{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE117nnn/GSE117856/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE117856"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"RNAseq from MDA-MB-231 shYB-1 and sh control","description":"Elevated YB-1 expression correlates with poor patient survival and drug resistance in diverse tumor types, notably in metastatic tumors. In this report, we characterized the role of YB-1 in breast tumor initiation and progression, in primary cells or cell lines. Notably, YB-1 blockade in MDA-MB-231 cells shown that YB-1 has a major role in tumor progression and dissemination, but not in in vitro settings. Our data suggests induction of YB-1 expression is associated with the activation of a HIF1α program.","dates":{"publication":"2026/07/08"},"accession":"GSE117856","cross_references":{"GSM":["GSM3311569","GSM3311568","GSM3311567","GSM3311566","GSM3311565","GSM3311564","GSM3311563","GSM3311570"],"GPL":["16791"],"SRA":["SRP155737"],"GSE":["117856"],"taxon":["Homo sapiens"],"PMID":["[34294889]"]}}