{"database":"EGA","file_versions":[],"scores":null,"additional":{"omics_type":["Genomics"],"study_type":["Exome Sequencing"],"full_dataset_link":["https://ega-archive.org/studies/EGAS00001006158"],"host":["EGA"],"description":["EGA study EGAS00001006158"],"dataset_title":["Whole exome sequencing of sequential samples from a CLL patient over the course of venetoclax treatment, BCR inhibitor treatment, and venetoclax re-treatment"],"repository":["EGA"],"category":["restricted"],"name_synonyms":["leukemia, CLL, Cll, 4-dimethyl-1-cyclohexen-1-yl)methyl)-1-piperazinyl)-n-((3-nitro-4-(((tetrahydro-2h-pyran-4-yl)methyl)amino)phenyl)sulfonyl)-2-(1h-pyrrolo(2, ABT-199., Complete Exome Sequencings, Complete Exome, Exome, Chronic Lymphocytic Leukemia, chronic LYMPHOCYTIC, lymphoplasmacytic leukaemia, 311, 4-dimethylcyclohex-1-en-1-yl)methyl)piperazin-1-yl)-N-((3-nitro-4-((tetrahydro-2H-pyran-4-ylmethyl)amino)phenyl)sulfonyl)-2-(1H-pyrrolo(2, 3-b)pyridin-5-yloxy)benzamide, lymphoplasmacytic leukemia, chronic, B-cell chronic lymphocytic leukaemia, benzamide, cll, CML, Exome Sequencing, 93Bal, B-cell chronic lymphoid leukemia, Whole Transcriptome, Transcriptome Sequencing, chronic lymphatic leukemia, lymphocytic, RG7601, chronic lymphatic, small lymphocytic lymphoma, RG-7601, WES, Complete Transcriptome, Complete, c15, Complete Transcriptome Sequencing, Exome Sequencings, GDC-0199, B-cell chronic lymphocytic leukemia, Complete Exome Sequencing, DmelCG7937, Whole Transcriptome Sequencing, 4-(4-((2-(4-chlorophenyl)-4, 3-b)pyridin-5-yloxy)-, Venclexta, adult chronic leukaemia, Sequencing, Ect5, Whole Exome, Hox11-311, Whole, Whole Exome Sequencing, adult chronic leukemia, chronic lymphocytic leukaemia, chronic lymphatic leukaemia, Transcriptome Sequencings, CG7937"],"description_synonyms":["DNA (cytosine-5)-methyltransferase 1, ALL, Dmel_CG00000, inhibitors, AT1G11140, 4-dimethyl-1-cyclohexen-1-yl)methyl)-1-piperazinyl)-n-((3-nitro-4-(((tetrahydro-2h-pyran-4-yl)methyl)amino)phenyl)sulfonyl)-2-(1h-pyrrolo(2, HSN1E, 5133400C09Rik, DNMT, familial, number, STRUBBELIG, inhibitor, 4-dimethylcyclohex-1-en-1-yl)methyl)piperazin-1-yl)-N-((3-nitro-4-((tetrahydro-2H-pyran-4-ylmethyl)amino)phenyl)sulfonyl)-2-(1H-pyrrolo(2, MCMT, 3-b)pyridin-5-yloxy)benzamide, presence, benzamide, Mutations, SUB, STRUBBELIG-RECEPTOR FAMILY 9, D22S662, CML, Aim, count in organism, AIM, CG17617, DmelCG12298, sensitive, DNA methyltransferase HsaI, CG40453, BCR, rhoGAP1A, CG40494, SCRAMBLED, RG7601, sensitivity, KIF20A, CG12298., AI561783, BCR1, DmelCG40494, CXXC9, antagonists, DNMT1, study, ADCADN, RG-7601, GDC-0199, UNQ203/PRO229, CT-2, DNMT1_HUMAN, D22S11, DNA (cytosine-5-)-methyltransferase 1, mei-1794, Dub, Specificity, inhibiteur, 4-(4-((2-(4-chlorophenyl)-4, PHL, EG:23E12.5, 3-b)pyridin-5-yloxy)-, Venclexta, CXXC-type zinc finger protein 9, CG17960, EG:23E12.2, ABT-199, genetic, allergic reaction, API6, AI853148, inhibidor, Specificity and Sensitivity, antagonists and inhibitors, cardinality, Sensitivity, inherited genetic, SRF9, mKIAA3017, constitutitional genetic, CXXC finger protein 9, hereditary, T19D16.8, CLEC2C, SCM, m.HsaI, DNA MTase HsaI"],"additional_accession":[]},"is_claimable":false,"name":"Exome sequencing in CLL re-treated with venetoclax","description":"The aim of this study was to identify mutational and genetic drivers of sensitivity and resistance to venetoclax and BCR inhibitors. Sequential samples were used to track the variant allele frequencies of driver mutations and copy number alterations. These were used to infer sub-clonal architecture through sequential therapies.","dates":{"updated":"2022-06-13 17:15:34"},"accession":"EGAS00001006158","cross_references":{"TAXONOMY":["9606"],"EGA":["EGAD00001008685","EGAC00001002616"]}}