EGA00190GenomicsCase-Cohort; Case-Control; Cohort; Affected Sib Pairs; Exome SequencingdbGaPEGA study phs000402.v1.p1http://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000402.v1.p1EGArestrictedhttps://ega-archive.org/studies/phs000402.v1.p1Heart, type 2, Herz, Apoplexy, Cryptogenic Ischemic Strokes, Surrogate Endpoints, 2410041A17Rik, Laboratory, noninsulin-dependent diabetes mellitus, CVA (Cerebrovascular Accident), Mini Exon, adult heart, fs(1)M34, Risk Factor Score, atherosclerosis, DmelCG12051, Relative, circulatory vessel, Risk Factors, Body Mass, parenchyma of lung, Biological, whole exome sequencing, cerebrovascular accident, HEL-176, 17alpha)-cholest-5-en-3-ol, Non-Insulin Dependent Diabetes Mellitus, CG4601, 2, Ethnic Group, atherosclerosis of artery, Whole Transcriptome, Transcriptome Sequencing, Fs(3)Hor, 14beta, adult, Correlates, A, average, Cryptogenic Embolism, C, tumor of lung, Atherogeneses, thymus nucleic acid, cyt5C, DHO, Genomes, myocardial infarction (disease), heart or heart like organ, STROKE, CG18572, Cholest-5-en-3beta-ol, CVA - Cerebrovascular accident, Cryptogenic Stroke, Age of onset, Ischemic Stroke, cardiac structure, NTef2, Community Health, Epicholesterol, NIDDM, Social, Cambodian, Ischaemic, Human Genomes, tumor of the lung, Health Correlates, data., ACT, Act, Homo sapiens disease, severe, Hmong Americans, Acute Cerebrovascular Accidents, vertebrate heart, dorsal tube, Infarct, Viral, pulmo, Data Set, Index, Actin/BAP47, Myocardial Infarcts, CTE-II, Infarcts, AACT, Exome, familial, CTE-IIa, lung parenchyma, act, Ach1, hBACH, ACH1, Normalcy, Cryptogenic Embolism Stroke, act42A, Asian unspecified, Fs(3)Sz11, heart disorder, Brain Vascular Accident, GIG25, Acute Cerebrovascular Accident, Su(b), Marker, AFFX-Dros-ACTIN_M_r_at, Relative Risks, Myocardial infarction NOS, Quetelet's Index, actin, Cryptogenic Ischemic, LACH, desoxyribose nucleic acid, heart attack, Complete Transcriptome, CVAs (Cerebrovascular Accident), DmelCG4027, Social Risk Factors, End Points, follow up, Type II Diabetes, Immunologic, Laboratory Marker, Phenotypes, Cerebrovascular accident (disorder), actin5C, myocardial, non-insulin-dependent, stroke disorder, pulmonary, Festa, stroke, ds DNA, Whole Exome Sequencing, CG2684, Preventive Medicine & Public Health, lung neoplasm, Preventive Medicine and Public Health, DNA, (MI), E430016J11Rik, BACH, Infarction, Cerebrovascular accident (disorder) [Ambiguous], hypertension, Community, l(1)Ab, STROKE SYNDROME, Brain, Act5c, whole exome, disorder of heart/pericardium, Pulse Pressure, Cryptogenic Strokes, advanced, DNS, maturity-onset diabetes, (Deoxyribonucleotide)n, Clinical Marker, ACT5C, branchial heart, Cardias, Bach, Normalcies, noninsulin dependent diabetes, Human, Attack - heart, Cardiac, Caucasian, Deoxyribonucleic Acid, heart/pericardial disorder, Cholest-5-en-3-ol (3beta)-, Japanese, Mini-Exon, lung, Asian Indian American, disease or disorder, low-density lipoproteins, Cell growth-inhibiting gene 24|25 protein, RCB1879, neoplasm, neoplasm of the lung, noninsulin-dependent, Ischaemic Stroke, U19, Risk Factor, Acute Ischemic, Stroke/CVA - undefined, portion of blood, Normalities, American, BM040, Complete, Exome Sequencings, PEER, Clinical, Stroke and cerebrovascular accident unspecified, BRWS2, heart/pericardial disease or disorder, Atheroscleroses, Double Stranded, syndrome, Deoxyribonucleic acid, Sequencing, Genotypes, Population at Risk, Asians, BMI, fs(1)829, Brain Vascular Accidents, anon-EST:fe2D2, Whole Exome, cleft lip/palate-abnormal thumbs-microcephaly syndrome, DmelCG18572, Whole, Nationality, Heart Attack, T11, (Deoxyribonucleotide)m, constitutitional genetic, Vietnamese, Act-5C, lung neoplasm (disease), Biologic, Wake-up Stroke, Individual Health, 42A, CPS, MI - Myocardial infarction, Complete Exome Sequencings, whole blood, DNAn+1, Traits, Serum Markers, dJ393D12.2, disorders, Acute Ischemic Strokes, Hearts, Factor, MI, Cryptogenic Embolism Strokes, Immune Marker, myocardial infarct, Exome Sequencing, Human Genome, beta-actin, Public, Surrogate End Point, Pressure, heart, M32055, (CVA), Act42, condition, Cholesterin, Acute Ischemic Stroke, Relative Risk, Biologic Markers, Cardiovascular, Stroke NOS, Surrogate, PYR1, Asian