{"database":"EGA","file_versions":[],"scores":null,"additional":{"omics_type":["Genomics"],"study_type":["Cancer Genomics"],"full_dataset_link":["https://ega-archive.org/studies/EGAS00001005389"],"host":["EGA"],"description":["EGA study EGAS00001005389"],"dataset_title":["Genomic Data for Integrative Profiling of T790M Negative EGFR Mutated NSCLC"],"repository":["EGA"],"category":["restricted"],"name_synonyms":["DER/faint little ball, Elp-B1RB1, Elp, D-Egf, Wa5, l(2)09261, TGF-alpha receptor activity, non-small cell lung carcinoma, ERBB, C-erb, dEGFR1, DEgfr, Elp-B1, der, Elp-1, mor1, Errb1, non-small cell carcinoma of the lung, mENA, EK2-6, CG10079, PIG61, non-small cell lung cancer, non-small cell cancer of the lung, torpedo/egfr, epidermal growth factor receptor activity, wa2, DmelCG10079, epidermal growth factor-activated receptor activity, AI552599, c-erbB, EGFr, Egfr, torpedo/Egfr, EGF receptor activity, TOP, Egf-r, NSCLC - non-small cell lung cancer, reaction., DER/top, Non-small cell lung cancer, d-egf-r, non-small cell lung carcinoma (disease), egfr, EGF-R, HD-33, El, top/DER, DER/EGFR, EGFR, EGfr, EgfR, dEgfr, DER flb, top, Torpedo/DER, ERBB1, wa-2, Torpedo/Egfr, flb, top/flb, Degfr, non-small cell carcinoma of lung, NSCLC, Egf, EFG-R, Errp, l(2)57EFa, Erbb, DEGFR, l(2)57DEFa, l(2)05351, Der, DER, 9030024J15Rik, D-EGFR, dEGFR, l(2)57Ea, transforming growth factor-alpha receptor activity, DmHD-33, non-small cell cancer of lung, DER/torpedo, HER1, NISBD2, DER1"],"description_synonyms":["DER/faint little ball, insensitive, determination, Adenomas, Feature, Elp-B1, der, Elp-1, Gene Expression Profile, Errb1, Profiles, Aging, sci, Technic, ADNOS, Tp53, PIG61, Techniques, diseases, Immunogold-Silver Techniques, Biological, epidermal growth factor-activated receptor activity, AI552599, Immunogold-Silver Technique, bbl, \"adenocarcinoma\" EXACT [NCI2004_11_17:C2852], Granular Cell Adenocarcinoma, HOW, How, diseases and disorders, Tubular Carcinoma, d-egf-r, l(3)j5D5, Cribriform Carcinoma, 24B, treatment, Senescence, human disease, Gene Expressions, BCC7, Adenoma, Granular Cell Carcinoma, stru, Tubular Carcinomas, PMNC, l(3)S053606, CG10293, Signatures, flb, l(3)j5B5, Biological Aging, Immunogold-Silver Technic, Expression Signature, Immunolabeling Technique, disease management, Transcriptomes, Therapies, 9030024J15Rik, s, D-EGFR, Homo sapiens disease, Immunogold Technics, NISBD2, DER1, Therapy, Carcinoma, 0904/17, Elp, Wa5, l(2)09261, DEgfr, Expression Profiles, Immunogold Technique, PMN cell, Adenocarcinomas, CG10079, predicted, Gene Expression, Immunogold, Immunogold Techniques, torpedo/egfr, Tubular, Immunolabeling Technic, wa2, Malignant Adenoma, SZ1, Expression Signatures, Diseases, Immunolabeling Technics, Technics, bfy, Expression Profile, Basal Cell Adenocarcinoma, Transcriptome Profiles, Carcinomas, egfr, HD-33, El, resistant, DER/EGFR, EGFR, EGfr, EgfR, \"adenocarcinoma\" EXACT [CSP2005:2000-0386], dEgfr, Cribriform, DER flb, Immunogold Silver Techniques, whole genome, Torpedo/Egfr, Features, Treatments, Tubular Adenocarcinomas, Degfr, loss of, disease, white