GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE142nnn/GSE142751/primary200OKGenomicsHomo sapiensGenome binding/occupancy profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE142751GEOGSEfalseGenome-wide maps of chromatin state in 142 cancer cell lines [cell line]Epigenetic aberrations are a hallmark of cancer; however, we have limited information on chromatin aberrations present in cancer cells. Here we provide genome-wide maps for histone modification binding for 6 reference histone markers in 145 cancer cell lines belonging to 9 cancer types generating 680 chromatin maps. NMF clustering for H3K27ac-defined enhancers classified cancer cells into 5 distinct subtypes. These subtypes were either correlated with the developmental trajectory of original tissue or cell phenotype such as mesenchymal features. We identify a cluster consisting of different tumor types but with a unique enhancer profile and its dependency on key oncogenes. Detailed characterization of bivalent state switches between cancer cells and their normal counterparts identified epithelial-to-mesenchymal driver transcription factors to be activated via this mechanism in breast, GBM and melanomas. Finally, we identify cancer-specific lengthening of H3K4me3 domains on oncogenes and their shortening on specific tumor-suppressors, respectively. Overall, our study provides epigenome reference maps for widely-used cancer cell lines which will be useful for discovery of important principles about chromatin mediated cancer gene regulation.2026/07/03GSE142751GSM4238837GSM4238838GSM4238839GSM4238830GSM4238831GSM4238832GSM4238833GSM4238834GSM4238835GSM4238836GSM4238848GSM4238849GSM4238840GSM4238841GSM4238842GSM4238843GSM4238844GSM4238845GSM4238846GSM4238847GSM4238815GSM4238816GSM4238817GSM4238818GSM4238819GSM4238810GSM4238811GSM4238812GSM4238813GSM4238814GSM4238826GSM4238827GSM4238828GSM4238829GSM4238820GSM4238821GSM4238822GSM4238823GSM4238824GSM4238825GSM4238870GSM4238871GSM4238872GSM4238873GSM4238874GSM4238875GSM4238876GSM4238877GSM4238878GSM4238879GSM4238880GSM4238881GSM4238882GSM4238883GSM4238884GSM4238885GSM4238886GSM4238887GSM4238888GSM4238889GSM4238850GSM4238859GSM4238851GSM4238852GSM4238853GSM4238854GSM4238855GSM4238856GSM4238857GSM4238858GSM4238860GSM4238861GSM4238862GSM4238863GSM4238864GSM4238865GSM4238866GSM4238867GSM4238868GSM4238869GSM4239520GSM4239521GSM4239522GSM4239523GSM4239524GSM4239525GSM4239526GSM4239527GSM4239528GSM4239529GSM4239530GSM4239531GSM4239532GSM4239533GSM4239534GSM4239535GSM4239536GSM4239537GSM4239538GSM4239539GSM4238890GSM4238891GSM4238892GSM4238893GSM4238894GSM4239508GSM4239509GSM4238895GSM4239500GSM4239501GSM4238896GSM4238897GSM4239502GSM4239503GSM4238898GSM4238899GSM4239504GSM4239505GSM4239506GSM4239507GSM4239510GSM4239519GSM4239511GSM4239512GSM4239513GSM4239514GSM4239515GSM4239516GSM4239517GSM4239518GSM4239320GSM4239321GSM4239322GSM4239323GSM4239324GSM4239325GSM4239326GSM4239327GSM4239328GSM4239329GSM4239330GSM4239331GSM4239332GSM4239333GSM4239334GSM4239335GSM4239336GSM4239337GSM4239338GSM4239339GSM4238690GSM4238691GSM4238692GSM4238693GSM4239540GSM4238694GSM4239541GSM4239300GSM4239542GSM4238695GSM4238696GSM4239543GSM4239301GSM4238697GSM4239544GSM4239302GSM4239303GSM4238698GSM4238699GSM4239304GSM4239305GSM4239306GSM4239307GSM4239308