American, Endpoints, cholest-5-en-3beta-ol, Exon, LDL, Cerebrovascular Accident, Myocardial, Lds, Chinese Americans, diabetes mellitis type 2, Genogroups, Quetelets Index, Acute, Infarctions, stroke syndrome, Stroke and cerebrovascular accident unspecified (disorder), Desoxyribonukleinsaeure, DRORUD, protection against, digenic, BAP47, Cryptogenic Ischemic Stroke, ACTSG, hereditary, Bap47, Myocardial infarction (disorder), Immune Markers, CVA (cerebral vascular accident), undetermined stroke, lung neoplasms, Biological Markers, Viral Marker, adult onset diabetes, single-organism developmental process, Strokes, infarction (MI), Ischemic, ACTG, ACTE, Blood, Biochemical, Endpoint, Korean American, side effects, Serum, cholesterol, Ischaemic Strokes, Act5, csp2, heart trouble, l(1)G0420, Acute Stroke, Laboratory Markers, Filipino American, diseases, CVA, diseases and disorders, AW048865, Vascular Accidents, cerebral infarction, Systolic, SYNDROME, Cardiac infarction, type II diabetes mellitus, human disease, DmelCG2684, (3beta, Juberg-Hayward syndrome, Vietnamese American, non-insulin dependent diabetes, Complete Exome Sequencing, Whole Transcriptome Sequencing, non-insulin dependent diabetes mellitus, type 2 diabetes mellitus, ischemic stroke, genetic, Stroke, Immune, type 2 diabetes mellitus non-insulin dependent, Markers, Quetelet, act 42A, Viral Markers, Cholesterol, Ac5C, CG4027, Therapies, type 2 diabetes, Double-Stranded DNA, deoxyribonucleic acids, associated, DNAn, Heart Attacks, Myocardial infarction, neoplasm of lung, Therapy, diabetes mellitis type II, CHOLESTEROL, l(1)G0330, Surrogate Endpoint, lung tumor, Wake-up, Myocardial Infarct, T2DM - type 2 diabetes mellitus, white, Biochemical Markers, Double-Stranded, LACH1, Cerebrovascular Stroke, Biologic Marker, late onset, Cerebrovascular Apoplexy, results, (Deoxyribonucleotide)n+m, Cambodian Americans, chambered heart, Alpha-1-antichymotrypsin His-Pro-less, Cardiovascular Stroke, Diseases, precocious, DFNA26, Score, NOS, cardium, Individual, Adults, Cerebrovascular, DFNA20, GAT, Cerebrovascular Accidents, neoplasms, Japanese American, Chinese American, Cerebral Stroke, adults, heart/pericardial trouble, Factors, Risk, l(1)G0117, susceptibility to, Exomes, JHS, Actin, Nationalities, beta-actin/Bap47, Treatments, MYOCARDIAL INFARCTION, insulin resistance, insulin resistance-related, early, l(1)G0486, Cerebrovascular Strokes, l(1)G0245, disease, Social Risk, type II, Health, l(1)G0009, ACTL3, Biochemical Marker, Lach1, Horka, beta-lipoproteins, type II diabetes, Infarction of heart, Heart attack, Fs(3)Horka, inherited genetic, lung tumour, heart disease or disorder, heart/pericardial disease, Transcriptome Sequencings, Ischemic Strokes, other disease, l(1)G0010, Hmong American, Cardiac Diseases, Hmong, Complete Exome, FESTA-L, Clinical Markers, FESTA-S, Asian, CG12051, Heart Diseases, Serpin A3, Ximpact, Diastolic Pressure, Deoxyribonucleic acids, Cardiac Disease, disease of heart, Surrogate End Points, coronary arterial tree, l(1)G0025, Surrogate Markers, disease or disorder of heart, Cryptogenic, Vietnamese Americans, Embolism Stroke, non-insulin-dependent diabetes mellitus, DmF2, Cerebral, Investment, lod, Quetelet Index, study, Biomarker, WES, act5C, Populations at Risk, Vascular Accident, Biological Marker, Filipino, Risk Score, Wake up Stroke, disorder of heart, cleft LIP/palate with abnormal thumbs and microcephaly, Wake-up Strokes, non-neoplastic, adult-onset diabetes, Act42a, Stroke NOS (disorder), cardiac pump, CARDIAC DIS, Immunologic Markers, 1700027G07Rik, Korean, Diastolic, Social Risk Factor, disorder, HEART DIS, African unspecified, Chinese, association with, Asian Indian Americans, Immunologic Marker, Cte-II, diabetes, tumour of lung, l(1)G0177, targeted exome capture, data, Disease, myocardial infarction, vertebrate blood, MYOCARDIAL, Ethnic Groups, End Point, medical condition, Risk Factor Scores, Korean Americans, impact-a, development, Cerebrovascular Apoplexya, CAD, Americans, Genogroup, Filipino Americans, ACTA3, ds-DNA, Environment, ISCHSTR, Indian American, Asian Americans, l(1)G0079, Atherogenesis, Serum Marker, atherosclerosis artery, Type 2 Diabetes, Complete Transcriptome Sequencing, Systolic