{"database":"EGA","file_versions":[],"scores":null,"additional":{"omics_type":["Genomics"],"study_type":["Cancer Genomics"],"full_dataset_link":["https://ega-archive.org/studies/EGAS00001007087"],"host":["EGA"],"description":["EGA study EGAS00001007087"],"dataset_title":["Lifelines-CH: core phenotypic variables","Lifelines-CH: processed somatic variant calls"],"category":["restricted"],"repository":["EGA"],"additional_accession":[]},"is_claimable":false,"name":"Evolutionary landscape of clonal hematopoiesis in 3359 individuals from the general population","description":"This project contains longitudinal data for processed somatic variant calls and data on core phenotypic variables for 3359 community-based individuals ≥60 years, a sub-cohort of the population-based Lifelines cohort (167,729 participants). Cases with peripheral blood count abnormalities and population-based controls were included. Next-generation sequencing data were generated with a median time period of 43 months between baseline and follow-up visit. For 327 individuals a third visit sample was included. Error-corrected sequencing was performed using single-molecule tagged molecular inversion probes targeting 27 myeloid and lymphoid driver genes. The threshold for variant calling was set at ≥1% VAF and ≥10 consensus variant reads. Details on sample selection, sequencing technique, variant calling procedures and data curation are described (van Zeventer et al. 2023).","dates":{"updated":"2023-04-25 17:02:53"},"accession":"EGAS00001007087","cross_references":{"TAXONOMY":["9606"],"EGA":["EGAD00001010145","EGAD00001010144","EGAC00001003133"]}}