{"database":"EGA","file_versions":[],"scores":null,"additional":{"omics_type":["Genomics"],"study_type":["Gene Regulation Study"],"full_dataset_link":["https://ega-archive.org/studies/EGAS00001007786"],"host":["EGA"],"description":["EGA study EGAS00001007786"],"dataset_title":["Genomic Advances in Sepsis (GAinS) genotyping"],"repository":["EGA"],"category":["restricted"],"name_synonyms":["Pyohemia, Pyaemias, Pyemias, Septicemia, Blood Poisoning, Poisonings, Pyaemia, Blood Poisonings, Blood, Pyohemias, Septicemias., Infection, Pyemia, Bloodstream Infection, Bloodstream Infections, Severe Sepsis, Sepsis, Poisoning, Infection in blood stream, Severe, Bloodstream"],"description_synonyms":["Pyohemia, Pyemias, Lung, Inflammations, DNS, PhrB photolyase activity, (Deoxyribonucleotide)n, Blood, adult stage, SCF receptor activity, Xkl-1, photoreactivating enzyme activity, Infection in blood stream, pigmented epithelium, Septicemias, Deoxyribonucleic acids, Experimental Lung Inflammations, Publication., Pyaemias, KL receptor activity, method, Septicemia, peritonitis, Gsfsco1, Pneumonias, Structural, Deoxyribonucleic Acid, scfr, Publication, isolation, Experimental Lung, PBMC, method used in an experiment, Lung Inflammation, Functional, SCO5, symptoms, Mass, Screening, Pneumonitis, 3, SCO1, stratum pigmentosa retinae, Pyemia, NUP96, Gsfsow3, SCFR, Gsfsco5, epithelium, adult, Pulmonary, SOW3, Pro-Mega, study, Pneumonia, Fdc, thymus nucleic acid, MOS3, Lobar Pneumonias, deoxyribocyclobutadipyrimidine pyrimidine-lyase activity, PRECOCIOUS, ClinicalHistory, clinical information, Comparative Genomics, pigmented retina, F23A5.3, Double Stranded, Deoxyribonucleic acid, purification, W, DNA cyclobutane dipyrimidine photolyase activity, SUPPRESSOR OF AUXIN RESISTANCE 3, isolation and purification, acute generalized peritonitis, Inflammation, Lung Inflammations, Clients, Bs, Double-Stranded DNA, (Deoxyribonucleotide)m, deoxyribonucleic acids, DNAn, primary bacterial peritonitis, Sl, F23A5_3, inflammation of peritoneum, screening, PRE, retractile mesenteritis, proto-oncogene c-Kit, Genomics, findings, Blood Poisoning, whole blood, Comparative, DNAn+1, deoxyribonucleic cyclobutane dipyrimidine photolyase activity, Tr-kit, Bloodstream Infection, Primary, Severe Sepsis, Functional Genomics, Double-Stranded, Hospital, Client, not genetically inherited, Haplotype, Peritonitis, Experimental Lung Inflammation, (Deoxyribonucleotide)n+m, PBT, MODIFIER OF SNC1, Experimental, Lobar Pneumonia, Screenings, batch, retinal pigment, KIT ligand receptor activity, Mass Screenings, acute generalised peritonitis, deoxyribonucleic photolyase activity, Infection, kl1-A, dipyrimidine photolyase (photosensitive), Pneumonitides, ds-DNA, KIT, Sepsis, desoxyribose nucleic acid, Poisoning, Adults, retinal pigment layer, XKrk1, tyrosine-protein kinase Kit, pbt, c-KIT, RPE, Peripheral Blood, Secondary Peritonitis, photolyase activity, Blood Poisonings, Pulmonary Inflammations, acute pneumonia, signs, Bloodstream Infections, Primary Peritonitis, kit, CD117, study protocol, peritoneum inflammation, Bloodstream, p. pigmentosa retinae, Reticuloendothelial System, plan specification, Secondary, phr A photolyase activity, c-kit, DNA-photoreactivating enzyme, Poisonings, Patient, C-Kit, Pyaemia, Ssm, PBMCs, Pyohemias, ds DNA, Desoxyribonukleinsaeure, xkl-1, Lobar, 2018, microarray, Structural Genomics, Pulmonary Inflammation, deoxyribonucleate pyrimidine dimer lyase (photosensitive), DNA, Severe, krk1"],"additional_accession":[]},"is_claimable":false,"name":"Genomic Advances in Sepsis  GAinS  genotyping","description":"This cohort comprises a subset of pateints enrolled in the Genomic Advances in Sepsis (GAinS) study, an established biobank of adult sepsis patients. Patients with sepsis due to community acquired pneumonia or faecal peritonitis were recruited from 35 hospitals across the UK from 2005-2018, with samples for functional genomics and detailed clinical information collected over the first five days of ICU admission. DNA was extracted from buffy coat or whole blood samples using the Qiagen DNA extraction protocol, the automated Maxwell Blood purification kit (Promega), or the QIAamp Blood Midi kit protocol (Qiagen). Genotyping data were generated using the Illumina HumanOmniExpress BeadChip (295 patients), the Infinium CoreExome BeadChip (655 patients), and the Infinium Global Screening Array BeadChip (307 patients). Genotyping QC and imputation into the Haplotype Reference Consortium was perfomed within each batch. The datasets were combined and following post-imputation filtering data were available on 1168 samples. This data is part of a pre-publication release. For information on the proper use of pre-publication data shared by the Wellcome Trust Sanger Institute (including details of any publication moratoria), please see http://www.sanger.ac.uk/datasharing/","dates":{"updated":"2024-06-21 12:21:06"},"accession":"EGAS00001007786","cross_references":{"TAXONOMY":["9606"],"EGA":["EGAD00001015369","EGAC00001000205"]}}