Pressure, diabetes mellitus, atherosclerotic cardiovascular disease, Normality, Myocardial Infarctions, Mini-Exons, CVA - Cerebrovascular accident unspecified, VSCM, Risks, act 5C, Cambodian American, heart disease, Age symptoms begin, tumour of the lung, TRAITS, Surrogate Marker, Cerebral Strokes, coronary vessel, Risk Scores, Japanese Americans, Acute Strokes, Pulse, Pressures, Therapeutic, cardiac disease, Treatment, Lungs, INFARCTION (MI), Cardiovascular Strokes, Orocraniodigital syndrome, RWDD5, Actin5C, CEREBROVASCULAR ACCIDENTneoplasm of lung, vertebrate heart, dorsal tube, targeted exome capture, lung neoplasms, Herz, pulmo, Complete Exome Sequencings, whole blood, lung tumor, Complete Exome, vertebrate blood, Exome, lung parenchyma, branchial heart, adult heart, Hearts, circulatory vessel, Exome Sequencing, chambered heart, parenchyma of lung, heart, whole exome sequencing, lung, Whole Transcriptome, Transcriptome Sequencing, cardium, neoplasm, neoplasm of the lung, neoplasms, portion of blood, tumor of lung, WES, Complete Transcriptome, Complete, Juberg-Hayward syndrome, Complete Transcriptome Sequencing, Exome Sequencings, heart or heart like organ, Complete Exome Sequencing, Whole Transcriptome Sequencing, JHS, cardiac structure, tumour of the lung, Sequencing, cleft LIP/palate with abnormal thumbs and microcephaly., cardiac pump, Whole Exome, tumor of the lung, pulmonary, cleft lip/palate-abnormal thumbs-microcephaly syndrome, Whole, Whole Exome Sequencing, Lungs, lung tumour, lung neoplasm, lung neoplasm (disease), Transcriptome Sequencings, Orocraniodigital syndrome, tumour of lung19falseNational Heart Lung and Blood Institute (NHLBI) GO-ESP: Heart Cohorts Component of the Exome Sequencing Project (JHS)<p>The NHLBI "Grand Opportunity" Exome Sequencing Project (GO-ESP), a signature project of the NHLBI Recovery Act investment, was designed to identify genetic variants in coding regions (exons) of the human genome (the "exome") that are associated with heart, lung and blood diseases. These and related diseases that are of high impact to public health and individuals from diverse racial and ethnic groups will be studied. These data may help researchers understand the causes of disease, contributing to better ways to prevent, diagnose, and treat diseases, as well as determine whether to tailor prevention and treatments to specific populations. This could lead to more effective treatments and reduce the likelihood of side effects. GO-ESP is comprised of five collaborative components: 3 cohort consortia - HeartGO, LungGO, and WHISP - and 2 sequencing centers - BroadGO and SeattleGO.</p> <p>HeartGO is a consortium of six well-phenotyped NHLBI cohorts: Atherosclerosis Risk in Communities (ARIC) study, the Coronary Artery Risk Development in Young Adults (CARDIA) study, the Cardiovascular Health Study, the Framingham Heart Study, the Jackson Heart Study, and the Multi-Ethnic Study of Atherosclerosis. Together, these cohorts have provided DNA and phenotype datasets from a diverse cohort of individuals of African-American, Caucasian, Asian, and Hispanic ancestry to be made available for use by qualified investigators in dbGaP. HeartGO investigators will conduct genotype-phenotype analyses for phenotypes related not only to heart disease but with other variables that will be contributed to dbGaP. The HeartGO dataset provides investigators with genotype-phenotype analytic opportunities for traits not only related to heart disease but also associated with ancillary variables that will be contributed to dbGaP, including disease endpoints, risk factors, biomarkers, and subclinical disease measures.</p> <p>The phenotypes planned for investigation as part of the GO-ESP HeartGO project include early-onset myocardial infarction (EOMI), low density lipoprotein (LDL) cholesterol, body mass index/type 2 diabetes (BMI/T2D), blood pressure and ischemic stroke. Results of the proposed analyses as well as relevant replication/follow-up analyses will be reported in peer-reviewed journals.</p> <p>This study phs000402 contains the Jackson Heart Study (JHS) subset of GO-ESP/Heart-GO. Additional GO-ESP data is also available via dbGaP.</p>
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