GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE108nnn/GSE108206/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE108206GEOGSEfalseCortex transcriptome analysis of CHD8 Asn2373LysfsX2 heterozygote mutation mice age of P25CHD8, encoding a chromatin remodeling protein, is one of the most frequently mutated genes in autism spectrum disorders. However, how such mutations cause autistic behaviors remain unclear. In mice carrying a heterozygous frame-shift mutation in the Chd8 gene (Asn2373LysfsX2) identified in autistic human individuals, we observed autistic-like behaviors that are much stronger in males than in females, similar to human cases. These behaviors included enhanced mother-seeking ultrasonic vocalizations in pups, mother-attachment behaviors in juveniles, and isolation-induced self-grooming in adults. These behaviors were associated with opposite changes in synaptic excitation/inhibition and neuronal firing in male and female mice, but with strong changes in gene expression in female mice. Therefore, this CHD8 mutation may cause male-preponderant autistic-like behaviors in mice through differential synaptic/neuronal changes and gene expression2026/09/01GSE108206GSM2892291GSM2892292GSM2892295GSM2892296GSM2892293GSM2892294GSM2892299GSM2892300GSM2892297GSM2892298GSM2892301GSM289230213112SRP126944108206Mus musculus