{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE174nnn/GSE174160/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE174160"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"SFPQ rescues F508del-CFTR expression and function in cystic fibrosis bronchial epithelial cells","description":"Here, we investigated the role of SFPQ in the regulation of expression and function of F508del-CFTR in CF lung epithelial cells. We find that the expression of SFPQ is reduced in F508del-CFTR CF epithelial cells compared to WT-CFTR control cells. Interestingly, the overexpression of SFPQ in CF cells increases the expression as well as rescues the function of F508del­CFTR. Further, comprehensive transcriptome analyses indicate that SFPQ plays a key role in activating the mutant F508del-CFTR by modulating several cellular signaling pathways. This is the first report on the role of SFPQ in the regulation of expression and function of F508del-CFTR in CF lung disease.","dates":{"publication":"2026/04/21"},"accession":"GSE174160","cross_references":{"GSM":["GSM5288125","GSM5288126","GSM5288130","GSM5288127","GSM5288128","GSM5288129"],"GPL":["16791"],"SRA":["SRP319174"],"GSE":["174160"],"taxon":["Homo sapiens"],"PMID":["[34404863]"]}}