{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE142nnn/GSE142751/"]},"type":"primary"},"statusCodeValue":200,"statusCode":"OK"}],"scores":null,"additional":{"omics_type":["Genomics"],"species":["Homo sapiens"],"gds_type":["Genome binding/occupancy profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE142751"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Genome-wide maps of chromatin state in 142 cancer cell lines [cell line]","description":"Epigenetic aberrations are a hallmark of cancer; however, we have limited information on chromatin aberrations present in cancer cells. Here we provide genome-wide maps for histone modification binding for 6 reference histone markers in 145 cancer cell lines belonging to 9 cancer types generating 680 chromatin maps. NMF clustering for H3K27ac-defined enhancers classified cancer cells into 5 distinct subtypes. These subtypes were either correlated with the developmental trajectory of original tissue or cell phenotype such as mesenchymal features. We identify a cluster consisting of different tumor types but with a unique enhancer profile and its dependency on key oncogenes. Detailed characterization of bivalent state switches between cancer cells and their normal counterparts identified epithelial-to-mesenchymal driver transcription factors to be activated via this mechanism in breast, GBM and melanomas. Finally, we identify cancer-specific lengthening of H3K4me3 domains on oncogenes and their shortening on specific tumor-suppressors, respectively. Overall, our study provides epigenome reference maps for widely-used cancer cell lines which will be useful for discovery of important principles about chromatin mediated cancer gene regulation.","dates":{"publication":"2026/07/03"},"accession":"GSE142751","cross_references":{"GSM":["GSM4238837","GSM4238838","GSM4238839","GSM4238830","GSM4238831","GSM4238832","GSM4238833","GSM4238834","GSM4238835","GSM4238836","GSM4238848","GSM4238849","GSM4238840","GSM4238841","GSM4238842","GSM4238843","GSM4238844","GSM4238845","GSM4238846","GSM4238847","GSM4238815","GSM4238816","GSM4238817","GSM4238818","GSM4238819","GSM4238810","GSM4238811","GSM4238812","GSM4238813","GSM4238814","GSM4238826","GSM4238827","GSM4238828","GSM4238829","GSM4238820","GSM4238821","GSM4238822","GSM4238823","GSM4238824","GSM4238825","GSM4238870","GSM4238871","GSM4238872","GSM4238873","GSM4238874","GSM4238875","GSM4238876","GSM4238877","GSM4238878","GSM4238879","GSM4238880","GSM4238881","GSM4238882","GSM4238883","GSM4238884","GSM4238885","GSM4238886","GSM4238887","GSM4238888","GSM4238889","GSM4238850","GSM4238859","GSM4238851","GSM4238852","GSM4238853","GSM4238854","GSM4238855","GSM4238856","GSM4238857","GSM4238858","GSM4238860","GSM4238861","GSM4238862","GSM4238863","GSM4238864","GSM4238865","GSM4238866","GSM4238867","GSM4238868","GSM4238869","GSM4239520","GSM4239521","GSM4239522","GSM4239523","GSM4239524","GSM4239525","GSM4239526","GSM4239527","GSM4239528","GSM4239529","GSM4239530","GSM4239531","GSM4239532","GSM4239533","GSM4239534","GSM4239535","GSM4239536","GSM4239537","GSM4239538","GSM4239539","GSM4238890","GSM4238891","GSM4238892","GSM4238893","GSM4238894","GSM4239508","GSM4239509","GSM4238895","GSM4239500","GSM4239501","GSM4238896","GSM4238897","GSM4239502","GSM4239503","GSM4238898","GSM4238899","GSM4239504","GSM4239505","GSM4239506","GSM4239507","GSM4239510