{"database":"FAIRDOMHub","file_versions":[],"scores":null,"additional":{"omics_type":["Models"],"submitter":["Sara Jabbari"],"full_dataset_link":["https://fairdomhub.org/models/33?version=1"],"ModelFormat":["Matlab package"],"submitter_affiliation":["University of Nottingham"],"repository":["FAIRDOMHub"],"pubmed_abstract":["Bacillus subtilis cells may opt to forgo normal cell division and instead form spores if subjected to certain environmental stimuli, for example nutrient deficiency or extreme temperature. The resulting spores are extremely resilient and can survive for extensive periods of time, importantly under particularly harsh conditions such as those mentioned above. The sporulation process is highly time and energy consuming and essentially irreversible. The bacteria must therefore ensure that this route is only undertaken under appropriate circumstances. The gene regulation network governing sporulation initiation accordingly incorporates a variety of signals and is of significant complexity. We present a model of this network that includes four of these signals: nutrient levels, DNA damage, the products of the competence genes, and cell population size. Our results can be summarised as follows: (i) the model displays the correct phenotypic behaviour in response to these signals; (ii) a basal level of sda expression may prevent sporulation in the presence of nutrients; (iii) sporulation is more likely to occur in a large population of cells than in a small one; (iv) finally, and of most interest, PhrA can act simultaneously as a quorum-sensing signal and as a timing mechanism, delaying sporulation when the cell has damaged DNA, possibly thereby allowing the cell time to repair its DNA before forming a spore."],"pubmed_title":["Mathematical modelling of the sporulation-initiation network in Bacillus subtilis revealing the dual role of the putative quorum-sensing signal molecule PhrA."],"pubmed_authors":["Jabbari Sara S, Heap John T JT, King John R JR"],"description_synonyms":["Centers, Networks, Bacillus subtilis var. natto, Bacillus natto, and Consortia, Mathematics, Bacillus mesentericus, Math, Consortium or Network, Bacillus subtilis8, spore formation, Network Device, Bacillus uniflagellatus., initiation, Network, Bacillus subtilis/Bacillus globigii, Bacillus subtilis (natto), sporulation, ascospore biosynthesis, Mathematical, Vibrio subtilis, Bacillus subtilis subsp. natto, Network Interface, Natto Bacteria, Bacillus globigii, Consortium, NCI Consortium or Network"],"pubmed_title_synonyms":["Bacillus subtilis var. natto, Bacillus natto, molecula., molecules, Bacillus mesentericus, Bacillus subtilis8, spore formation, initiation, Molekuel, neutral molecular compounds, Bacillus subtilis/Bacillus globigii, Bacillus subtilis (natto), Bacillus uniflagellatus, sporulation, Concept, ascospore biosynthesis, Role Concept, Roles, Vibrio subtilis, Bacillus subtilis subsp. natto, Role Concepts, Role, Concepts, Natto Bacteria, Bacillus globigii, molecule"],"pubmed_abstract_synonyms":["Forms, Ip3r, Materials, 2410041A17Rik, ACTG, ACTE, Mbp1, Phases, fs(1)M34, csp2, Act5, Divisions, Long Term, l(1)G0420, DmelCG12051, dmTAF[[II]]230, School-Age, ascospore biosynthesis, Bacillus subtilis subsp. natto, HEL-176, CG4601, 3, Nutrient, myd, Effect, OpT1, A, strong, C, thymus nucleic acid, Eubacteria, M Phases, cyt5C, TFIID TAF250, D6Pas2, DHO, Bacillus mesentericus, cel, M, spore formation, hypoplasia, CG18572, Mbp-1, sporulation, Bacteria Woese et al. 2024, Division Phase, Bacteria <bacteria>, Prokaryotae, act 42A, Ac5C, CG4027, ACT, Act, CG7776, Double-Stranded DNA, Procaryotae, deoxyribonucleic acids, DNAn, Long-Term Effects, single-organism behavior, dTAF[[II]]230, anatomical