EGAGenomicsOtherhttps://ega-archive.org/studies/EGAS00001006285EGAEGA study EGAS00001006285whole genome sequencing of breast cancer cell lines and patient derived xenograft modelsEGArestrictedXenograft, Complete, Xenotransplantation, Whole Genome, Transplantation, Heterograft, Complete Genome Sequencing, Genome Sequencing, Cell Lines, Heterografts, HETEROL TRANSPL, patient, Xenografts, TRANSPL HETEROL, Transplantations, Client, Sequencing, Cell, Complete Genome, XENOTRANSPL, Xenotransplantations, heterologous transplantation., Patient, Clients, Whole, Line, xenotransplant, Heterologous Transplantations, Heterologous, Linesprimary breast cancer, whole exome, malignant tumor of the breast, Materials, Activity, Laboratory, Heterograft, Neoplasms, mammary neoplasm, Mammary Cancers, Gene, Human Mammary Neoplasms, TRANSPL HETEROL, Tumor, Transplantations, heterologous transplantation, Human, Breast Malignant Tumor, low depth, "neoplasm of breast (disorder)" EXACT [SNOMEDCT_2005_07_31:126926005], Breast Tumor, "mammary tumor" EXACT [CSP2005:2016-0671], breast tumor, cancer of the breast, Research Activity, Laboratory Research, mammary carcinoma cell, mammary adenocarcinoma cell, Priorities, BC, Mammary Neoplasms, malignant neoplasm of breast, Human Mammary, Complete, Whole Genome, Genetic, Genomes, Research, Mammary Neoplasm, Mammary Carcinoma, Complete Genome Sequencing, breast epithelial cancer cell, Human Mammary Carcinomas, Heterografts, breast carcinoma cell, breast adenocarcinoma cell, Sequencing, Cancer of the Breast, Xenotransplantations, cancer of breast, Malignant Tumor of Breast, Clients, Mammary, Mammary Cancer, Whole, mammary tumor cell, Development and Research, Research Priority, Breast, mammary cancer, mammary tumor, shallow, Breast Malignant Neoplasms, Heterologous, Tumors, Cancer, WGS, Breast Carcinoma, Human Mammary Neoplasm, Carcinoma, Breast Carcinomas, "breast neoplasm" EXACT [MTH:120], average., incomplete, Genome Sequencing, Research Priorities, mammary gland carcinoma cell, "breast tumor" EXACT [NCI2004_11_17:C2910], Cistrons, Client, Breast Malignant Neoplasm, abolished, Priority, XENOTRANSPL, Complete Genome, Mammary Carcinomas, Research Activities, Neoplasm, Human Mammary Carcinoma, Genetic Materials, NOS, Malignant Neoplasm of Breast, Heterologous Transplantations, Genetic Material, Carcinomas, Research and Development, Xenograft, Breast Neoplasm, Xenotransplantation, Transplantation, mammary cancer cell, HETEROL TRANSPL, patient, INSDC_feature:gene, Xenografts, Cancers, whole genome, "mammary neoplasm" RELATED [], Activities, breast tumor cell, Patient, breast cancer, Material, Breast Tumors, Breast Cancer, Breast Malignant Tumors, Cancer of Breast, Cistron, cancer, breastfalseDeep whole genome sequencing identifies recurrent genomic alterations in breast cancer cell lines and patient derived xenograft modelsBreast cancer cell lines (BCCLs) and patient-derived xenografts (PDX) are the most frequently used models in breast cancer research. Despite their widespread usage, genome sequencing of these models is incomplete, with previous studies only focusing on targeted gene panels, whole exome or shallow whole genome sequencing. Here we describe deep whole genome sequencing (WGS) of commonly used BCCL and PDX models using the Illumina X10 platform with an average ~ 60x coverage.2022-06-02 10:30:11EGAS000010062859606EGAD00001008802EGAC00001002691