EGAGenomicsCancer Genomicshttps://ega-archive.org/studies/EGAS00001006605EGAEGA study EGAS00001006605Ovarian Carcinosarcoma DNA and RNA sequencing of patient samples in the UK cohort.EGArestrictedovarian malignant mesodermal (Müllerian) mixed tumor, RNA, ovarian malignant mixed mesodermal Mullerian neoplasm, DNS, RNA Sequence Determination, (Deoxyribonucleotide)n, RNA Sequence Determinations, malignant mixed mesodermal Müllerian tumor of ovary, malignant mixed mesodermal Müllerian neoplasm of the ovary, Sequence Determination, DNAn+1, ovarian carcinosarcoma/malignant mixed mesodermal tumor, RNA Sequence, Double-Stranded, Deoxyribonucleic acids, Determinations, (Deoxyribonucleotide)n+m, ovarian malignant mixed Müllerian neoplasm, ovarian malignant mixed epithelial mesenchymal tumor, Client., Deoxyribonucleic Acid, ovarian malignant mixed mesodermal Mullerian tumor, ovarian malignant mixed mesodermal Müllerian neoplasm, Analysis, ovarian malignant mixed mesodermal (Mullerian) tumor, ds-DNA, desoxyribose nucleic acid, carcinosarcoma of ovary, ovarian malignant mixed Müllerian tumor, ovarian malignant mixed mesodermal (Müllerian) tumor, ovarian malignant mixed Mullerian tumor, malignant mixed mesodermal Müllerian tumor of the ovary, thymus nucleic acid, malignant mixed mesodermal Mullerian tumor of the ovary, malignant mixed mesodermal Mullerian neoplasm of the ovary, malignant mixed mesodermal Mullerian neoplasm of ovary, Analyses, Determination, MMMT of the ovary, Double Stranded, Deoxyribonucleic acid, Sequence Determinations, ovarian MMMT, Sequencing, ovary carcinosarcoma, carcinosarcoma of the ovary, RNA Sequence Analyses, Patient, Clients, RNA Sequence Analysis, ovarian malignant mesodermal (Mullerian) mixed tumor, ds DNA, ovarian carcinosarcoma, Desoxyribonukleinsaeure, ovarian malignant mixed Mullerian neoplasm, RNA Sequencing, malignant mixed Müllerian tumor of the ovary, Double-Stranded DNA, ovarian malignant mesodermal (mullerian) mixed tumor, (Deoxyribonucleotide)m, DNA, deoxyribonucleic acids, DNAn, malignant mixed mesodermal Müllerian neoplasm of ovary, ovarian malignant mixed mesodermal Müllerian tumor, malignant mixed mesodermal Mullerian tumor of ovary, Sequence AnalysesTcsk, ovarian malignant mesodermal (Müllerian) mixed tumor, other disease, DNS, RNA Sequence Determination, single-organism developmental process, (Deoxyribonucleotide)n, malignant mixed mesodermal Müllerian neoplasm of the ovary, Sequence Determination, Organic cation transporter 3, Neoplasms, RNA Sequence, postnatal development, Spindle Cell Sarcomas, Malignant Epithelial Tumors, Gene, growth and development, OCT3, neurotubule, Tumor, Epithelial Tumors, Malignant, Deoxyribonucleic acids, Undifferentiated Carcinomas, ovarian malignant mixed Müllerian neoplasm, ovarian malignant mixed epithelial mesenchymal tumor, "epithelial carcinoma" EXACT [NCI2004_11_17:C2916], Deoxyribonucleic Acid, Soft Tissue Sarcoma, diseases, disease or disorder, diseases and disorders, no subtype (morphologic abnormality)" EXACT [SNOMEDCT_2005_07_31:68453008], Analysis, ovarian malignant mixed mesodermal (Mullerian) tumor, Immune., Malignant Epithelial, Epithelioma, Carcinomatosis, tumour of soft tissue and skeleton, microtubulus, carcinosarcoma of ovary, EMTH, ovarian malignant mixed Müllerian tumor, ovarian malignant mixed Mullerian tumor, malignant mixed mesodermal Müllerian tumor of the ovary, study, Sarcomas, Spindle-Cell Carcinoma, Immune Processes, thymus