GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE146nnn/GSE146192/suppl/filelist.txtftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE146nnn/GSE146192/suppl/GSE146192_RAW.tarprimaryOK2000002GenomicsYandong ZhengIllumina HiSeq 2000 (Homo sapiens)Homo Sapienshttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE146192zhnegyandong19@mails.ucas.ac.cnINSTITUTE OF ZOOLOGY, CHINESE ACADEMY OF SCIENCESGEOskin cancer, dermis plus epidermis plus hypodermis, the integument, first cervical vertebra, atlas, region of skin, human being, pelt, RNA Sequence Determination, Skn-li, Otf-11, skin neoplasms, Sequence Determination, RNA Sequence, A4, Aging, neoplasm of skin, composed of, Transcription Factor, tumor of zone of skin, TYPE, epidermis, DAGA4, palpebra, neoplasm of skin by site, Biological, AGING BIOL, Analysis, cervical atlas, MAM, SCG3, integumentum commune, Skn-1a, Eyelid, Senescence, Transcription, skin, 身体的皮肤., Analyses, Determination, cell, C1, dermoid system, entire skin, composition, man, SKIN, Sequence Determinations, Sequencing, Biological Aging, skin organ, Skin of body, vertebra 1, zone of skin tumor, RNA Sequence Analyses, Otf11, Fam91a1, cancer of the skin, RNA Sequencing, atlas vertebra, AV220772, skin and subcutaneous tissue, palpebrae, 身体的皮肤, atlas [C I], Sequence Analyses, RNA, Oct-11a, RNA Sequence Determinations, skin zone, integumental organ, Factor, skin tumor, compositionality, Cell, LGMD2C, Determinations, Programs, skin plus hypodermis, skin region, Oct11, BC033609, zone of skin neoplasm (disease), tumor of skin, Skin-1a, BIOL AGING, tegument, Skin, skin benign neoplasm, neoplasm of the skin, Factors, cervical vertebra 1, skin neoplasm, DMDA1, zone of skin neoplasm, content, vertebrate integument, blephara, human, mKIAA0493, Atlases, Epoc-1, tumor of the skin, ageing, portion of skin, vertebrate epidermis, DMDA, integument, RNA Sequence Analysis, SCARMD2, structure, blepharon, atlas (CI), neoplasm of zone of skin, entire integument, eye lid, Hautsystem@de, dermal system, C1 vertebraWrinkling, Skin Wrinkling, Skin Wrinklings, first cervical vertebra, atlas, human being, cervical vertebra 1, Skin Aging, cell, C1, Aging, man, Cell, human, Atlases, vertebra 1, Skin., Solar Aging of Skin, atlas (CI), Photoaging of Skin, cervical atlas, atlas vertebra, Skin, C1 vertebra, atlas [C I]0.00.00.00.002dbgap_ncbi~0patentfamilies~0rfam~0merops~0complex-portal~0uniprot~0wormbaseparasite~0embl-covid19~0reactome~0emdb~0wgs_masters~0ebiweb_resources~0opentargets_genetics~0biomodels_all~0ipd-mhc~0ebiweb_teams~0genome_assembly~0sc-experiments~0taxonomy~1ebiweb_people~0enzymeportal_enzymes~0ipd-nhkir~0cellosaurus~0pdbe~0chebi~0patentproteins~0interpro7~0uniref~0chembl~0pdbekb~0gpcrdb~0hgnc~0sc-genes~0intact~0rhea~0ebiweb_training~0alphafold~0imgt-hla~0patentnucleotides~0ensemblroot~0eva_studies~0non-coding~0europepmc~0identifiers_registry~0pdbechem~0hpa-covid19~0eva-variants-covid19~0biosamples~0gwas_catalog~0biotools~0tls_masters~0mesh~0coding~0sra~0opentargets~0efo~0embl-pathogen~0human_diseases~0geo_datasets~0embl~0treefam~0project~1uniparc~0ols~0dgva~0intenz~0go~0tsa_masters~0biosamples-covid19~0ebiweb_corporate~0omim~0lrg~0earlycause-molecular-sequences~0ipd-kir~0empiar~0rnacentral~0orcid_data_claims~0lineage-covid19~0gpmdb~0metagenomics~0pfam~0varsite~01.1610767593651E-6falseA Single-Cell Transcriptomic Atlas of Human Skin AgingTo obtain the first aging atlas of human skin, we systematically analyzed 35,678 cells of skin sampled from young,middle and old  human eyelid. Systemic effects of aging on different skin cell types were evaluated in terms of cell-type composition, cell-specific molecular programs, transcription factors network. Overall design: Single-cell RNA sequencing for 35K cells of human skin2020-04-292020-03-02GSE1461929606