EGAGenomicsExome Sequencinghttps://ega-archive.org/studies/EGAS00001005764EGAEGA study EGAS00001005764Germline loss-of-function P2RY8 variants in SLEEGArestrictedfalseJEM 20211004ROur mission is to undertake ground breaking research, combining fundamental science and strong clinical interactions, to uncover the mechanism of disease of our patients, ultimately to provide a diagnosis and improved treatments. SLE is an autoimmune disease with a strong genetic component. Genome-wide association studies (GWAS) have revealed that multiple common variants confer genetic susceptibility to SLE, defining key pathways involved in disease pathogenesis.2021-11-16 13:33:21EGAS000010057649606EGAD00001008330EGAC00001002394