protrusion, l(1)G0330, gyltl1b-b, Actin/BAP47, CTE-II, AACT, e(Pc), OPT, Longterm Effect, TAF200, CTE-IIa, act, InsP3R, Ach1, hBACH, ACH1, Double-Stranded, TAFII-250, TAF250/230, LACH1, Cell Divisions, L[[3]]CP3, results, act42A, (Deoxyribonucleotide)n+m, GIG25, TAFII250, Su(b), Alpha-1-antichymotrypsin His-Pro-less, School Age, MDDGA6, mKIAA0609, AFFX-Dros-ACTIN_M_r_at, GIG24, DFNA26, opt, Genetic Materials, actin, prokaryotes, KIAA0609, LACH, desoxyribose nucleic acid, GAT, DFNA20, Genetic Material, P400, DNA Injury, fg, DNA Injuries, Populations, DmelCG7776, gyltl1b, DmelCG4027, l(1)G0117, mdc1d, expanded, initiation, Actin, CG17603, TAF[[II]], Bacillus subtilis (natto), beta-actin/Bap47, regulation of protein expression, l(1)G0486, l(1)G0245, MDC1D, actin5C, Genotoxic, enr, l(1)G0009, Taf250, enlarged, spine, Material, ACTL3, SR3-5, Lach1, DmelLcp3, E(PC), BG:DS02740.11, anon-48Ac, ds DNA, Cistron, Bacillus globigii, School-Age Population, DNA, BACH, Prokaryota, TAF230, l(1)Ab, big, Act5c, GH05739, d230, l(1)G0010, DNS, (Deoxyribonucleotide)n, Effects, number, ACT5C, Gene, CG12051, Gm10429, dTAFII250, eubacteria, Serpin A3, EfW1, Bach, presence, Bacillus uniflagellatus, regulation of gene product expression, froggy, Deoxyribonucleic acids, Gyltl1a, protrusion, IP3R1, l(1)G0025, large, III, resilient, GH14582, reduced, Deoxyribonucleic Acid, dmTAF1, Taf230, tough, Pcp1, ENSMUSG00000072853, Cell growth-inhibiting gene 24|25 protein, Bacteriobiota, tiny, Yin, TAF250, DmelCG2043, School-Age Populations, Taf200, act5C, Injury, dTAF[[II]]250, Genetic, lcp3, Cell Division Phase, Longterm, cell, MDDGB6, BRWS2, nutrients, Bacillus subtilis8, LCP-3, Double Stranded, Taf1p, Cell Division, LARGE, Deoxyribonucleic acid, Long-Term, CG2913, Population, Division, Monera, fs(1)829, Bacteria (ex Cavalier-Smith 1987), dTAF250, BPFD#36, Act42a, anon-EST:fe2D2, CP3, 1700027G07Rik, Vibrio subtilis, DmelCG18572, great, Natto Bacteria, spore cell., Long-Term Effect, fungi, T11, (Deoxyribonucleotide)m, School Age Population, TAF, Act-5C, Cte-II, Macronutrient, small, l(1)G0177, Spore, nutrient, 42A, bacteria, TAF[[II]]250, LcpIII, CPS, EG:EG0002.1, DNAn+1, dJ393D12.2, l(3)84Ab, BG:DS00004.13, Bacillus subtilis/Bacillus globigii, Cistrons, Cell, dTAF230, Macronutrients, count in organism, CAD, Temperatures, beta-actin, p230, Long Term Effects, M32055, TAF[[II]]250/230, TFIID, Act42, gene regulation, Pcp-1, ACTA3, ds-DNA, LCP3, M Phase, Bacillus subtilis var. natto, Taf[[II]]250, l(1)G0079, Genotoxic Stress, Phase, Bacillus natto, TAF[[II]]230, DMLCP3, underdeveloped, l(2)28-28-12, PYR1, VSCM, DNA Lesion, act 5C, anon-35Fa, TAF[II]250, Itpr-1, OPT1, School Age Populations, Longterm Effects, DmelCG5861, DNA Lesions, DmelCG17603, opt1, anon-35Fc, prokaryote, DmelCG2913, Stress, Desoxyribonukleinsaeure, DRORUD, BAP47, CG2043, ACTSG, Bap47, Actin5C, TAF1"],"name_synonyms":["Centers, Networks, Bacillus subtilis var. natto, Bacillus natto, and Consortia, Mathematics, Bacillus mesentericus, Math, Consortium or Network, Bacillus subtilis8, spore formation, Network Device, Bacillus uniflagellatus., initiation, Network, Bacillus subtilis/Bacillus globigii, Bacillus subtilis (natto), sporulation, ascospore biosynthesis, Mathematical, Vibrio subtilis, Bacillus subtilis subsp. natto, Network Interface, Natto Bacteria, Bacillus globigii, Consortium, NCI Consortium or Network"],"additional_accession":[]},"is_claimable":false,"name":"Mathematical modelling of the sporulation-initiation network in Bacillus subtilis.","description":"Mathematical modelling of the sporulation-initiation network in Bacillus subtilis.","dates":{"created":"2010-06-04","publication":"2014-07-16","submission":"2010-06-04","last_modified":"2014-07-16"},"accession":"33","cross_references":{"pubmed":["20238180"]}}