataset for cancer_of_unknown_primary-RNADataset for upper_gastrointestinal_tumor-WHOLE_GENOMEDataset for head_and_neck_cancer-WHOLE_GENOMEDataset for hepatopancreaticobiliary_malignancy-EXONDataset for cancer_of_unknown_primary-WHOLE_GENOMEDataset for upper_gastrointestinal_tumor-EXONDataset for urologic_cancer-EXONSubset of EGAS00001004662 WGS data (2 tumor/control pairs) which are used in EGAS00001004813 (Titel: Comprehensive Genomic and Transcriptomic Analysis of Rare Cancers for Guiding of Therapy (H021))Dataset for breast_cancer-WHOLE_GENOMEDataset for other_cancer-EXONDataset for colorectal_cancer-EXONDataset for bone_cancer-EXONDataset for gynecologic_cancer-WHOLE_GENOMEDataset for melanoma-EXONDataset for liposarcoma-RNADataset for synovial_sarcoma-EXONDataset for breast_cancer-EXONDataset for leiomyosarcoma-RNADataset for leiomyosarcoma-WHOLE_GENOMEEGArestrictedfalseComprehensive Genomic and Transcriptomic Analysis of Rare Cancers for Guiding of Therapy (H021)Here we analyzed the molecular profiles and clinical outcomes of 1,310 patients (proportion of rare cancers, 75%) enrolled in a prospective observational study by the German Cancer Consortium that applies whole-genome/exome and RNA sequencing to inform the care of adults with incurable cancers. Based on 472 single and six composite biomarkers, a cross-institutional molecular tumor board provided evidence-based management recommendations, including diagnostic reevaluation, genetic counseling, and experimental treatment, in 88% of cases. Recommended therapies were administered in 362 of 1,138 patients (31.8%) and resulted in significantly improved response and disease control rates (23.9% and 55.3%, respectively) compared to previous therapies, translating into a progression-free survival ratio >1.3 in 35.7% of patients.2022-09-08 11:17:51EGAS000010048139606EGAD00001008888EGAD00001008903EGAD00001008862EGAD00001008861EGAD00001008877EGAD00001008857EGAD00001008866EGAD00001008873EGAD00001008880EGAD00001008886EGAD00001008850EGAD00001008896EGAD00001008883EGAD00001008865EGAD00001008879EGAD00001008870EGAD00001008890EGAD00001008905EGAD00001008847EGAD00001008897EGAD00001008901EGAD00001008863EGAD00001008867EGAD00001008904EGAD00001008856EGAD00001008906EGAD00001008860EGAD00001008900EGAD00001008899EGAD00001008874EGAD00001008882EGAD00001008881EGAD00001008871EGAD00001008902EGAD00001008878EGAD00001008887EGAD00001008848EGAD00001008854EGAD00001008858EGAD00001008872EGAD00001008869EGAD00001008846EGAD00001008855EGAD00001008898EGAD00001008876EGAD00001008889EGAD00001008884EGAD00001008844EGAD00001008845EGAD00001008851EGAD00001008885EGAD00001008868EGAD00001008852EGAD00001008891EGAD00001008892EGAD00001008859EGAD00001008853EGAD00001008849EGAD00001008895EGAD00001008875EGAD00001008893EGAD00001008894EGAC00001000452