{"database":"EGA","file_versions":[],"scores":null,"additional":{"omics_type":["Genomics"],"study_type":["Cancer Genomics"],"full_dataset_link":["https://ega-archive.org/studies/EGAS00001005109"],"host":["EGA"],"description":["EGA study EGAS00001005109"],"dataset_title":["Molecular profiling of tissue autopsies and ctDNA"],"repository":["EGA"],"category":["restricted"],"name_synonyms":["Neoplasias, primary cancer, MT, Benign, Malignant Neoplasm, malignant neoplasm, Malignancy, Neoplasms, Neoplasm, Benign Neoplasm, Malignancies, Benign Neoplasms, Cancers, Tumor, Malignant, malignant tumor, Neoplasia, Cancer, Tumors, Malignant Neoplasms."],"description_synonyms":["Cancer of the lung, primary breast cancer, Malignant tumor of lung, malignant tumor of the breast, Extrahepatic Cholangiocarcinoma, Lung, DNS, PhrB photolyase activity, (Deoxyribonucleotide)n, Neoplasms, malignant lung tumor, Intrahepatic Cholangiocarcinomas, lung cancer, Benign Neoplasm, mammary neoplasm, Mammary Cancers, malignant tumor of lung, Human Mammary Neoplasms, malignant neoplasm of the lung, Tumor, photoreactivating enzyme activity, pigmented epithelium, Malignant, Intrahepatic, autosomal dominant, Human, Mutations, Breast Malignant Tumor, Deoxyribonucleic Acid, \"neoplasm of breast (disorder)\" EXACT [SNOMEDCT_2005_07_31:126926005], Breast Tumor, \"mammary tumor\" EXACT [CSP2005:2016-0671], 3, breast tumor, stratum pigmentosa retinae, cancer of the breast, NUP96, Pulmonary Cancer, epithelium, Pulmonary cancer, Pulmonary, Cholangiocellular Carcinoma, BC, Mammary Neoplasms, malignant neoplasm of breast, Lung Cancer, Human Mammary, thymus nucleic acid, MOS3, malignant tumour of the lung, deoxyribocyclobutadipyrimidine pyrimidine-lyase activity, Malignancy, PRECOCIOUS, Mammary Neoplasm, alveolar cell carcinoma, Mammary Carcinoma, Extrahepatic, pigmented retina, Human Mammary Carcinomas, LNCR, F23A5.3, Double Stranded, Lung Cancers, Deoxyribonucleic acid, free, DNA cyclobutane dipyrimidine photolyase activity, Cancer of the Breast, SUPPRESSOR OF AUXIN RESISTANCE 3, genetic, Neoplasias, intrahepatic bile duct cancer (cholangiocarcinoma), Intrahepatic Cholangiocarcinoma, resistance to, Malignant neoplasm of lung, Lung Neoplasm, cancer of breast, Malignant Tumor of Breast, Mammary, Mammary Cancer, malignant neoplasm of lung, Clients, heterogeneity, Cholangiocarcinomas, Malignancies, Double-Stranded DNA, (Deoxyribonucleotide)m, deoxyribonucleic acids, DNAn, Breast, mammary cancer, constitutitional genetic, mammary tumor, Breast Malignant Neoplasms, F23A5_3, somatic mutation, Cancer, Tumors, PRE, Breast Carcinoma, Human Mammary Neoplasm, Carcinoma, Pulmonary Neoplasms, Lung cancer, Breast Carcinomas, Malignant Neoplasm, \"breast neoplasm\" EXACT [MTH:120], bile duct cancer, DNAn+1, deoxyribonucleic cyclobutane dipyrimidine photolyase activity, familial, Cancer of Lung, Double-Stranded, \"breast tumor\" EXACT [NCI2004_11_17:C2910], somatic, Cholangiocellular, Client, Breast Malignant Neoplasm, (Deoxyribonucleotide)n+m, MODIFIER OF SNC1, Benign, retinal pigment, Mammary Carcinomas, Cholangiocellular Carcinomas, cancer of lung, deoxyribonucleic photolyase activity, Neoplasm, malignant lung tumour, Nonsmall cell lung cancer, dipyrimidine photolyase (photosensitive), Human Mammary Carcinoma, NOS, Malignant lung tumor, malignant tumour of lung, ds-DNA, Extrahepatic Cholangiocarcinomas, desoxyribose nucleic acid, Malignant Neoplasm of Breast, retinal pigment layer, Carcinomas, Lung malignant tumors, malignant tumor of the lung, Breast Neoplasm, RPE, malignant lung neoplasm, photolyase activity, Pulmonary Neoplasm, Deoxyribonucleic acids., adenocarcinoma of lung, susceptibility to, Benign Neoplasms, Cancers, \"mammary neoplasm\" RELATED [], Cholangiocarcinoma, Malignant Neoplasms, p. pigmentosa retinae, response to tyrosine kinase inhibitor in, phr A photolyase activity, nonsmall cell lung cancer, DNA-photoreactivating enzyme, breast cancer, Patient, Breast Tumors, Breast Cancer, ds DNA, Breast Malignant Tumors, Desoxyribonukleinsaeure, protection against, Cancer of Breast, deoxyribonucleate pyrimidine dimer lyase (photosensitive), inherited genetic, Pulmonary Cancers, Cancer of the Lung, lung neoplasm, DNA, other neoplasm, hereditary, cancer, Neoplasia, breast"],"additional_accession":[]},"is_claimable":false,"name":"Sequencing of cancer autopsies and ctDNA","description":"Tumor heterogeneity is a major obstacle for precision oncology strategies. To characterize inter-lesion heterogeneity in pre-treated cancers, we performed genetic and transcriptomic profiling of synchronous lesions from ten rapid autopsies comprising six cases of breast cancer, three of cholangiocarcinoma and one lung cancer case.  For nine patients, we studied mutation representation in circulating cell-free DNA (cfDNA).","dates":{"updated":"2021-03-23 15:42:24"},"accession":"EGAS00001005109","cross_references":{"TAXONOMY":["9606"],"EGA":["EGAD00001007040","EGAC00001002015"]}}