EGAGenomicsExome Sequencinghttps://ega-archive.org/studies/EGAS00001006158EGAEGA study EGAS00001006158Whole exome sequencing of sequential samples from a CLL patient over the course of venetoclax treatment, BCR inhibitor treatment, and venetoclax re-treatmentEGArestrictedfalseExome sequencing in CLL re-treated with venetoclaxThe aim of this study was to identify mutational and genetic drivers of sensitivity and resistance to venetoclax and BCR inhibitors. Sequential samples were used to track the variant allele frequencies of driver mutations and copy number alterations. These were used to infer sub-clonal architecture through sequential therapies.2022-06-13 17:15:34EGAS000010061589606EGAD00001008685EGAC00001002616