FAIRDOMHubModelsAndrew Millarhttps://fairdomhub.org/models/246?version=1Matlab packageUniversity of EdinburghFAIRDOMHubClock-regulated pathways coordinate the response of many developmental processes to changes in photoperiod and temperature. We model two of the best-understood clock output pathways in Arabidopsis, which control key regulators of flowering and elongation growth. In flowering, the model predicted regulatory links from the clock to cycling DOF factor 1 (CDF1) and flavin-binding, KELCH repeat, F-box 1 (FKF1) transcription. Physical interaction data support these links, which create threefold feed-forward motifs from two clock components to the floral regulator FT. In hypocotyl growth, the model described clock-regulated transcription of phytochrome-interacting factor 4 and 5 (PIF4, PIF5), interacting with post-translational regulation of PIF proteins by phytochrome B (phyB) and other light-activated pathways. The model predicted bimodal and end-of-day PIF activity profiles that are observed across hundreds of PIF-regulated target genes. In the response to temperature, warmth-enhanced PIF4 activity explained the observed hypocotyl growth dynamics but additional, temperature-dependent regulators were implicated in the flowering response. Integrating these two pathways with the clock model highlights the molecular mechanisms that coordinate plant development across changing conditions.Linked circadian outputs control elongation growth and flowering in response to photoperiod and temperature.Seaton Daniel D DD, Smith Robert W RW, Song Young Hun YH, MacGregor Dana R DR, Stewart Kelly K, Steel Gavin G, Foreman Julia J, Penfield Steven S, Imaizumi Takato T, Millar Andrew J AJ, Halliday Karen J KJSocial, Regulations, floral evocation, Social Control, Formal Social Control, flowering, Effects, Longterm, Long Term Effects, Hypocotyls., Control, Longterm Effect, regulation, Long-Term Effect, Long-Term, Controls, Regulation, Effect, Formal Social Controls, Long-Term Effects, Social Controls, Long Term, Longterm Effectspreventive measures, response to day length, development, floral evocation, Controlling, response to photoperiod, preventive therapy, reference sample, response to night length, control, growth pattern, flowering, prophylaxis, non-developmental growth, postnatal development, postnatal growth, growth and development, prevention and control, growth, Controlled, prevention, Temperatures.dmBest1, Materials, Activity, Kelch Domains, A., f box 1, postnatal development, Gene, growth and development, Visible Light, MFL8.13, Development, 5330400M04Rik, Light-Dark Cycle, Dark-Light Cycles, anon-WO0118547.380, DmelCG6264, dIKK-gamma, prevention, Cardaminopsis, MFL8_13, Ly113, Plant Developments., clk, SRL2, PhyB, Arabidopsis thalianas, Plant Morphogenesis, responsivity, A. thalianas, DmIKK-gamma, Cycle, thalianas, Gene Products, ARB, dmIKKgamma, Light Cycles, IKK[[gamma]], ADO3, prevention and control, IKKg, KEY, Key, bHLHe8, Cycles, reactivity, Kelch, Genetic, reference sample, Cresses, flowering, HCAP, VMD2, Mouse-ear Cress, Morphogenesis, KAT13D, mKIAA0334, BMD, Visible, DSEP, Kelch Motifs, Mouse-ear, Kelch Domain, preventive measures, Phytochrome B Protein, TNFSF14, T23K23_10, Daylight Cycles, IKK, Light Dark Cycle, PIF, plant development, Cress, Motifs, TR2, Mouse ear, T23K23.10, Phytochrome, Arabidopses, transcription from bacterial-type RNA polymerase promoter, HHT1, Controlled, RP50, Light-Dark, floral evocation, Controlling, preventive therapy, Radiation, CG6264, Edg, UNQ391/PRO726, Arabidopsis thaliana, Proteins, CELL GROWTH DEFECT FACTOR 1, Light, A. thaliana, phytochrome interacting factor 4, XClock, CD258, Cistrons, PhyB Phytochrome, predicted, flavin-binding, development, IKKgamma, DmIKKgamma, LIGHT, Temperatures, dIKK, Protein, Kenny, feed, Hypocotyls, Genetic Materials, Daylight, AIDD, regulator, Light-Dark Cycles, Daylight Cycle, TU15B, END, Plant Morphogeneses, Genetic Material, dBest1, Visible Radiations, Radiations, Light Cycle, Dbest, Visible Radiation, Kelch Motif, HVEML, best, growth pattern, Dmikkgamma, HVEM-L, prophylaxis, non-developmental growth, Kelch Repeats, dbest1, IKK-gamma, postnatal growth, Photoradiation, Plant, thaliana, DCD-1, Morphogeneses, Kelch Repeat Type 1, Kelch Repeat Type 2, C15orf20, Mouse-ear Cresses, CG16910, MYJ24_3, Developments, LTg, kelch repeat, Protein Gene Products, Gene Proteins, Xclk, Dark-Light Cycle, Dark-Light, Arabidopsis, DmelCG16910, Photoradiations, control, Material, MYJ24.3, bacterial transcription, Dark Light Cycle, Cistron, Photoperiods, response, ORW1, growth, BEST, General activity, MotifSocial, Regulations, floral evocation, Social Control, Formal Social Control, flowering, Effects, Longterm, Long Term Effects, Hypocotyls., Control, Longterm Effect, regulation, Long-Term Effect, Long-Term, Controls, Regulation, Effect, Formal Social Controls, Long-Term Effects, Social Controls, Long Term, Longterm EffectsfalseModelling circadian regulation of flowering time and hypocotyl elongation, Seaton et al., 2015Modelling circadian regulation of flowering time and hypocotyl elongation, Seaton et al., 20152017-02-062022-04-152017-02-062022-04-1524625600997