EGAGenomicsCancer Genomicshttps://ega-archive.org/studies/EGAS00001007087EGAEGA study EGAS00001007087Lifelines-CH: core phenotypic variablesLifelines-CH: processed somatic variant callsrestrictedEGAClonal Hematopoiesis of Indeterminate Potential, School Age Populations., School-Age Populations, Populations, School-Age, Clonal Hematopoiesis, Clonal, CCUS Clonal Cytopenia of Undetermined Significance, Idiopathic Cytopenias of Undetermined Significance, School Age, Clonal Cytopenia of Undetermined Significance, ICUS Idiopathic Cytopenias of Undetermined Significance, Age-related, Hematopoiesis, School-Age Population, ARCH Age related Clonal Hematopoiesis, School Age Population, Age-related Clonal, ARCH Age-related Clonal Hematopoiesis, Population, Age-related Clonal Hematopoiesis, Age related Clonal Hematopoiesis, CHIP Clonal Hematopoiesis of Indeterminate PotentialData Archiving, Nip40-1, AT1G11140, Van, VAN, HB-6, DCT1, IPP2A2, Materials, Procedures, BELLRINGER, Effects, selection process, Blood, Gene, Development, ABIN, congenital defects, HIV-1 Nef-interacting protein., PNY, aplasia, Long Term, PHAPII, CG12298, SUB, 5730420M11Rik, van, School-Age, Techniques, method, l(3)04276, DmelCG12298, Method, PBMC, method used in an experiment, Consensus, Studies, SCRAMBLED, defects, CG1977, Effect, KIF20A, Technique, Virion-associated nuclear shuttling protein, School-Age Populations, SET, mVAN, Genetic, BLR, PENNYWISE, Longterm, TAF-I, mei-1794, ipp2a2, hypoplasia, 2pp2a, dre1, Long-Term, ABIN1, Population, Nramp2, CG10574, DmelCG4299, Study, IGAAD, set, 2PP2A, Methodological Studies, DmelCG10574, taf-ibeta, sample, Annotation, Nef, dSET, dSet, SRF9, Long-Term Effect, Consensus Development, School Age Population, T7H20_80, Long-Term Effects, l(3)dre1, REPLUMLESS, phapii, ABIN-1, DMT1, AU018810, whole blood, T7H20.80, STRUBBELIG, igaad, Longterm Effect, StF-IT-1, Procedure, Cistrons, deformities, mk, group, STRUBBELIG-RECEPTOR FAMILY 9, Menstruation, BLH9, LSN, count, Period, I-2PP2A, hVAN, School Age, agenesis, Long Term Effects, Dm I-2, I2PP2A, core, Genetic Materials, BEL1-LIKE HOMEODOMAIN 9, median, DmelCG32315, Naf1, NAF1, CG32315, Genetic Material, LARSON, atresia, Populations, A20-binding inhibitor of NF-kappa-B activation 1, VAAMANA, Peripheral Blood, HLA-DR-associated protein II, ensemble, DI-2, Dlt, I-2Dm, follow up, Nef-associated factor 1, Dub, INV, malformations, CG4299, Methodological, Methodological Study, School Age Populations, sample population, Data Annotation, Longterm Effects, Reticuloendothelial System, I-2PP1, plan specification, dSET/TAF-Ibeta, 2610030F17Rik, TAF-IBETA, Curation, nip40-1, Material, Data, PBMCs, birth defects, anomalies, Cistron, TAF-Ibeta, School-Age Population, l(3)62Ba, AA407739, T19D16.8, i2pp2a, Archiving, SCMfalseEvolutionary landscape of clonal hematopoiesis in 3359 individuals from the general populationThis project contains longitudinal data for processed somatic variant calls and data on core phenotypic variables for 3359 community-based individuals ≥60 years, a sub-cohort of the population-based Lifelines cohort (167,729 participants). Cases with peripheral blood count abnormalities and population-based controls were included. Next-generation sequencing data were generated with a median time period of 43 months between baseline and follow-up visit. For 327 individuals a third visit sample was included. Error-corrected sequencing was performed using single-molecule tagged molecular inversion probes targeting 27 myeloid and lymphoid driver genes. The threshold for variant calling was set at ≥1% VAF and ≥10 consensus variant reads. Details on sample selection, sequencing technique, variant calling procedures and data curation are described (van Zeventer et al. 2023).2023-04-25 17:02:53EGAS000010070879606EGAD00001010145EGAD00001010144EGAC00001003133