GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE12nnn/GSE12024/primaryOK2000000GenomicsMus musculusExpression profiling by arrayhttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE12024GEOGSE0falseEffect of Sirolimus treatment on lupus nephritis in NZB/W F1 female miceNZB/WF1 female mice spontaneously develop autoimmune lupus nephritis. Expression profiling of kidney tissue from (a) 12 week NZB/W F1 female mice defined as asymptomatic for lupus nephritis, (b) 36 and 42 week NZB/W F1 female mice defined as diseased/symptomatic for lupus nephritis and (c) 36 and 42 week NZB/W F1 female mice that are diseased/symptomatic for lupus nephritis and treated with Sirolimus was carried out. The goal of the study was to identify genes associated with lupus nephritis and modulated by Sirolimus, an inhibitor of mTOR. In addition, lupus nephritis genes resistant to Sirolimus therapy were also identfied2008/11/21GSE12024GSM303972GSM303971GSM303992GSM303970GSM303991GSM303990GSM303969GSM303968GSM303989GSM303967GSM303988GSM303966GSM303965GSM303987GSM303986GSM303964GSM303985GSM303963GSM303984GSM303962GSM303983GSM303961GSM303982GSM303981GSM303980GSM303979GSM303978GSM303977GSM303976GSM303975GSM303974GSM303973757612024Mus musculus[18980674]