GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE107nnn/GSE107710/primaryOK200TranscriptomicsMus musculusExpression profiling by arrayhttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE107710GEOGSEfalseAlteration of renal gene expression following miR-22 inhibition in rhabdomyolysis (24 h) induced acute kidney injuryIn acute kidney injury (AKI) regions of the kidney are hypoxic. However, for reasons yet unknown, adaptation to hypoxia through hypoxia inducible factor (HIF) is limited. Here we seek for potential HIF repressors, their amenability to intervention, and assess the consequences for AKI outcome Renal miR-22 is up-regulated in AKI. In vitro, miR-22 is inducible by hypoxia, represses HIF, and this repression is offset by specific anti-miR-22 molecules. Inhibition of miR-22 in AKI leads to a complex regulation of more than 3,000 renal genes, most of which are unrelated to the HIF pathway.2019/11/20GSE107710GSM2876369GSM2876358GSM2876359GSM2876370GSM2876371GSM2876360GSM2876372GSM2876361GSM2876373GSM2876362GSM2876374GSM2876363GSM2876375GSM2876364GSM2876376GSM2876365GSM2876377GSM2876366GSM2876356GSM2876378GSM2876367GSM2876379GSM2876368GSM287635723038107710Mus musculus[29791781]