GSM4239309GSM4239310GSM4239311GSM4239312GSM4239313GSM4239314GSM4239315GSM4239316GSM4239317GSM4239318GSM4239319GSM4239360GSM4239361GSM4239120GSM4239362GSM4239363GSM4239121GSM4239364GSM4239122GSM4239123GSM4239365GSM4239366GSM4239124GSM4239367GSM4239125GSM4239126GSM4239368GSM4239369GSM4239127GSM4239128GSM4239129GSM4239371GSM4239372GSM4239130GSM4239131GSM4239373GSM4239132GSM4239374GSM4239375GSM4239133GSM4239134GSM4239376GSM4239377GSM4239135GSM4239378GSM4239136GSM4239370GSM4239137GSM4239379GSM4239138GSM4239139GSM4239340GSM4239341GSM4239100GSM4239342GSM4239343GSM4239101GSM4239344GSM4239102GSM4239103GSM4239345GSM4239346GSM4239104GSM4239105GSM4239347GSM4239106GSM4239348GSM4239349GSM4239107GSM4239108GSM4239109GSM4239350GSM4239351GSM4239352GSM4239110GSM4239111GSM4239353GSM4239112GSM4239354GSM4239355GSM4239113GSM4239114GSM4239356GSM4239357GSM4239115GSM4239358GSM4239116GSM4239117GSM4239359GSM4239118GSM4239119GSM4239162GSM4239163GSM4239164GSM4239165GSM4239166GSM4239167GSM4239168GSM4239169GSM4239160GSM4239161GSM4239173GSM4239174GSM4239175GSM4239176GSM4239177GSM4239178GSM4239179GSM4239170GSM4239171GSM4239172GSM4239140GSM4239382GSM4239383GSM4239141GSM4239384GSM4239142GSM4239143GSM4239385GSM4239386GSM4239144GSM4239387GSM4239145GSM4239146GSM4239388GSM4239389GSM4239147GSM4239380GSM4239381GSM4239148GSM4239149GSM4239151GSM4239393GSM4239152GSM4239394GSM4239395GSM4239153GSM4239154GSM4239396GSM4239397GSM4239155GSM4239398GSM4239156GSM4239157GSM4239399GSM4239158GSM4239390GSM4239391GSM4239392GSM4239150GSM4239159GSM4239184GSM4239185GSM4239186GSM4239187GSM4239188GSM4239189GSM4239180GSM4239181GSM4239182GSM4239183GSM4239195GSM4239196GSM4239197GSM4239198GSM4239199GSM4239190GSM4239191GSM4239192GSM4239193GSM4239194GSM4238914GSM4238915GSM4238916GSM4238917GSM4238918GSM4238919GSM4238910GSM4238911GSM4238912GSM4238913GSM4238925GSM4238926GSM4238927GSM4238928GSM4238929GSM4238920GSM4238921GSM4238922GSM4238923GSM4238924GSM4238903GSM4238904GSM4238905GSM4238906GSM4238907GSM4238908GSM4238909GSM4238900GSM4238901GSM4238902GSM4238716GSM4238958GSM4238717GSM4238959GSM4238718GSM4238719GSM4238950GSM4238951GSM4238710GSM4238952GSM4238711GSM4238953GSM4238954GSM4238712GSM4238713GSM4238955GSM4238714GSM4238956GSM4238957GSM4238715GSM4238960GSM4238969GSM4238727GSM4238728GSM4238729GSM4238961GSM4238962GSM4238720GSM4238963GSM4238721GSM4238722GSM4238964GSM4238965GSM4238723GSM4238966GSM4238724GSM4238725GSM4238967GSM4238968GSM4238726GSM4238936GSM4238937GSM4238938GSM4238939GSM4238930GSM4238931GSM4238932GSM4238933GSM4238934GSM4238935GSM4238705GSM4238947GSM4238948GSM4238706GSM4238949GSM4238707GSM4238708GSM4238709GSM4238940GSM4238941GSM4238942GSM4238700GSM4238943GSM4238701GSM4238702GSM4238944GSM4238945GSM4238703GSM4238946GSM4238704GSM4238990GSM4238991GSM4238992GSM4238750GSM4238751GSM4238993GSM4238994GSM4238752GSM4238753GSM4238995GSM4238754GSM4238996GSM4238997GSM4238755GSM4238756GSM4238998GSM4238757GSM4238999GSM4238758GSM4238759GSM4238760GSM4238761GSM4238762GSM4238763GSM4238764GSM4238765GSM4238766GSM4238767GSM4238768GSM4238769GSM4238970GSM4238971GSM4238738GSM4238739GSM4238972GSM4238730GSM4238731GSM4238973GSM4238974GSM4238732GSM4238733GSM4238975GSM4238734GSM4238976GSM4238735GSM4238977GSM4238736GSM4238978GSM4238737GSM4238979GSM4238980GSM4238981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sapiens