EGAGenomicsRNASeqhttps://ega-archive.org/studies/EGAS00001004987EGAEGA study EGAS00001004987Single cell sequencing of ovarian cancerEGArestrictedextent, Therapy, RNA, Ribonucleic, dTAF[[II]]230, TAF[[II]]250, d230, ribose nucleic acid, Stromal, completeness, neoplasia, Neoplasms, ribonucleic acids, TAF200, l(3)84Ab, RNA-seq, dTAFII250, RNS, neoplastic disease, BG:DS00004.13, TAFII-250, Tumor, TAF250/230, EfW1, Cell, tumours, NEOPL, dTAF230, dmTAF[[II]]230, TAFII250, neoplastic growth, dmTAF1, Taf230, p230, yeast nucleic acid, Stromal Cell, Ribonukleinsaeure, Gene Products, TAF[[II]]250/230, TFIID, pentosenucleic acids, Whole Transcriptome Shotgun Sequencing, Ribonucleic acids, neoplasm, Non Polyadenylated, RNA Gene Products, TAF250, Taf[[II]]250, treatment, ribonucleic acid, Acid, Taf200, dTAF[[II]]250, TAF[[II]]230, TFIID TAF250, cel, cell, cell process disease, tumor disease, Non Polyadenylated RNA, neoplasm (disease), Non-Polyadenylated, Taf1p, TAF[II]250, tumour, Ribonucleic Acid, Dietary Fiber, CG17603, TAF[[II]], disease of cellular proliferation, Treatments, Stromal Cell., Non-Polyadenylated RNA, dTAF250, MALIGNANT AND UNSPECIFIED (INCL CYSTS AND POLYPS), DmelCG17603, Taf250, Therapeutic, SR3-5, Cells, disease management, Therapies, Treatment, tumor, TAF, other neoplasm, NEOPLASMS BENIGN, Neoplastic Growth, Neoplasia, TAF230, TAF1, TumorsRNA, Ribonucleic, dTAF[[II]]230, TAF[[II]]250, d230, ribose nucleic acid, ribonucleic acids, TAF200, l(3)84Ab, dTAFII250, RNS, BG:DS00004.13, TAFII-250, TAF250/230, EfW1, Cell, dTAF230, dmTAF[[II]]230, TAFII250, dmTAF1, Taf230, p230, yeast nucleic acid, Ribonukleinsaeure, Gene Products, TAF[[II]]250/230, TFIID, pentosenucleic acids, Ribonucleic acids, Non Polyadenylated, TAF250, Taf[[II]]250, ribonucleic acid, Acid, Taf200, dTAF[[II]]250, TAF[[II]]230, TFIID TAF250, cel, cell, Non Polyadenylated RNA, Non-Polyadenylated, Taf1p, TAF[II]250, Ribonucleic Acid, CG17603, TAF[[II]], RNA Gene Products., Non-Polyadenylated RNA, dTAF250, DmelCG17603, Taf250, SR3-5, malignant ovarian serous tumour, serous ovarian cancer, TAF, TAF230, TAF1falseHigh-grade serous ovarian cancer refined with single-cell RNA-sequencingWe performed single-cell RNA-sequencing of 18,403 cells unbiasedly collected from 7 treatment-naive HGSOC tumours. For each phenotypic cluster of tumour or stromal cells, we identified specific transcriptomic markers. Next, we explored which phenotypic clusters correlate with overall survival based on expression of these transcriptomic markers in 1467 bulk RNA-seq tumours. By evaluating molecular subtype signatures in single cells, we assessed to what extent a phenotypic cluster of tumour or stromal cells contributes to each molecular subtype.2021-05-04 15:49:28EGAS000010049879606EGAD00001006898EGAC00001001928