{"database":"EGA","file_versions":[],"scores":null,"additional":{"omics_type":["Genomics"],"study_type":["Epigenetics"],"full_dataset_link":["https://ega-archive.org/studies/EGAS00001004851"],"host":["EGA"],"description":["EGA study EGAS00001004851"],"dataset_title":["RRBS analysis to characterize the epigenomic conservation between species in the context of Aging and Cancer."],"repository":["EGA"],"category":["restricted"],"name_synonyms":["the brain, Senescence, primary cancer, suprasegmental structures, DNA methylation maintenance, Malignant Neoplasm, Malignancy, Neoplasms, Encephalon, Benign Neoplasm, Benign Neoplasms, DNA Methylations, Cancers, DNA methylation, Aging, suprasegmental levels of nervous system, Tumor, Malignant, encephalon, malignant tumor, Neoplasias, Biological Aging, MT, Benign, malignant neoplasm, Biological, Neoplasm, synganglion, Malignancies, DNA, Methylations, Methylation, Neoplasia, Cancer, Tumors, Malignant Neoplasms."],"description_synonyms":["projections, the brain, H2S(D2S), human being, experimental, determination, Laboratory, lamellae, Neoplasms, postnatal development, Mus domesticus, Benign Neoplasm, number, A4, l(2)02029, growth and development, DNA Methylations, Aging, Risk Factor Score, Tumor, Malignant, process of organ, House Mouse, presence, TYPE, CG11121, Human, Agent, DAGA4, lamella, Risk Factors, old, Homo sapiens, reduced, House, DmelCG11121, Biological, Mus musculus domesticus, synganglion, tiny, MAM, Mice, SCG3, Man, Risk Factor, Correlates, Vasp, average, Senescence, study, DmelCG15112, ENHANCER OF ATNSI ACTIVITY, methods, somda, reduced representation bisulfite-seq, Populations at Risk, DNA methylation maintenance, Man (Taxonomy), Malignancy, Swiss, experimental section, hypoplasia, Risk Score, bisulfite, Swiss Mice, ridges, DNA methylation, suprasegmental levels of nervous system, man, SO, Population at Risk, Epigenomic, Social, VASP, Neoplasias, Biological Aging, RRBS assay, Health Correlates, malignant neoplasm, papilla, MENA, Social Risk Factor, Malignancies, house mouse, associated, laminae, Methylations, HHT1, So, Cancer, Tumors, Drl, small, data, suprasegmental structures, Malignant Neoplasm, Edg, Data Set, hydrosulfite, Modern, lamina, mouse, flanges, Factor, Risk Factor Scores, encephalon, Patient Agent, Mdu, LGMD2C, development, Proxies, count in organism, MT, Benign, Mus, mda, chemical analysis, shelf, Neoplasm, Score, RRBS, Enb, ENA, Ena, END, flange, ami, organ process, Data Base, CG15112, ENA/VASP, Mus musculus, primary cancer, Factors, Social Risk Factors, Risk, DMDA1, underdeveloped, Epigenetic, mice, med, shelves, Encephalon, NDPP1, postnatal growth, Swiss Mouse, Benign Neoplasms, House Mice, Cancers, enb, projection, malignant tumor, ridge, cardinality., human, Risk Scores, Malignant Neoplasms, domesticus, Laboratory Mice, experimental procedures, processes, Social Risk, Health, DMDA, Agents, Patient, Modern Man, SCARMD2, Mouse, assay, DNA, Epigenetics, ORW1, growth, Laboratory Mouse, Neoplasia, Methylation"],"additional_accession":[]},"is_claimable":false,"name":"AGECAN - Interespecies conservation of brain specific DNA methylation in aging and cancer","description":"Aging is one of the main risk factors associated with the development of cancer. These two processes have been extensively investigated from the epigenetic perspective and consequently analogous epigenetic alterations have been identified for both, providing explanations on the possible molecular links between them. However, there is a need to study aging- and cancer-associated epigenetic patterns in a systematic manner to facilitate an integrated comparison between the two processes. In addition, it is essential to also confirm whether aging- and cancer-associated epigenetic alterations are equivalent in human and mouse models, as the latter are the main experimental proxy of human biology.In this study we sought to perform a systematic, integrated and intercomparable analysis of the DNA methylation dynamics associated to cancer and aging in both human and mouse. To this end, we profiled the brain methylomes of young and old, normal and tumoral brain samples from human and mouse by reduced-representation bisulfite sequencing (RRBS), which provided a robust and interspecies-comparable platform for these type of analyses. This data set only contains files involving human specimens. Accompanying mouse data can be downloaded from the ENA database under the accession number PRJEB41460.","dates":{"updated":"2021-03-22 12:55:25"},"accession":"EGAS00001004851","cross_references":{"TAXONOMY":["9606"],"EGA":["EGAD00001006650","EGAC00001001840"]}}