EGAGenomicsOtherhttps://ega-archive.org/studies/EGAS00001005064EGAEGA study EGAS00001005064Mutational analysis of an oligoprogressive sarcomatoid hepatocellular carcinoma treated with an immune checkpoint inhibitor.EGArestrictedCarcinomas, antagonists, inhibitors, Carcinoma, Liver, Adult Liver Cancers, Hepatocellular carcinoma, determination, Liver Cancer, Hepatoma, adult primary hepatocellular carcinoma, Liver Cancers, inhibiteur, Cell Carcinoma, inhibitor, Liver Cell, Cancers, adult hepatoma, Adult, Hepatomas, antagonists and inhibitors., Liver Cell Carcinoma, Hepatocellular Carcinoma, Cell Carcinomas, inhibidor, HCC, Liver Cell Carcinomas, chemical analysis, Hepatocellular, Adult Liver Cancer, assay, Adult Liver, Hepatocellular Carcinomas, Cancerthe brain, Bones and Bone Tissue, ONO-4538, determination, Metastasis, BMS 936558, Neoplasms, Benign Neoplasm, Cell Carcinoma, BMS936558, Neoplasm Metastases, adult hepatoma, neoplasm metastasis, Tumor, Hepatomas, Malignant, Liver Cell Carcinoma, osteogenic tissue, cancer metastasis, protrusion, Cell Carcinomas, Bone and Bone, primary tumour, Liver Cell Carcinomas, Roles, Adult Liver Cancer, Concepts, synganglion, ONO 4538, Bone Tissues, study, tumor cell migration, Liver Cancer, Malignancy, Metastases., Tissues, MDX-1106, Tissue, adult primary hepatocellular carcinoma, Liver Cancers, inhibiteur, metastasis, Opdivo, Adult, suprasegmental levels of nervous system, Hepatocellular Carcinoma, genetic, Neoplasias, ONO4538, inhibidor, Clients, Role Concepts, Condyles, Malignancies, Apophysis, constitutitional genetic, Bony Apophyses, tumor metastasis, Cancer, Tumors, MDX1106, inhibitors, Carcinoma, Liver, suprasegmental structures, anatomical protrusion, Malignant Neoplasm, Apophyses, Metastases, familial, inhibitor, Liver Cell, Client, encephalon, Concept, Bones and Bone, Metastase, MDX 1106, Benign, Role Concept, HCC, chemical analysis, Neoplasm, Role, Adult Liver, bones, Carcinomas, antagonists, osseous tissue, Adult Liver Cancers, Hepatocellular carcinoma, Hepatoma, primary neoplasia, portion of bone tissue, Encephalon, Benign Neoplasms, patient, Cancers, Condyle, Bones, Malignant Neoplasms, metastatic, mineralized bone tissue, Bony, Patient, antagonists and inhibitors, Bone Tissue, primary tumor, bone, spine, BMS-936558, Hepatocellular, calcium tissue, inherited genetic, assay, Bony Apophysis, Hepatocellular Carcinomas, other neoplasm, bone organ, hereditary, Bone, NeoplasiafalseMutational analysis of an oligoprogressive sarcomatoid hepatocellular carcinoma treated with an immune checkpoint inhibitor.In this study, we describe a patient diagnosed with metastatic sarcomatoid hepatocellular carcinoma that showed a remarkable tumor response to Nivolumab, an immune checkpoint inhibitor, followed by an oligoprogression. Molecular analysis of the primary tumor in addition to a bone and brain metastasis was performed and we were able to identify driver genetic alterations indicating a possible role in the tumorigenesis process besides some alterations that may be associated with metastasis.2022-07-19 12:06:46EGAS000010050649606EGAD00001006982EGAC00001001976