GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE117nnn/GSE117856/primaryOK200TranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE117856GEOGSEfalseRNAseq from MDA-MB-231 shYB-1 and sh controlElevated YB-1 expression correlates with poor patient survival and drug resistance in diverse tumor types, notably in metastatic tumors. In this report, we characterized the role of YB-1 in breast tumor initiation and progression, in primary cells or cell lines. Notably, YB-1 blockade in MDA-MB-231 cells shown that YB-1 has a major role in tumor progression and dissemination, but not in in vitro settings. Our data suggests induction of YB-1 expression is associated with the activation of a HIF1α program.2026/07/08GSE117856GSM3311569GSM3311568GSM3311567GSM3311566GSM3311565GSM3311564GSM3311563GSM331157016791SRP155737117856Homo sapiens[34294889]