{"database":"FAIRDOMHub","file_versions":[],"scores":null,"additional":{"omics_type":["Models"],"submitter":["Franco du Preez"],"full_dataset_link":["https://fairdomhub.org/models/60?version=1"],"ModelFormat":[""],"submitter_affiliation":["Manchester Centre for Integrative Systems Biology, University of Manchester"],"repository":["FAIRDOMHub"],"pubmed_abstract":["Staphylococcus aureus is a pathogenic bacterium that utilises quorum sensing (QS), a cell-to-cell signalling mechanism, to enhance its ability to cause disease. QS allows the bacteria to monitor their surroundings and the size of their population, and S. aureus makes use of this to regulate the production of virulence factors. Here we describe a mathematical model of this QS system and perform a detailed time-dependent asymptotic analysis in order to clarify the roles of the distinct interactions that make up the QS process, demonstrating which reactions dominate the behaviour of the system at various timepoints. We couple this analysis with numerical simulations and are thus able to gain insight into how a large population of S. aureus shifts from a relatively harmless state to a highly virulent one, focussing on the need for the three distinct phases which form the feedback loop of this particular QS system."],"pubmed_title":["Mathematical modelling of the agr operon in Staphylococcus aureus."],"pubmed_authors":["Jabbari Sara S, King John R JR, Koerber Adrian J AJ, Williams Paul P"],"pubmed_abstract_synonyms":["Forms, other disease, d230, biological signaling, Virulence, cell-cell signaling involved in quorum sensing, determination, Effects, acetylglucosaminyltransferase-like protein, P62, Mbp1, dTAFII250, eubacteria, sci, EfW1, LARGE1, Long Term, froggy, Gyltl1a, protrusion, Quorum, dmTAF[[II]]230, School-Age, diseases, Quorum Quenchings, dmTAF1, Taf230, Quenching, Pathogenicity Factor, disease or disorder, HOW, How, diseases and disorders, Bacteriobiota, myd, Effect, Staphlococcus pyogenes citreus, l(3)j5D5, TAF250, 24B, School-Age Populations, Taf200, human disease, Eubacteria, anatomical systems, dTAF[[II]]250, l(3)s2612, TFIID TAF250, like-acetylglucosaminyltransferase, cel, Longterm, Staphilococcus aureus, cell, MDDGB6, stru, Mbp-1, Taf1p, Micrococcus aureus, LARGE, l(3)S053606, Long-Term, Population, CG10293, Monera, non-neoplastic, Bacteria Woese et al. 2024, Bacteria (ex Cavalier-Smith 1987), Pathogenicity Factors, dTAF250, l(3)j5B5, BPFD#36, detection of cell density by secreted molecule, Bacteria <bacteria>, Prokaryotae, signaling process, DmelCG10293, disorder, Homo sapiens disease, Long-Term Effect, Staphylococus aureus, fungi, Procaryotae, School Age Population, TAF, Long-Term Effects, single organism signaling, single-organism behavior, bacteria, 0904/17, dTAF[[II]]230, TAF[[II]]250, anatomical protrusion, Sensing, gyltl1b-b, clone 2.39, disorders, TAF200, Longterm Effect, l(3)84Ab, BG:DS00004.13, medical condition, Factor, TAFII-250, qkr, TAF250/230, l(3)S090417, Cell, dTAF230, Virulence Factor, TAFII250, SZ1, p230, School Age, MDDGA6, KH93F, mKIAA0609, Long Term Effects, chemical analysis, Diseases, Pathogenicity, TAF[[II]]250/230, TFIID, condition, prokaryotes, KIAA0609, acetylglucosaminyltransferase-like 1A, who, Quorum Quenching, Quenchings, Taf[[II]]250, fg, Populations, Staphylococcus aureus subsp. anaerobius, TAF[[II]]230, Factors, gyltl1b, distinct, mdc1d, TAF[II]250, Who/How, CG17603, TAF[[II]], LARGE_HUMAN, School Age Populations, signalling, Longterm Effects, Streptococcus aureus, disease, MDC1D, DmelCG17603, Micrococcus pyogenes, Staphylococcus pyogenes aureus, signalling process, like-glycosyltransferase, enr, Taf250, spine, SR3-5, prokaryote, qkr[93F], anon-EST:Liang-2.39, School-Age Population, assay, Feedbacks, anatomical systems., TAF230, Prokaryota, glycosyltransferase-like protein LARGE1, TAF1"],"name_synonyms":["DmelCG9538, PIN-FORMED 2, AGRAVITROPIC ROOT 1, WAV6, ETHYLENE INSENSITIVE ROOT 1, ARABIDOPSIS THALIANA PIN-FORMED 2, Staphylococcus aureus subsp. anaerobius, Mathematics, Math, Staphilococcus aureus, agr, Agr5, Micrococcus aureus, AGR1, AUXIN TRANSPORT PROTEIN EIR1, ATPIN2, MUL3.3, Micrococcus pyogenes, Staphylococcus pyogenes aureus, Streptococcus aureus., Operons, Mathematical, AGR, Agr, AGRAVITROPIC ROOT, WAVY ROOTS 6, CG9538, MUL3_3, Staphylococus aureus, PIN2, Staphlococcus pyogenes citreus, anon-WO0140519.74, POLAR-AUXIN-TRANSPORT EFFLUX COMPONENT AGRAVITROPIC 1"],"description_synonyms":["DmelCG9538, PIN-FORMED 2, AGRAVITROPIC ROOT 1, WAV6, ETHYLENE INSENSITIVE ROOT 1, ARABIDOPSIS THALIANA PIN-FORMED 2, Staphylococcus aureus subsp. anaerobius, Mathematics, Math, Staphilococcus aureus, agr, Agr5, Micrococcus aureus, AGR1, AUXIN TRANSPORT PROTEIN EIR1, ATPIN2, MUL3.3, Micrococcus pyogenes, Staphylococcus pyogenes aureus, Streptococcus aureus., Operons, Mathematical, AGR, Agr, AGRAVITROPIC ROOT, WAVY ROOTS 6, CG9538, MUL3_3, Staphylococus aureus, PIN2, Staphlococcus pyogenes citreus, anon-WO0140519.74, POLAR-AUXIN-TRANSPORT EFFLUX COMPONENT AGRAVITROPIC 1"],"pubmed_title_synonyms":["DmelCG9538, PIN-FORMED 2, AGRAVITROPIC ROOT 1, WAV6, ETHYLENE INSENSITIVE ROOT 1, ARABIDOPSIS THALIANA PIN-FORMED 2, Staphylococcus aureus subsp. anaerobius, Staphilococcus aureus, agr, Agr5, Micrococcus aureus, AGR1, AUXIN TRANSPORT PROTEIN EIR1, ATPIN2, MUL3.3, Micrococcus pyogenes, Staphylococcus pyogenes aureus, Streptococcus aureus., Operons, AGR, Agr, AGRAVITROPIC ROOT, WAVY ROOTS 6, CG9538, MUL3_3, Staphylococus aureus, PIN2, Staphlococcus pyogenes citreus, anon-WO0140519.74, POLAR-AUXIN-TRANSPORT EFFLUX COMPONENT AGRAVITROPIC 1"],"additional_accession":[]},"is_claimable":false,"name":"Mathematical modelling of the agr operon in Staphylococcus aureus","description":"Mathematical modelling of the agr operon in Staphylococcus aureus","dates":{"created":"2011-10-12","publication":"2012-03-07","submission":"2011-10-12","last_modified":"2012-03-07"},"accession":"60","cross_references":{"pubmed":["19688348"]}}