{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE172nnn/GSE172313/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE172313"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Novel Cellular Patterns and Gene Drivers of Relapse in Adult Acute Myelogenous Leukemia","description":"Through the analysis of 20 paired AML specimens procured before and at relapse from therapy we have identified three cellular relapse patterns: i) shift to immaturity; ii) proportional regrowth, and, iii) shift to monocyte-like cells. We traced AML driver mutations back into early HSC/MPP like cells. We identify high confidence genes that are differentially expressed in matched cell types between AML cells at diagnosis versus relapse. We credentialled a subset of these genes via CRISPR-Cas9 screens in ten AML cell lines. Overall, we identify novel patterns and drivers of AML relapse.","dates":{"publication":"2026/07/24"},"accession":"GSE172313","cross_references":{"GSM":["GSM5252354","GSM5252353","GSM5252352","GSM5252351","GSM5252350","GSM5252359","GSM5252358","GSM5252357","GSM5252356","GSM5252355","GSM5252365","GSM5252364","GSM5252363","GSM5252362","GSM5252361","GSM5252360","GSM5252369","GSM5252368","GSM5252367","GSM5252366","GSM5252376","GSM5252332","GSM5252331","GSM5252375","GSM5252374","GSM5252373","GSM5252372","GSM5252371","GSM5252370","GSM5252339","GSM5252338","GSM5252337","GSM5252336","GSM5252379","GSM5252335","GSM5252334","GSM5252378","GSM5252333","GSM5252377","GSM5252343","GSM5252342","GSM5252341","GSM5252340","GSM5252383","GSM5252382","GSM5252381","GSM5252380","GSM5252349","GSM5252348","GSM5252347","GSM5252346","GSM5252345","GSM5252344"],"GPL":["18573","24676"],"SRA":["SRP315322"],"GSE":["172313"],"taxon":["Homo sapiens"]}}