nucleic acid, human disease, Immune Responses, Undifferentiated, Gene Expressions, Analyses, Determination, Epithelial Neoplasms, MMMT of the ovary, inhibiteur, Double Stranded, LPFS1, Deoxyribonucleic acid, tumor of soft tissue and skeleton, epithelial-mesenchymal transition, Sequence Determinations, Expressions, Sequencing, LYK, ovary carcinosarcoma, non-neoplastic, Sarcoma, Immune Response, Immune, inhibidor, RNA Sequence Analyses, Clients, ovarian malignant mesodermal (Mullerian) mixed tumor, ovarian malignant mixed Mullerian neoplasm, mesenchymal cell differentiation from epithelial cell, RNA Sequencing, disorder, Homo sapiens disease, Double-Stranded DNA, microtubuli, (Deoxyribonucleotide)m, malignant Epithelioma, Expression, deoxyribonucleic acids, DNAn, Spindle Cell Sarcoma, Immune Process, malignant mixed mesodermal Mullerian tumor of ovary, connective and soft tissue neoplasm, Sequence Analyses, inhibitors, Carcinoma, sarcoma, RNA, ovarian malignant mixed mesodermal Mullerian neoplasm, Undifferentiated Carcinoma, epithelioma, Process, RNA Sequence Determinations, malignant mixed mesodermal Müllerian tumor of ovary, malignant, DNAn+1, ovarian carcinosarcoma/malignant mixed mesodermal tumor, disorders, "carcinoma" EXACT [CSP2005:2000-1867], inhibitor, "carcinoma, medical condition, Double-Stranded, Client, Anaplastic, Determinations, (Deoxyribonucleotide)n+m, development, epithelial cancer, Epitheliomas, Epithelioid Sarcomas, "carcinoma NOS (morphologic abnormality)" EXACT [SNOMEDCT_2005_07_31:189549006], EMT, Tsk, Emt, Diseases, Neoplasm, Spindle-Cell Carcinomas, Malignant Epithelial Neoplasms, ovarian malignant mixed mesodermal Mullerian tumor, ovarian malignant mixed mesodermal Müllerian neoplasm, condition, ds-DNA, desoxyribose nucleic acid, Microtubule, Carcinomatoses, Epithelioid, ovarian malignant mixed mesodermal (Müllerian) tumor, Carcinomas, Anaplastic Carcinoma, antagonists, malignant mixed mesodermal Mullerian tumor of the ovary, malignant mixed mesodermal Mullerian neoplasm of the ovary, Spindle Cell, malignant mixed mesodermal Mullerian neoplasm of ovary, PSCTK2, postnatal growth, Soft Tissue Sarcomas, Epithelial Neoplasm, sarcoma of the soft tissue and bone, ovarian MMMT, carcinosarcoma of the ovary, disease, Patient, sarcoma of soft tissue and bone, antagonists and inhibitors, Epithelioid Sarcoma, Spindle-Cell, RNA Sequence Analysis, mesenchymal tumor, ds DNA, ovarian carcinosarcoma, Desoxyribonukleinsaeure, Malignant Epithelial Neoplasm, Response, malignant mixed Müllerian tumor of the ovary, ovarian malignant mesodermal (mullerian) mixed tumor, Anaplastic Carcinomas, Malignant Epithelial Tumor, Extraneuronal monoamine transporter, DNA, Epithelial Tumor, malignant mixed mesodermal Müllerian neoplasm of ovary, ovarian malignant mixed mesodermal Müllerian tumor, growth, Soft TissuefalseDNA and RNA sequencing data from Ovarian Carcinosarcoma patients from the Glasgow Cohort.In this study, we analysed DNA and RNA sequencing data from Ovarian Carcinosarcoma patients, from isolated carcinoma and sarcoma components and investigated DNA variants as well as gene expression. Genomic analyses from this data and further investigation from preclinical models of ovarian carcinosarcoma support the conversion theory for disease development and indicate that microtubule inhibitors could be used to suppress EMT and stimulate anti-tumour immunity.2023-06-23 07:25:07EGAS000010066059606EGAD00001011068EGAC00001003299