EGAGenomicsOtherhttps://ega-archive.org/studies/EGAS00001006410EGAEGA study EGAS00001006410PAMELA - 142 patients with HER2+ breast cancerRNA-seqrestrictedEGAErbb-2, 2-(4-(1, primary breast cancer, malignant tumor of the breast, ICI46474., RNA Sequence Determination, Sequence Determination, Neoplasms, RNA Sequence, tamoxifene, 474, 2-Diphenyl-1-butenyl)phenoxy)-N, mammary neoplasm, Apo-Tamox, Mammary Cancers, Human Mammary Neoplasms, ICI46, Femara, Tomaxithen, Tumor, tamoxifen, Human, CD340, Novaldex, Breast Malignant Tumor, CGS20267, 1-para-beta-Dimethylaminoethoxyphenyl-trans-1, Kiaa3023, ICI 47699, RRG6, Crisafeno, "neoplasm of breast (disorder)" EXACT [SNOMEDCT_2005_07_31:126926005], Breast Tumor, Benzonitrile, "mammary tumor" EXACT [CSP2005:2016-0671], 2, breast tumor, cancer of the breast, 4, CGS-20267, Analysis, 2-diphenyl-1-butenyl)phenoxy)-N, HER-2/neu, BC, Mammary Neoplasms, malignant neoplasm of breast, Human Mammary, tamoxifenum, Analyses, Determination, Mammary Neoplasm, ICI-47699, HER-2, Ethanamine, Mammary Carcinoma, 2-diphenylbut-1-ene, Tamoxifen Citrate, Human Mammary Carcinomas, trans-Tamoxifen, Sequence Determinations, Sequencing, Cancer of the Breast, (Z)-2-(4-(1, GEP6, tamoxifeno, RNA Sequence Analyses, cancer of breast, Malignant Tumor of Breast, Clients, Mammary, Mammary Cancer, Tamoxifen, RNA Sequencing, Breast, mammary cancer, mammary tumor, Breast Malignant Neoplasms, Sequence Analyses, Neu, NEU, Tumors, Cancer, Breast Carcinoma, Human Mammary Neoplasm, Carcinoma, RNA, N-dimethylethanamine, Breast Carcinomas, "breast neoplasm" EXACT [MTH:120], Citrate, RNA Sequence Determinations, 4'-(1H-1, HER-2|neu, mKIAA3023, 4-triazol-1-yl-methylene)-bis(benzonitrile), MLN19, "breast tumor" EXACT [NCI2004_11_17:C2910], ICI47699, Client, Determinations, Breast Malignant Neoplasm, 1-p-beta-Dimethylaminoethoxyphenyl-trans-1, Nolvadex, N-dimethyl-, Soltamox, ICI-46474, Mammary Carcinomas, Diemon, Neoplasm, ICI 46, NGL, Human Mammary Carcinoma, NOS, Malignant Neoplasm of Breast, c-neu, Carcinomas, ICI-46, Breast Neoplasm, (Z)-, c-erbB2, N-dimethylamine, Cancers, "mammary neoplasm" RELATED [], 4-triazol-1-ylmethylene)bis-, Fémara, (Z)-2-(para-(1, MLN 19, Zitazonium, Patient, breast cancer, RNA Sequence Analysis, Breast Tumors, Breast Cancer, Breast Malignant Tumors, TKR1, Cancer of Breast, ICI 46474, CGS 20267, cancer, HER2, breastErbb-2, 2-(4-(1, malignant tumor of the breast, Breasts, Activity, PhrB photolyase activity, Laboratory, tamoxifene, 474, 2-Diphenyl-1-butenyl)phenoxy)-N, mammary neoplasm, Lactiferous gland, Apo-Tamox, Human Mammary Neoplasms, Tomaxithen, Tumor, pigmented epithelium, glandula mammaria, GW282974X, tamoxifen, CD340, School-Age, CGS20267, 1-para-beta-Dimethylaminoethoxyphenyl-trans-1, Kiaa3023, diseases, Crisafeno, "neoplasm of breast (disorder)" EXACT [SNOMEDCT_2005_07_31:126926005], 2, diseases and disorders, 3, cancer of the breast, 4, GW572016, NUP96, Polymerase Chain, 2-diphenyl-1-butenyl)phenoxy)-N, Research Activity, Laboratory Research, epithelium, Priorities, BC, treatment, Mammary Neoplasms, malignant neoplasm of breast, Trastuzumab beta, human disease, tamoxifenum, N-(3-chloro-4-((3-fluorophenyl)methoxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)-2-furanyl)-4-quinazolinamine, Hormone Receptor, Ethanamine, Tamoxifen Citrate, Human Mammary Carcinomas, pigmented retina, Inverse Polymerase Chain Reaction, trans-Tamoxifen, DNA cyclobutane dipyrimidine photolyase activity, endocrine, (Z)-2-(4-(1, SUPPRESSOR OF AUXIN RESISTANCE 3, tamoxifeno, cancer of breast, Reaction, Tamoxifen, disease management, Therapies, Homo sapiens disease, stage, Research Priority, mammary cancer, Breast Malignant Neoplasms, Tumors, mamma, Therapy, PRE, Carcinoma, N-dimethylethanamine, Anchored Polymerase Chain