{"database":"EGA","file_versions":[],"scores":null,"additional":{"omics_type":["Genomics"],"study_type":["Cancer Genomics"],"full_dataset_link":["https://ega-archive.org/studies/EGAS00001005897"],"host":["EGA"],"description":["EGA study EGAS00001005897"],"dataset_title":["Multi-region sequencing of RCC with VTT and metastasis using WES and RNAseq"],"repository":["EGA"],"category":["restricted"],"name_synonyms":["DEFINE-ORIGINS, Origin Source, LOINC Axis 3, ORIGINS, CDISC Define-XML Origin Source Terminology, Advanced Renal Cell Carcinoma., Timing"],"description_synonyms":["Thrombus, Independent for Transfer Between Wheelchair and Bed., clear cell renal cell adenocarcinoma, Collecting Duct, RNA Sequence Determination, Product, determination, Metastasis, Sequence Determination, RNA Sequence, clinical data, Direct, Getting Up, adenocarcinoma of kidney, Neoplasm Metastases, Biochemical Pathway, ZDBF1, neoplasm metastasis, Tumor, Papillary Renal Cell Carcinoma, Vein, CCRCC, cancer metastasis, clot, Thromboses, Origin Source, Relative, vein, Adenocarcinoma Of Kidneys, Renal Cell Adenocarcinomas, primary tumour, diseases, Biological, RCC, diseases and disorders, Analysis, Biological Product, VEIN, Arising, independent, human disease, Hypernephromas, Biologic Drugs, Thinking Skill, Analyses, Determination, thrombus, Molecular, Natural, Pathways, Ask, Biological Drugs, ASK, Sequence Determinations, CHIF, clear cell renal cell carcinoma, geographical area, Biological Medicine, Independence, blood, Usually Need Help from Another Person for Arising, Critical Thinking, Medicine, LOINC Axis 3, Mekk5, Homo sapiens disease, Renal Collecting Duct Carcinoma, Malignancies, Medicines, Biologic Drug, blood clot, Tumors, Blood Clot, Carcinoma, Adenocarcinoma Of, Pathway, anatomical protrusion, Biologic Products, Blood Clots, Renal Cell Adenocarcinoma, Adenocarcinoma Of Kidney, Metabolic Network, Renal Cell Carcinoma, Adenocarcinomas, Determinations, Territory, Collecting Duct Carcinoma of the Kidney, Clear Cell Renal Cell Carcinoma, Benign, Representation, Biopharmaceuticals, Thought, Diseases, Biologic Product, Visible Lesion, State, Hypernephroma, Lesion, Clinical Data, Carcinomas, AA545217, kidney adenocarcinoma, positional polypeptide feature, Moving from wheelchair to bed and return independent, Representational, Biological Medicines, Kidney, Relative Value, Biological Drug, Contributory, Relation, Exomes, thrombosis, Benign Neoplasms, Biologics, Nephroid, State Ownership, Renal Cell Cancer, Genomic, Malignant Neoplasms, Papillary, disease, Multiple, ASK1, Patient, primary tumor, spine, Collecting Duct Carcinoma (Kidney), Atherothrombosis, Thoughts, renal cell carcinoma, ORIGINS, molecular pathway, other neoplasm, Nephroid Carcinoma, Contribute, Clear Cell Renal Carcinoma, Adenocarcinoma, other disease, whole exome, Clinical Batch, Thinking, Biologic Pharmaceuticals, Independent for Transfer, region or site annotation, Neoplasms, Renal Cell Cancers, Benign Neoplasm, Renal Adenocarcinomas, Malignant, blood Clots, protrusion, Hypernephroid, Sarcomatoid Renal Cell Carcinoma, disease or disorder, Hypernephroid Carcinomas, Renal Carcinomas, Hypernephroid Carcinoma, CDISC Define-XML Origin Source Terminology, hypernephroma, Timing, Grawitz Tumor, Biologicals, Drugs, tumor cell migration, positional, Clinical, Malignancy, Collecting Duct Carcinoma, DEFINE-ORIGINS, Natural Product, MAPKKK5, Renal, RELATIVE, metastasis, Sequencing, distant metastasis, non-neoplastic, Neoplasias, PERFORMED, RNA Sequence Analyses, Multi, Clients, genome, disorder, RNA Sequencing, TSULF, Collecting Duct Carcinomas (Kidney), Independent for Wheelchair Transfer, tumor metastasis, Biologic, Grawitz, Cancer, Sequence Analyses, Pharmaceuticals, Products, Perform, RNA, Malignant Neoplasm, Critical, RNA Sequence Determinations, Biologic Medicines, MULTIPLE, Chromophil Renal Cell Carcinoma, Collecting Duct Carcinomas, Metastases, disorders, Renal Cell Carcinomas, medical condition, Renal Adenocarcinoma, Client, Chromophobe Renal Cell Carcinoma, Metastase, US State, renal cell adenocarcinoma, Clinical Lot, distant cancer, chemical analysis, Biopharmaceutical, Neoplasm, sequence, condition, Distant Metastasis, clinical, Nephroid Carcinomas, UNQ630/PRO1246, lesion, Performed, Distant Cancer, Represent, 7420452D20Rik, Contributing, thrombotic disorder, DBF4A, primary neoplasia, Renal Cell, Renal Carcinoma, Directly, Thinking Skills, Cancers, primary structure of sequence macromolecule, Drug, GROSS LESION, Clots, Usually Need Help from Another Person for Getting Up, Collecting Duct (Kidney), Venous, RNA Sequence Analysis, Natural Products, Independent, assay, Representative, Neoplasia, Genome, Contribution"],"additional_accession":[]},"is_claimable":false,"name":"Origins and timing of emerging lesions in advanced renal cell carcinoma","description":"Renal cell carcinoma (RCC) with venous tumor thrombus (VTT) arising from the primary tumor occurs in ~10% of cases and is thought to represent more advanced disease.  RCC with VTT and distant metastasis provides unique opportunities to examine the origins and relative timing of tumor lesion emergence and to identify molecular correlates with disease state.  We performed multi-region exome and RNA sequencing analysis of a clinical cohort of 16 RCC patients with VTT, with eight patients also having sequenced metastasis, to examine which genomic alterations, biological pathways, and evolutionary processes contribute to VTT and metastasis, and to ask whether metastasis typically arises directly from VTT or is independent of VTT.","dates":{"updated":"2022-03-03 15:59:48"},"accession":"EGAS00001005897","cross_references":{"TAXONOMY":["9606"],"EGA":["EGAD00001008441","EGAC00001002463"]}}