","GSM4239519","GSM4239511","GSM4239512","GSM4239513","GSM4239514","GSM4239515","GSM4239516","GSM4239517","GSM4239518","GSM4239320","GSM4239321","GSM4239322","GSM4239323","GSM4239324","GSM4239325","GSM4239326","GSM4239327","GSM4239328","GSM4239329","GSM4239330","GSM4239331","GSM4239332","GSM4239333","GSM4239334","GSM4239335","GSM4239336","GSM4239337","GSM4239338","GSM4239339","GSM4238690","GSM4238691","GSM4238692","GSM4238693","GSM4239540","GSM4238694","GSM4239541","GSM4239300","GSM4239542","GSM4238695","GSM4238696","GSM4239543","GSM4239301","GSM4238697","GSM4239544","GSM4239302","GSM4239303","GSM4238698","GSM4238699","GSM4239304","GSM4239305","GSM4239306","GSM4239307","GSM4239308","GSM4239309","GSM4239310","GSM4239311","GSM4239312","GSM4239313","GSM4239314","GSM4239315","GSM4239316","GSM4239317","GSM4239318","GSM4239319","GSM4239360","GSM4239361","GSM4239120","GSM4239362","GSM4239363","GSM4239121","GSM4239364","GSM4239122","GSM4239123","GSM4239365","GSM4239366","GSM4239124","GSM4239367","GSM4239125","GSM4239126","GSM4239368","GSM4239369","GSM4239127","GSM4239128","GSM4239129","GSM4239371","GSM4239372","GSM4239130","GSM4239131","GSM4239373","GSM4239132","GSM4239374","GSM4239375","GSM4239133","GSM4239134","GSM4239376","GSM4239377","GSM4239135","GSM4239378","GSM4239136","GSM4239370","GSM4239137","GSM4239379","GSM4239138","GSM4239139","GSM4239340","GSM4239341","GSM4239100","GSM4239342","GSM4239343","GSM4239101","GSM4239344","GSM4239102","GSM4239103","GSM4239345","GSM4239346","GSM4239104","GSM4239105","GSM4239347","GSM4239106","GSM4239348","GSM4239349","GSM4239107","GSM4239108","GSM4239109","GSM4239350","GSM4239351","GSM4239352","GSM4239110","GSM4239111","GSM4239353","GSM4239112","GSM4239354","GSM4239355","GSM4239113","GSM4239114","GSM4239356","GSM4239357","GSM4239115","GSM4239358","GSM4239116","GSM4239117","GSM4239359","GSM4239118","GSM4239119","GSM4239162","GSM4239163","GSM4239164","GSM4239165","GSM4239166","GSM4239167","GSM4239168","GSM4239169","GSM4239160","GSM4239161","GSM4239173","GSM4239174","GSM4239175","GSM4239176","GSM4239177","GSM4239178","GSM4239179","GSM4239170","GSM4239171","GSM4239172","GSM4239140","GSM4239382","GSM4239383","GSM4239141","GSM4239384","GSM4239142","GSM4239143","GSM4239385","GSM4239386","GSM4239144","GSM4239387","GSM4239145","GSM4239146","GSM4239388","GSM4239389","GSM4239147","GSM4239380","GSM4239381","GSM4239148","GSM4239149","GSM4239151","GSM4239393","GSM4239152","GSM4239394","GSM4239395","GSM4239153","GSM4239154","GSM4239396","GSM4239397","GSM4239155","GSM4239398","GSM4239156","GSM4239157","GSM4239399","GSM4239158","GSM4239390","GSM4239391","GSM4239392","GSM4239150","GSM4239159","GSM4239184","GSM4239185","GSM4239186","GSM4239187","GSM4239188","GSM4239189","GSM4239180","GSM4239181","GSM4239182","GSM4239183","GSM4239195","GSM4239196","GSM4239197","GSM4239198","GSM4239199","GSM4239190","GSM4239191","GSM4239192","GSM4239193","GSM4239194","GSM4238914","GSM4238915","GSM4238916","GSM4238917","GSM4238918","GSM4238919","GSM4238910","GSM4238911","GSM4238912","GSM4238913","GSM4238925","GSM4238926","GSM4238927","GSM4238928","GSM4238929","GSM4238920","GSM4238921","GSM4238922","GSM4238923","GSM4238924","GSM4238903","GSM4238904","GSM4238905","GSM4238906","GSM4238907","GSM4238908","GSM4238909","GSM4238900","GSM4238901","GSM4238902","GSM4238716","GSM4238958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