Reaction, GW-282974X, "breast neoplasm" EXACT [MTH:120], Citrate, GW-572016, deoxyribonucleic cyclobutane dipyrimidine photolyase activity, Herceptin, Research Priorities, MLN19, Receptor Agonists, GW 282974X, Trazimera, 1-p-beta-Dimethylaminoethoxyphenyl-trans-1, Nolvadex, N-dimethyl-, Soltamox, retinal pigment, Lapatinib Ditosylate, Diemon, School Age, Lobe of mammary gland, Diseases, dipyrimidine photolyase (photosensitive), NOS, Malignant Neoplasm of Breast, retinal pigment layer, c-neu, PCR, Research and Development, Carcinomas, ICI-46, Populations, Nested Polymerase Chain Reaction, "mammary neoplasm" RELATED [], Treatments, 4-triazol-1-ylmethylene)bis-, polymerase chain reaction, Fémara, (Z)-2-(para-(1, Activities, MLN 19, disease, Zitazonium, phr A photolyase activity, DNA-photoreactivating enzyme, breast cancer, Patient, label, Breast Tumors, Breast Malignant Tumors, TKR1, School-Age Population, cancer, mammary region, primary breast cancer, other disease, Neoplasms, developmental stage, N-{3-CHLORO-4-[(3-FLUOROBENZYL)OXY]PHENYL}-6-[5-({[2-(METHYLSULFONYL)ETHYL]AMINO}METHYL)-2-FURYL]-4-QUINAZOLINAMINE, Mammary Cancers, ICI46, Polymerase Chain Reactions, Femara, photoreactivating enzyme activity, Inverse, Tykerb, Human, Hormone, Novaldex, Breast Malignant Tumor, Inverse PCR, ICI 47699, RRG6, Breast Tumor, Benzonitrile, disease or disorder, "mammary tumor" EXACT [CSP2005:2016-0671], breast tumor, stratum pigmentosa retinae, CGS-20267, HER-2/neu, Agonists, study, School-Age Populations, Human Mammary, hormones, MOS3, deoxyribocyclobutadipyrimidine pyrimidine-lyase activity, PRECOCIOUS, Research, Mammary Neoplasm, ICI-47699, HER-2, Mammary Carcinoma, 2-diphenylbut-1-ene, mammary part of chest, F23A5.3, Hormone Receptor Agonists, Population, Cancer of the Breast, non-neoplastic, GW 572016, GEP6, Malignant Tumor of Breast, Mammary, Mammary Cancer, Clients, disorder, Development and Research, Anchored PCR, School Age Population, Breast, N-(3-chloro-4-(((3-fluorobenzyl)oxy)phenyl)-6-(5-(((2-methylsulfonyl)ethyl)amino)methyl) -2-furyl)-4-quinazolinamine, mammary tumor, F23A5_3, Neu, NEU, Cancer, Breast Carcinoma, Human Mammary Neoplasm, Breast Carcinomas, 4'-(1H-1, HER-2|neu, Trastuzumab qyyp, mKIAA3023, disorders, 4-triazol-1-yl-methylene)-bis(benzonitrile), medical condition, "breast tumor" EXACT [NCI2004_11_17:C2910], Brustdruese, ICI47699, Client, Breast Malignant Neoplasm, MODIFIER OF SNC1, Priority, ICI-46474, Mammary Carcinomas, Research Activities, deoxyribonucleic photolyase activity, Neoplasm, ICI 46, NGL, Human Mammary Carcinoma, condition, Trastuzumab, ICI46474, School Age Populations., Anchored, Breast Neoplasm, (Z)-, RPE, Reactions, Nested, photolyase activity, c-erbB2, N-dimethylamine, Lobe of breast, Cancers, beta, p. pigmentosa retinae, Trastuzumab-qyyp, Therapeutic, Breast Cancer, Nested PCR, Cancer of Breast, Treatment, ICI 46474, deoxyribonucleate pyrimidine dimer lyase (photosensitive), CGS 20267, HER2, breastfalseRNA sequencing data of 142 samples from 142 patients with HER2+ breast cancer treated with letrozole or tamoxifen (SOLTI PAMELA trial)PAMELA (NCT01973660) is a non-randomized, open-label, multicentric, prospective translational research study in stage I-IIIA HER2+ breast cancer designed to evaluate the ability of the PAM50 intrinsic subtypes to predict pCR in the breast (pCRB) following 18 weeks of neoadjuvant lapatinib and trastuzumab (+/- hormonal therapy if hormone receptor [HR] positive). Patients with HR+ disease received letrozole (if postmenopausal) or tamoxifen (if pre-menopausal). The primary objective was to compare the pCRB rates of the HER2-E versus the non-HER2-E subtypes in the intent-to-treat population.2023-04-24 13:10:03EGAS000010064109606EGAD00010002478EGAD00001009054EGAC00001002760