{"database":"EGA","file_versions":[],"scores":null,"additional":{"omics_type":["Genomics"],"study_type":["Cancer Genomics"],"full_dataset_link":["https://ega-archive.org/studies/EGAS00001005992"],"host":["EGA"],"description":["EGA study EGAS00001005992"],"dataset_title":["Cell-free DNA and bone marrow samples from myelodysplastic syndromes"],"repository":["EGA"],"category":["restricted"],"name_synonyms":["Myelodysplastic Syndrome, dTAF[[II]]230, TAF[[II]]250, d230, DNS, (Deoxyribonucleotide)n, Myelodysplasia, DNAn+1, TAF200, l(3)84Ab, dTAFII250, BG:DS00004.13, Double-Stranded, TAFII-250, TAF250/230, EfW1, Cell, Deoxyribonucleic acids, Hematopoetic, dTAF230, (Deoxyribonucleotide)n+m, dmTAF[[II]]230, Hematopoetic Myelodysplasia, TAFII250, Deoxyribonucleic Acid, medulla ossium, dmTAF1, Taf230, p230, Marrow, medulla ossea, TAF[[II]]250/230, Dysmyelopoietic Syndromes, TFIID, Yellow, ds-DNA, desoxyribose nucleic acid, TAF250, Taf[[II]]250, Yellow Marrow, Taf200, thymus nucleic acid, dTAF[[II]]250, TAF[[II]]230, Hematopoetic Myelodysplasias, TFIID TAF250, Dysmyelopoietic Syndrome, cel, cell, medullary bone, medulla of bone, Double Stranded, Taf1p, TAF[II]250, Deoxyribonucleic acid, CG17603, TAF[[II]], free, Myelodysplastic, Red Marrow, Myelodysplastic Syndromes, dTAF250, DmelCG17603, Syndromes, Taf250, Myelodysplasias, SR3-5, ds DNA, Syndrome, Desoxyribonukleinsaeure, Red, Double-Stranded DNA, (Deoxyribonucleotide)m, DNA, deoxyribonucleic acids, DNAn, TAF, Bone, myelodysplastic syndrome, TAF230, susceptibility to., TAF1, Dysmyelopoietic"],"description_synonyms":["Mds1-Evi1, Dmel_CG31829, Nucleotide Sequencing, determination, Massively-Parallel, Characterization, Jbo, cfDNA, Circulating, dCul3, Circulating DNA, allele frequency, Compared, High-Throughput RNA Sequencing, sequencing assay, monitoring, medulla ossea, Correlated, Cell-Free, Mds1, correlation, Cell-Free Nucleic Acid, SF3b155, Cell Free Nucleic Acid, Detection, Deep Sequencing, DMcul-3, Correlation, thymus nucleic acid, cirDNA, Illumina Sequencing, Molecular, Comparison, LIS1, Massively Parallel DNA Sequencing, PAFAHA, paired, LIS2, Red Marrow, MDCR, High Throughput RNA Sequencing, Had, sample, lis2, Red, Allele, Double-Stranded DNA, mdcr, deoxyribonucleic acids, DNAn, Has, myelodysplastic syndrome, High-Throughput RNA, l(2)06430, pafah1b1-b, sequencing_assay, assessment, High-Throughput DNA Sequencing, CUL-3, Double-Stranded, DETECTION, results, gft/dCul-3, br34, Cell Free Ribonucleic Acid, (Deoxyribonucleotide)n+m, allele_frequency, Ion Torrent Sequencing, Massively-Parallel Sequencing, Next-Generation, NOS, Circulating Nucleic Acids, Ion Torrent, Cell-Free Deoxyribonucleic Acid, Assessed, desoxyribose nucleic acid, PRPF10, Acid, l35Cd, DmelCG42616, cul-3, Circulating Cell Free Nucleic Acids, Nucleic Acid Sequencing, medulla of bone, Biological Detection Test, Cell Free Nucleic Acids, Supported, Nucleic Acids, susceptibility to, Cullin3, SAP155, CG11861, platelet-activating factor acetylhydrolase IB subunit alpha, High Throughput Sequencing, Characterized, Znfpr1b1, Patient, 14-3-3E, Chromosome, monitor, ds DNA, Assess, CHROMOSOME, Supportive, Acids, DNA, Detected, VAF, Bone, Sequence Analysis, HEL2, Allelomorphs, Support, High Throughput DNA Sequencing, DNS, Cell-Free Deoxyribonucleic, (Deoxyribonucleotide)n, Circulating Cell Free Nucleic Acid, BOPS, Correlative, High-Throughput DNA, cul3, Compare, Cullin 3, Illumina, l(2)br34, Next-Generation Sequencing, Deoxyribonucleic acids, NEXT GENERATION SEQUENCING, Circulating Cell-Free Nucleic Acid, SEQUENCING, Biopolymer Sequencing, Client., Deoxyribonucleic Acid, pafah, Deep, Cell-Free RNA, Marrow, Molecular Fingerprint, CG31829, Yellow, Massively Parallel Sequencing, Cell Free DNA, Variant Allele Frequency, Cell Free Deoxyribonucleic Acid, CUL3, Ion Proton Sequencing, Profile, guftagu, Double Stranded, Deoxyribonucleic acid, Pyrosequencing, Evi1, D630039M04Rik, Cell-Free Ribonucleic, Sequencing, Circulating Cell-Free Nucleic Acids, Monitoring, Evi-1, Myelodysplastic Syndromes, Allelomorph, Next Generational Sequencing, Clients, Molecular Signature, High-Throughput, RNA Sequencing, gft, (Deoxyribonucleotide)m, Cul3, Possess, Molecular Profile, RNA, Molecular Biology, DNAn+1, KIAA1546, Client, MDS, Mds, Chromosomal, PRP10, Circulating RNA, medulla ossium, Have, Circulating Nucleic Acid, Nucleic Acid, DNA Sequencing, KCIP-1, chemical analysis, Hsh155, ds-DNA, Cell Free RNA, NGS, mds, Next Generation Sequencing, Cell-Free DNA, Yellow Marrow, Assessment, medullary bone, BG:DS07851.2, cirRNA, dCul-3, Ribonucleic Acid, PAFAH, sample population, NUCLEIC ACID SEQUENCING, cfRNA, CG42616, Circulating Nucleic, chromosome, High-Throughput Sequencing, Cell-Free Ribonucleic Acid, Supporting, Dmel_CG11861, Desoxyribonukleinsaeure, l(2)35Cd, High Throughput Nucleotide Sequencing, Prdm3, assay, Strategy, Ion Proton, High-Throughput Nucleotide"],"additional_accession":[]},"is_claimable":false,"name":"Cell-free DNA and bone marrow samples from myelodysplastic syndromes","description":"We have assessed the molecular profile of a cohort of 70 patients with MDS by next-generation sequencing (NGS) using cfDNA and compared the results to paired bone marrow (BM) DNA. Sequencing of BM DNA and cfDNA showed a comparable mutational profile and variant allele frequencies (VAF) strongly correlated between both sample types. Our results support the analysis of cfDNA as a promising strategy for performing molecular characterization, detection of chromosomal aberrations and monitoring of MDS patients.","dates":{"updated":"2022-02-16 18:49:03"},"accession":"EGAS00001005992","cross_references":{"TAXONOMY":["9606"],"EGA":["EGAD00001008567","EGAC00001002512"]}}