{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE128nnn/GSE128032/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Methylation profiling"],"species":["Homo sapiens"],"gds_type":["Methylation profiling by genome tiling array"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE128032"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Loss of IDH1R132H mediated D-2HG production induces genome-wide demethylation in GCIMP low loci in patient-derived glioma cells","description":"Here, we describe and characterize CRISPR-Cas9 based isogenic cell line models using patient-derived IDH1R132H/WT glioma cell lines, and we use these models to explore changes in DNA methylation following genetic deletion of IDH1 alleles that ablate D2HG production.","dates":{"publication":"2019/11/07"},"accession":"GSE128032","cross_references":{"GSM":["GSM3660636","GSM3660625","GSM3660635","GSM3660634","GSM3660633","GSM3660629","GSM3660639","GSM3660628","GSM3660627","GSM3660638","GSM3660626","GSM3660637","GSM3660632","GSM3660631","GSM3660630","GSM3660640"],"GPL":["21145"],"GSE":["128032"],"taxon":["Homo sapiens"],"PMID":["[31292202]"]}}