{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE164nnn/GSE164138/"]},"type":"primary"},"statusCodeValue":200,"statusCode":"OK"}],"scores":null,"additional":{"omics_type":["Other"],"species":["Homo sapiens"],"gds_type":["Other"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE164138"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Sequencing 5-formyluracil in genome DNA at single-base resolution","description":"Albeit with low content, in genome DNA, the 5-formyluracil has been an important modification. The 5-formyluracil was found to be widely distributed amongst living bodies (prokaryotes and mammalian cells). Capable of binding to proteins to prevent the gene expressions, the 5-formyluracil could also induce mismatch in the DNA. In certain cancerous tissues, the content of 5-formyluracil was found to be higher than the normal tissues adjacent to the tumor. Nonetheless, the lack of a higher resolution mapping technique, has been hampering the studies of 5-formyluracil. Hence, we adopted the single-base resolution analysis method to profile 5-formyluracil at the genome scale. We analyzed the distribution of 5-formyluracil in the genome. This technique enabled us to have a better understanding of 5-formyluracil.","dates":{"publication":"2022/12/01"},"accession":"GSE164138","cross_references":{"GSM":["GSM4998043","GSM4998044","GSM4998041","GSM4998042","GSM4998040","GSM4998039"],"GPL":["20795"],"SRA":["SRP300041"],"GSE":["164138"],"taxon":["Homo sapiens"]}}