blood cell, metastatic, Patient, DEGFR, l(2)57DEFa, l(2)05351, P53, p44, bhy, dEGFR, anon-EST:Liang-2.39, DmHD-33, polymorphonuclear cell, Adenocarcinoma, whole exome, other disease, Immunogold-Silver, D-Egf, Transcriptome Profile, C-erb, P62, p53, Oxyphilic Adenocarcinoma, mor1, Gene, mENA, EK2-6, Malignant, LFS1, Granular Cell Adenocarcinomas, Client., c-erbB, EGFr, Egfr, resistance, disease or disorder, torpedo/Egfr, EGF receptor activity, no subtype (morphologic abnormality)\" EXACT [SNOMEDCT_2005_07_31:35917007], TOP, Egf-r, Basal Cell Adenocarcinomas, Technique, Immunogold Silver Technics, EGF-R, l(3)s2612, Profile, Tubular Adenocarcinoma, top, Torpedo/DER, Cribriform Carcinomas, Expressions, top/flb, non-neoplastic, Trp53, Granular Cell Carcinomas, l(2)57EFa, Clients, DmelCG10293, disorder, l(2)57Ea, Expression, Characteristics, TRP53, Elp-B1RB1, Oxyphilic, Transcriptome, immune cell, Immunogold Technic, TGF-alpha receptor activity, Basal Cell, clone 2.39, ERBB, dEGFR1, disorders, Immunohistocytochemistry, medical condition, qkr, l(3)S090417, Client, Xp53, \"adenocarcinoma, Characteristic, epidermal growth factor receptor activity, DmelCG10079, KH93F, Gene Expression Signatures, chemical analysis, condition, Granular Cell, Gene Expression Signature, Oxyphilic Adenocarcinomas, DER/top, Immunolabeling, who, Immunocytochemistry, leucocyte, top/DER, ERBB1, Who/How, wa-2, \"adenocarcinomas\" EXACT [SNOMEDCT_2005_07_31:189578007], Malignant Adenomas, Egf, EFG-R, Therapeutic, Errp, Gene Expression Profiles, Erbb, Der, DER, Immunogold-Silver Technics, Immunolabeling Techniques, qkr[93F], Treatment, assay, transforming growth factor-alpha receptor activity, \"adenocarcinoma NOS (morphologic abnormality)\" EXACT [SNOMEDCT_2005_07_31:189582009], Signature, DER/torpedo, HER1"],"additional_accession":[]},"is_claimable":false,"name":"Integrative Profiling of T790M Negative EGFR Mutated NSCLC Reveals Pervasive Lineage Transition and Therapeutic Opportunities","description":"We performed whole exome and transcriptome analysis of 59 first- and second-generation EGFR TKI resistant metastatic EGFR mutated patients to characterize and compare molecular alterations mediating resistance in T790M positive and negative disease. Transcriptomic analysis revealed ubiquitous loss of adenocarcinoma lineage gene expression in T790M negative tumors, orthogonally validated using multiplex immunohistochemistry. There was enrichment of genomic features such as TP53 alterations, 3q chromosomal amplifications, whole genome doubling and non-aging mutational signatures in T790M negative tumors. Almost half of resistant tumors were further classified as Immunehot, with clinical outcomes conditional on immune cell infiltration state and T790M status. Finally, using a Bayesian statistical approach, we explored how T790M negative and positive disease might be predicted using comprehensive genomic and transcriptomic profiles of treatment-naïve patients.","dates":{"updated":"2023-04-25 15:36:03"},"accession":"EGAS00001005389","cross_references":{"TAXONOMY":["9606"],"EGA":["EGAD00001010272","EGAC00001003182"]}}