GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE15nnn/GSE15356/primaryOK2000000GenomicsHomo sapiensExpression profiling by arrayhttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE15356GEOGSE0falseTranscriptional and polysomal profile of poliovirus-infected HUVECsTranslation initiation of eukaryotic mRNAs mostly occurs by the cap-dependent ribosome scanning mechanism. However, certain mRNAs are translated by ribosome assembly at internal ribosome entry sites (IRES), a mechanism that allows the synthesis of certain proteins when cap-dependent translation is inhibited by cellular stress. Whether IRES-mediated translation occurs in stressed human endothelial cells (EC) is unknown. We performed whole genome microarray analysis of polyribosomal mRNA (43,203 sequences) from virus-infected EC to identify IRES-containing mRNAs.2009/03/27GSE15356GSM385527GSM385516170815356Homo sapiens