{"database":"EGA","file_versions":[],"scores":null,"additional":{"omics_type":["Genomics"],"study_type":["Other"],"full_dataset_link":["https://ega-archive.org/studies/EGAS00001007703"],"host":["EGA"],"description":["EGA study EGAS00001007703"],"dataset_title":["NOTCH1 fusion genes in pediatric T-cell lymphoblastic lymphoma hallmark a common high-risk subgroup with blood TARC levels as possible biomarker"],"repository":["EGA"],"category":["restricted"],"description_synonyms":["Biological Markers, Viral Marker, SCYA17, xnotch, Materials, Surrogate Endpoints, hN1, Laboratory, lymphoblastic, Biochemical, Endpoint, T-Lymphocyte, Germinoblastoma, Risk Factor Score, Tumor, Serum, Relative, Malignant Lymphomas, NK?, Laboratory Markers, relapse, Risk Factors, NOTCH, T Lymphocyte, Biological, Relapses, immature T cell, Lymphomas, notch, Correlates, Reticulolymphosarcoma, Prognoses, T-Cells, Recurrences, T, Ibm, elevated, Social, T Cells, Malignant Lymphoma, Sarcoma, Immune, Markers, notch1-a, CG6570, Health Correlates, Viral Markers, Xotch, Therapies, Malignancies, Thymus Dependent Lymphocytes, Tumors, Therapy, Relapse, Viral, Surrogate Endpoint, 9930111A19Rik, Biochemical Markers, lin-12, Biologic Marker, Reticulolymphosarcomas, Motch, Benign, T-Cell, Recrudescence, Marker, Relative Risks, Score, Genetic Materials, Germinoblastic, Genetic Material, DmelCG6570, xnotch1, T-cell, absence, Factors, Social Risk Factors, death rate, Risk, End Points, Prognostic, Thymus-Dependent, Scya17, common, Benign Neoplasms, INSDC_feature:gene, MLYM, Immunologic, T-lymphocyte, Germinoblastomas, Laboratory Marker, Treatments, Thymus-Dependent Lymphocyte, Malignant Neoplasms, Social Risk, Scya17l, Health, T cell, lymphoma, Patient, Biochemical Marker, Material, Lymphoma, Cells, AOS5, Cistron, T Cell, notch-1, TAN1, Tan1, Mis6, Prognostic Factor, Thymus-Dependent Lymphocytes, Clinical Markers, Clinical Marker, Neoplasms, Benign Neoplasm, Gene, CG2374, Prognostic Factors, Malignant, Germinoblastic Sarcoma, A-152E5.3., Surrogate End Points, Surrogate Markers, heredity, Risk Factor, portion of blood, Sarcomas, Biomarker, study, Populations at Risk, Clinical, Genetic, Malignancy, Recrudescences, Accountings, absent from organism, Biological Marker, Risk Score, Tarc, Population at Risk, Neoplasias, Immunologic Markers, time of survival, Clients, mature T cell, Social Risk Factor, lb, T14, TARC, T Lymphocytes, Immunologic Marker, high elevation, Lymphocyte, Biologic, Cancer, Malignant Neoplasm, whole blood, vertebrate blood, Serum Markers, End Point, Dm.Tsp42Em, Lbm, LBM, Lb, Lbl, Factor, Risk Factor Scores, Cistrons, Client, Cell, Immune Marker, DmelCG2374, N1, MT, survival, Surrogate End Point, Neoplasm, Germinoblastic Sarcomas, lbl, T lymphocyte, Relative Risk, Biologic Markers, Serum Marker, ABCD-2, Surrogate, Risks, Endpoints, nkch4, Lymphocytes, Cancers, Surrogate Marker, Risk Scores, Therapeutic, AOVD1, Treatment, Abcd-2, NKch4, Neoplasia, lymphoid cancer, Immune Markers"],"name_synonyms":["SCYA17, Biological Markers, Viral Marker, Thymus-Dependent Lymphocytes, xnotch, Materials, Surrogate Endpoints, hN1, Clinical Markers, Laboratory, Clinical Marker, A-152E5.3, lymphoblastic, Biochemical, Gene, Endpoint, T-Lymphocyte, Germinoblastoma, Serum, Malignant, Germinoblastic Sarcoma, Surrogate End Points, Relative, Malignant Lymphomas, Surrogate Markers, Laboratory Markers, NOTCH, T Lymphocyte, Biological, notch, immature T cell, Lymphomas, Reticulolymphosarcoma, portion of blood, Sarcomas, Biomarker, Genetic, Clinical, T-Cells, Biological Marker, T, Tarc, T Cells, Malignant Lymphoma, Sarcoma, Immunologic Markers, Immune, notch1-a, Markers, Viral Markers, mature T cell, Xotch, biological marker, T14, TARC, T Lymphocytes, Immunologic Marker, Thymus Dependent Lymphocytes, Lymphocyte, Biologic, Viral, whole blood, Surrogate Endpoint, Immune Markers., vertebrate blood, Serum Markers, End Point, 9930111A19Rik, Biochemical Markers, lin-12, Cistrons, Biologic Marker, Cell, Immune Marker, N1, Motch, Reticulolymphosarcomas, T-Cell, Marker, Surrogate End Point, Relative Risks, Genetic Materials, Germinoblastic Sarcomas, Germinoblastic, T lymphocyte, Genetic Material, Relative Risk, Biologic Markers, xnotch1, T-cell, Serum Marker, Risk, End Points, ABCD-2, Surrogate, Thymus-Dependent, Risks, Endpoints, Scya17, common, Lymphocytes, MLYM, Immunologic, T-lymphocyte, Germinoblastomas, Laboratory Marker, Surrogate Marker, Thymus-Dependent Lymphocyte, Scya17l, T cell, lymphoma, Material, Biochemical Marker, AOVD1, Lymphoma, AOS5, Cells, Cistron, notch-1, T Cell, TAN1, Tan1, Abcd-2, Mis6, lymphoid cancer"],"additional_accession":[]},"is_claimable":false,"name":"NOTCH1 fusion genes in pediatric T-cell lymphoblastic lymphoma hallmark a common high-risk subgroup with blood TARC levels as possible biomarker","description":"T-cell lymphoblastic lymphoma (T-LBL) is a common pediatric malignancy accounting for approximately 20% of the non-Hodgkin lymphomas during childhood. Survival rates of T-LBL are ~80%, but outcome after relapse is dismal, with salvage rates reaching only ~15. Considering the extremely poor prognosis after relapse and absence of clinically relevant high-risk genetics, there is an urgent need for the identification of molecular risk factors and new prognostic biomarkers in T-LBL, as well as identification of new therapeutic strategies. In this study we present a novel entity of high-risk pediatric T-LBL patients characterized by previously unknown NOTCH1 gene fusions and highly elevated blood TARC levels","dates":{"updated":"2024-06-21 12:49:52"},"accession":"EGAS00001007703","cross_references":{"TAXONOMY":["9606"],"EGA":["EGAD00001015255","EGAC00001001864"]}}